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学科主题: 临床医学
题名:
Diabetic Patients Could Do As Well as Non-Diabetic Patients without Inflammation on Peritoneal Dialysis
作者: Xu, Rong1; Han, QingFeng2; Zhu, TongYing3; Ren, Yeping4; Chen, JiangHua5; Zhao, HuiPing6; Chen, MengHua7; Dong, Jie1; Wang, Yue2; Hao, ChuanMing3; Zhang, Rui4; Zhang, Xiaohui5; Wang, Mei6; Tian, Na7; Wang, HaiYan1
刊名: PLOS ONE
发表日期: 2013-11-18
DOI: 10.1371/journal.pone.0080486
卷: 8, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: RESIDUAL RENAL-FUNCTION ; C-REACTIVE PROTEIN ; GLYCATION END-PRODUCTS ; CORONARY-HEART-DISEASE ; LOW-GRADE INFLAMMATION ; ENDOTHELIAL DYSFUNCTION ; TECHNIQUE FAILURE ; BLOOD-PRESSURE ; RISK-FACTORS ; MORTALITY
英文摘要:

Background: Diabetic patients on peritoneal dialysis (PD) have lower survival and are more likely complicated with inflammation than their non-diabetic counterparts. Here, we explored the interaction effects between diabetes and inflammation on the survival of PD patients.

Methods: Overall, 2,264 incident patients were enrolled from a retrospective cohort study in China. Patients were grouped according to the baseline levels of high-sensitive C-reactive protein (hsCRP, <= 3 mg/L or >3 mg/L) or serum albumin (SA, >= 38 g/L or <38 g/L). Then, several multivariable adjusted stratified Cox regsion models were constructed for these groups to explore the predicted role of diabetes on all-cause or cardiovascular death under inflammatory or non-inflammatory conditions.

Results: Diabetics on PD were more likely to have inflammation than non-diabetics on PD, and they presented with elevated hsCRP (52.7% vs. 47.3%, P = 0.03) or decreased SA (77.9% vs. 62.7%, P < 0.001) levels. After stratification by size of center and controlling for confounding factors, diabetes was found to predict all-cause death in patients with hsCRP >3 mg/L or SA <38 g/L but not in patients with hsCRP <= 3 mg/L or SA >= 38 g/L. Similarly, the presence of diabetes was an indication of cardiovascular death in patients with hsCRP >3 mg/L or SA <38 g/L. However, if further adjusted by baseline cardiovascular disease, the predicted role of diabetes on death related to cardiovascular disease in patients with SA <38 g/L disappeared.

Conclusion: Diabetic patients could do as well as non-diabetic patients without inflammation on peritoneal dialysis. Active strategies should be implemented to improve inflammation status in diabetic patients on PD.

语种: 英语
项目资助者: Baxer Clinical Research Award of Baxter Corp ; China and the ISN Research Award of ISN GO RP Committee
WOS记录号: WOS:000327308500144
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60448
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Ningxia Med Univ, Gen Hosp, Dept Nephrol, Ningxia, Peoples R China
2.Peking Univ, Hosp 1, Key Lab Renal Dis, Renal Div,Dept Med,Inst Nephrol,Minist Hlth,Minis, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 3, Dept Nephrol, Beijing 100871, Peoples R China
4.Fudan Univ, Huashan Hosp, Dept Nephrol, Shanghai 200433, Peoples R China
5.Harbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Heilongjiang, Peoples R China
6.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Kidney Dis Ctr, Hangzhou 310003, Zhejiang, Peoples R China
7.Peking Univ, Dept Nephrol, Peoples Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Xu, Rong,Han, QingFeng,Zhu, TongYing,et al. Diabetic Patients Could Do As Well as Non-Diabetic Patients without Inflammation on Peritoneal Dialysis[J]. PLOS ONE,2013,8(11).
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