|Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris|
|Ma, Li1; Xiang, Lei-Hong1; Yu, Bo2; Yin, Rui3; Chen, Lei4; Wu, Yan5; Tan, Zhi-Jian6; Liu, Yong-Bin7; Tian, Hong-Qing8; Li, Hui-Zhong9; Lin, Tong10; Wang, Xiu-Li11; Li, Yuan-Hong12; Wang, Wei-Zheng13; Yang, Hui-Lan14; Lai, Wei15|
|关键词||Acne vutgaris Severity Aminotevutinic acid Photodynamic therapy|
|刊名||PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY|
|WOS标题词||Science & Technology|
|关键词[WOS]||DELTA-AMINOLEVULINIC-ACID ; PROTOPORPHYRIN-IX ; SEBACEOUS GLANDS ; LIGHT ; BASICS ; TRIAL ; BLUE|
Objectives: To investigate the efficacy and safety of low-concentration 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of different severity of acne vulgaris and optimize the treatment regimen.
Methods: A self-controlled multicenter clinical trial was carried out in 15 centers throughout China. A total of 397 acne patients of grade II-IV received 3- or 4-session PDT treatment. 5% ALA gel was applied topically to acne lesions for 1 h incubation. The lesions were irradiated by a LED light of 633 nm at dose levels of 96-120 J/cm(2). Clinical assessment was conducted before and after every treatment up to 8 weeks.
Results: The effective rate overall and of grade II, III and IV are 82.1%, 71.6%, 79.6% and 88.2%, respectively. The effective rate rises significantly proportionally to the severity of acne (P < 0.01). No significant differences are found in the efficacy between patients received 3-session and 4-session PDT treatments (P > 0.05). The count of inflammatory and noninflammatory acne lesions gradually decrease after each treatment (P < 0.01) and during the 8-week follow up (P < 0.01 or P < 0.05). Maximum efficacy is obtained at 8 weeks after the treatment completion.
Conclusions: A low-dose topical ALA-PDT regimen using 5% ALA, 1 h incubation and red light source of 3 treatment sessions is suggested as optimal scheme for the treatment of different severity of acne vulgaris in Chinese patients. Superior efficacy is found in severe cystic acne of grade IV with mild side effects. (C) 2013 Elsevier B.V. All rights reserved.
|作者单位||1.Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200040, Peoples R China|
2.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Peoples R China
3.Third Mil Med Univ, Southwest Hosp, Chongqing 400038, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai 200025, Peoples R China
5.Peking Univ, Hosp 1, Beijing 100034, Peoples R China
6.Wuhan Union Hosp, Wuhan 430022, Peoples R China
7.Shenyang Seventh Peoples Hosp, Shenyang 110003, Peoples R China
8.Shandong Prov Hosp Skin Dis, Jinan 250022, Peoples R China
9.Guangdong Prov Dermatol Hosp, Guangzhou 510095, Guangdong, Peoples R China
10.Chinese Acad Med Sci, Inst Dermatol, Nanjing 210042, Jiangsu, Peoples R China
11.Shanghai Skin Dis & STD Hosp, Shanghai 200050, Peoples R China
12.China Med Univ, Hosp 1, Shenyang 110001, Peoples R China
13.Wuhan 1 Hosp, Wuhan 430022, Peoples R China
14.Guangzhou Mil Area Command, Guangzhou Gen Hosp, Guangzhou 510010, Guangdong, Peoples R China
15.Zhongshan Univ, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China
|Ma, Li,Xiang, Lei-Hong,Yu, Bo,et al. Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,2013,10(4):583-590.|
|APA||Ma, Li.,Xiang, Lei-Hong.,Yu, Bo.,Yin, Rui.,Chen, Lei.,...&Lai, Wei.(2013).Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris.PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,10(4),583-590.|
|MLA||Ma, Li,et al."Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris".PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY 10.4(2013):583-590.|