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学科主题临床医学
Early liraglutide treatment is better in glucose control, beta-cell function improvement and mass preservation in db/db mice
Shao, Yimin1; Yuan, Geheng1; Feng, Yan2; Zhang, Junqing1; Guo, Xiaohui1
关键词T2DM beta-Cell Liraglutide Early intervention
刊名PEPTIDES
2014-02-01
DOI10.1016/j.peptides.2013.11.011
52页:134-142
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]GLUCAGON-LIKE PEPTIDE-1 ; DEPENDENT DIABETIC-PATIENTS ; GLP-1 7-36 AMIDE ; INSULIN-SECRETION ; EXPRESSION ; RATS ; HYPERGLYCEMIA ; NORMALIZATION ; DEGRADATION ; MONOTHERAPY
英文摘要

Glucagon-like peptide-1 (GLP-1) has been proved to have effects of anti-hyperglycemia and beta-cell preservation. However, it is still unclear whether there are differences between early and late GLP-1 intervention in type 2 diabetes mellitus (T2DM). We divided the mice into 5 groups: early treated group (n = 7, 8-week old, fasting glucose > 10 mmol/l), late treated group (n = 7, 10-week old, fasting glucose > 20 mmol/l), early control group (n = 7), late control group (n = 7) and wild type group (n = 7). Treated group was injected with liraglutide (a GLP-1 analog) 300 mu g/kg bid for 4 weeks, while control group was given saline at the same time. The results showed that compared with control group, food intake and body weight gain were reduced in both early and late treated group (p < 0.05), and there was no significance between the two treated groups. Early liraglutide intervention showed better improvements in glucose control, acute insulin response to glucose (AIRg) and disposition index (before vs. after treatment, AIRg 1.01 +/- 0.53 vs. 2.98 +/- 0.63, disposition index 10.81 +/- 0.89 vs. 27.4 +/- 2.15) than late intervention (AIRg 0.99 +/- 0.02 vs. 1.41 +/- 0.32, disposition index 3.47 +/- 0.38 vs. 6.43 +/- 1.62, p = 0.001). The histopathology of the pancreas showed the estimated beta-cell mass (BCM) was increased more in early treated group than that in late one (0.03 vs. 0.01 g). Expressions of the proliferation related genes PDX-1, MafA and GLP-1 receptor (GLP-1R) in early treated group were 1.81, 2.57 and 1.59 times as much as that in late treated group. In conclusion, early liraglutide intervention was better in glucose control, beta-cell function improvement and beta-cell mass preservation. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000333275400020
资助机构beta-cell academic project of China International Medical Foundation
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60460
专题北京大学第一临床医学院_内分泌内科
作者单位1.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China
2.Huguosi Hosp Tradit Chinese Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Shao, Yimin,Yuan, Geheng,Feng, Yan,et al. Early liraglutide treatment is better in glucose control, beta-cell function improvement and mass preservation in db/db mice[J]. PEPTIDES,2014,52:134-142.
APA Shao, Yimin,Yuan, Geheng,Feng, Yan,Zhang, Junqing,&Guo, Xiaohui.(2014).Early liraglutide treatment is better in glucose control, beta-cell function improvement and mass preservation in db/db mice.PEPTIDES,52,134-142.
MLA Shao, Yimin,et al."Early liraglutide treatment is better in glucose control, beta-cell function improvement and mass preservation in db/db mice".PEPTIDES 52(2014):134-142.
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