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学科主题: 临床医学
题名:
Early liraglutide treatment is better in glucose control, beta-cell function improvement and mass preservation in db/db mice
作者: Shao, Yimin1; Yuan, Geheng1; Feng, Yan2; Zhang, Junqing1; Guo, Xiaohui1
关键词: T2DM ; beta-Cell ; Liraglutide ; Early intervention
刊名: PEPTIDES
发表日期: 2014-02-01
DOI: 10.1016/j.peptides.2013.11.011
卷: 52, 页:134-142
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: GLUCAGON-LIKE PEPTIDE-1 ; DEPENDENT DIABETIC-PATIENTS ; GLP-1 7-36 AMIDE ; INSULIN-SECRETION ; EXPRESSION ; RATS ; HYPERGLYCEMIA ; NORMALIZATION ; DEGRADATION ; MONOTHERAPY
英文摘要:

Glucagon-like peptide-1 (GLP-1) has been proved to have effects of anti-hyperglycemia and beta-cell preservation. However, it is still unclear whether there are differences between early and late GLP-1 intervention in type 2 diabetes mellitus (T2DM). We divided the mice into 5 groups: early treated group (n = 7, 8-week old, fasting glucose > 10 mmol/l), late treated group (n = 7, 10-week old, fasting glucose > 20 mmol/l), early control group (n = 7), late control group (n = 7) and wild type group (n = 7). Treated group was injected with liraglutide (a GLP-1 analog) 300 mu g/kg bid for 4 weeks, while control group was given saline at the same time. The results showed that compared with control group, food intake and body weight gain were reduced in both early and late treated group (p < 0.05), and there was no significance between the two treated groups. Early liraglutide intervention showed better improvements in glucose control, acute insulin response to glucose (AIRg) and disposition index (before vs. after treatment, AIRg 1.01 +/- 0.53 vs. 2.98 +/- 0.63, disposition index 10.81 +/- 0.89 vs. 27.4 +/- 2.15) than late intervention (AIRg 0.99 +/- 0.02 vs. 1.41 +/- 0.32, disposition index 3.47 +/- 0.38 vs. 6.43 +/- 1.62, p = 0.001). The histopathology of the pancreas showed the estimated beta-cell mass (BCM) was increased more in early treated group than that in late one (0.03 vs. 0.01 g). Expressions of the proliferation related genes PDX-1, MafA and GLP-1 receptor (GLP-1R) in early treated group were 1.81, 2.57 and 1.59 times as much as that in late treated group. In conclusion, early liraglutide intervention was better in glucose control, beta-cell function improvement and beta-cell mass preservation. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
项目资助者: beta-cell academic project of China International Medical Foundation
WOS记录号: WOS:000333275400020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60460
Appears in Collections:北京大学第一临床医学院_内分泌内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China
2.Huguosi Hosp Tradit Chinese Med, Beijing, Peoples R China

Recommended Citation:
Shao, Yimin,Yuan, Geheng,Feng, Yan,et al. Early liraglutide treatment is better in glucose control, beta-cell function improvement and mass preservation in db/db mice[J]. PEPTIDES,2014,52:134-142.
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