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Ablation of Ligament of Marshall Attenuates Atrial Vulnerability to Fibrillation Induced by Inferior Left Atrial Fat Pad Stimulation in Dogs
Liu, Xingpeng1; Yan, Qian1; Li, Hui1; Tian, Ying1; Su, Jing2; Tang, Ribo1; Lu, Chunshan1; Dong, Jianzeng1; Ma, Changsheng1
关键词atrial fibrillation ligament of Marshall catheter ablation atrial fat pad autonomic nervous system
刊名JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
2010-09-01
DOI10.1111/j.1540-8167.2010.01746.x
21期:9页:1024-1030
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
资助者National Science Foundation Council of China ; National Science Foundation Council of China
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]CATHETER ABLATION ; NEURAL-NETWORK ; PULMONARY VEIN ; MODEL ; TACHYCARDIA ; PLEXI
英文摘要

Objective: To investigate the impact of LOM ablation on atrial vulnerability to AF induced by inferior left atrial fat pad (ILAFP) stimulation in dogs.

Methods: AF inducibility and atrial effective refractory period (ERP) were elevated before and after LOM ablation in 8 of 14 dogs (the ablation group). Same protocol but without LOM ablation was conducted in the remaining 6 dogs (the control group). The activation patterns of LOM and left pulmonary veins (LPVs) during sustained AF were analyzed. The distribution of epicardial cholinergic nerve fibers between LOM and ILAFP was investigated in the control group.

Results: Ablation of LOM significantly attenuated AF inducibility (87.5% vs 33.3%, P < 0.001) and prolonged ERPs of the structures in contiguity with LOM (P < 0.05) in the ablation group. In contrast, there was no significant change in ERPs and AF inducibility in the control group. During sustained AF, fractionated atrial electrograms were more common in the LOM area than the LPVs (84% vs 18% of the analyzed episodes, P < 0.001). In 46.7% of the episodes with identifiable LOM spikes, atrial potentials, and LOM spikes were related in 2:1 or 3:2 pattern during the intermittent organized activity. Acetylcholinesterase staining revealed a close cholinergic nerved relationship between LOM and ILAFP.

Conclusions: LOM plays a critical role in maintaining AF induced by stimulation of ILAFP. Ablation of LOM can markedly attenuate AF inducibility in this model. (J Cardiovasc Electrophysiol, Vol. 21, pp. 1024-1030, September 2010).

语种英语
所属项目编号30500202
资助者National Science Foundation Council of China ; National Science Foundation Council of China
WOS记录号WOS:000281556000011
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60446
专题基础医学院_病理学系
作者单位1.Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Ctr Atrial Fibrillat, Beijing 100029, Peoples R China
2.Beijing Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
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GB/T 7714
Liu, Xingpeng,Yan, Qian,Li, Hui,et al. Ablation of Ligament of Marshall Attenuates Atrial Vulnerability to Fibrillation Induced by Inferior Left Atrial Fat Pad Stimulation in Dogs[J]. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY,2010,21(9):1024-1030.
APA Liu, Xingpeng.,Yan, Qian.,Li, Hui.,Tian, Ying.,Su, Jing.,...&Ma, Changsheng.(2010).Ablation of Ligament of Marshall Attenuates Atrial Vulnerability to Fibrillation Induced by Inferior Left Atrial Fat Pad Stimulation in Dogs.JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY,21(9),1024-1030.
MLA Liu, Xingpeng,et al."Ablation of Ligament of Marshall Attenuates Atrial Vulnerability to Fibrillation Induced by Inferior Left Atrial Fat Pad Stimulation in Dogs".JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 21.9(2010):1024-1030.
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