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Use of first- and second-generation antipsychotic medications in older patients with schizophrenia in Asia (2001-2009)
Xiang, Yu-Tao1,2; Kreyenbuhl, Julie3,4; Dickerson, Faith B.5; Ungvari, Gabor S.6; Wang, Chuan-Yue2; Si, Tian-Mei7,8; Lee, Edwin H.1; He, Yan-Ling9; Chiu, Helen F.1; Yang, Shu-Yu10; Chong, Mian-Yoon11,12; Tan, Chay-Hoon13; Kua, Ee-Heok14; Fujii, Senta15; Sim, Kang16; Yong, Michael K.16; Trivedi, Jitendra K.17; Chung, Eun-Kee18; Udomratn, Pichet19; Chee, Kok-Yoon20; Sartorius, Norman21; Shinfuku, Naotaka22
关键词Asia older patients prescription patterns schizophrenia
刊名AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
2012-12-01
DOI10.1177/0004867412453625
46期:12页:1159-1164
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]ELDERLY-PATIENTS ; EAST-ASIA ; OLANZAPINE ; EFFICACY ; SAFETY ; POLYPHARMACY ; RISPERIDONE
英文摘要

Objective: This study examined the prescribing patterns of several first-(FGAs) and second-generation antipsychotic (SGAs) medications administered to older Asian patients with schizophrenia during the period between 2001 and 2009.

Method: Information on hospitalized patients with schizophrenia aged 65 or older was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) study (2001-2009). There were no older patients in Thailand, therefore data on 467 patients in eight Asian countries and territories including China, Hong Kong SAR, India, Japan, Korea, Malaysia, Singapore, and Taiwan were analysed. Cross-sectional socio-demographic data, clinical characteristics and antipsychotic prescriptions were assessed using a standardized protocol and data collection procedure.

Results: Of the 467 patients, 192 patients (41.1%) received FGAs only, 166 (35.5%) received SGAs only and 109 (23.3%) received a combination of FGAs and SGAs. Of the FGAs, haloperidol was the most commonly used (31.3%; mean 9.4 +/- 6.7 mg/day), followed by chlorpromazine (15.4%; mean 126.4 +/- 156.4 mg/day) and sulpiride (6.6%; mean 375.0 +/- 287.0 mg/day). Of the SGAs, risperidone was the most commonly used (31.5%; mean 4.5 +/- 2.7 mg/day), followed by olanzapine (13.1%; mean 13.6 +/- 6.5 mg/day), quetiapine (7.3%; mean 325.0 +/- 237.3 mg/day) and aripiprazole (1.9%; mean 17.6 +/- 7.7 mg/day).

Conclusions: FGAs and higher doses of certain SGAs (risperidone, olanzapine and quetiapine) were still commonly dispensed to older Asian patients with schizophrenia. Considering older patients′ reduced tolerability of potentially severe side effects associated with FGAs and higher doses of certain SGAs, continuing education and training addressing the rational use of antipsychotics in this population is clearly needed.

语种英语
WOS记录号WOS:000311884800007
项目编号81171270 ; 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
资助机构National Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission ; Chinese University of Hong Kong ; Institute of Mental Health research in Singapore ; Bureau of National Health Insurance in Taiwan ; Chang Gung Memorial Hospital ; Taipei City Government, Taiwan
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60447
专题北京大学精神卫生研究所
作者单位1.Chang Gung Univ, Sch Med, Gueishan, Taiwan
2.Hyogo Inst Traumat Stress HITS, Kobe, Hyogo, Japan
3.Inst Mental Hlth, Buangkok View, Singapore
4.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
5.Natl Seoul Hosp, Seoul, South Korea
6.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland
7.Seinan Gakuin Univ, Sch Human Sci, Fukuoka, Japan
8.Sheppard Pratt, Stanley Res Program, Baltimore, MD USA
9.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
10.Taipei City Hosp, Taipei, Taiwan
11.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
12.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
13.Univ Maryland, Sch Med, Dept Psychiat, Div Res Serv, Baltimore, MD 21201 USA
14.Mental Illness Res Educ & Clin Ctr MIRECC, Vet Adm Capitol Healthcare Network VISN 5, Baltimore, MD USA
15.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
16.Peking Univ, Key Lab Mental Hlth, Minist Mental Hlth, Inst Mental Hlth, Beijing 100871, Peoples R China
17.Peking Univ, Dept Psychopharmacol, Inst Mental Hlth, Beijing 100871, Peoples R China
18.Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Gueishan, Taiwan
19.Natl Univ Singapore, Dept Pharmacol, Singapore 117548, Singapore
20.Natl Univ Singapore, Dept Psychol Med, Singapore 117548, Singapore
21.Prince Songkla Univ, Fac Med, Dept Psychiat, Hat Yai, Thailand
22.Kuala Lumpur Hosp, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia
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GB/T 7714
Xiang, Yu-Tao,Kreyenbuhl, Julie,Dickerson, Faith B.,et al. Use of first- and second-generation antipsychotic medications in older patients with schizophrenia in Asia (2001-2009)[J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,2012,46(12):1159-1164.
APA Xiang, Yu-Tao.,Kreyenbuhl, Julie.,Dickerson, Faith B..,Ungvari, Gabor S..,Wang, Chuan-Yue.,...&Shinfuku, Naotaka.(2012).Use of first- and second-generation antipsychotic medications in older patients with schizophrenia in Asia (2001-2009).AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,46(12),1159-1164.
MLA Xiang, Yu-Tao,et al."Use of first- and second-generation antipsychotic medications in older patients with schizophrenia in Asia (2001-2009)".AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY 46.12(2012):1159-1164.
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