IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Mesenchymal Chondrosarcoma of Bone and Soft Tissue: A Systematic Review of 107 Patients in the Past 20 Years
Xu, Jie; Li, Dasen; Xie, Lu; Tang, Shun; Guo, Wei
刊名PLOS ONE
2015-04-07
DOI10.1371/journal.pone.0122216
10期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]OF-THE-LITERATURE ; CONDITIONAL SURVIVAL ; UNUSUAL SITE ; RARE TUMOR ; ORBIT ; CELL ; DIFFERENTIATION ; OSTEOSARCOMA ; MIMICKING ; DIAGNOSIS
英文摘要

Background

Mesenchymal chondrosarcoma(MCS) is a rare high-grade variant of chondrosarcoma. Consensus has not been reached on its optimal management. Resection with wide margins is usually recommended, but the effect of margins has been demonstrated by little positive evidence. Moreover, the effectiveness of adjuvant chemo- and/or radiotherapy remains controversial.

Objectives

To describe the clinical characteristics and outcomes of MCS of bone and soft tissue, to assess the efficacies of surgery, chemotherapy and radiation, and finally to deliver a more appropriate therapy.

Materials and Methods

We reviewed EMBASE-, MEDLINE-, Cochrane-, Ovid- and PubMed-based to find out all cases of MCS of bone and soft tissue described between April 1994 and April 2014. Description of treatment and regular follow-up was required for each study. Language was restricted to English and Chinese. Issues of age, gender, location, metastasis, and treatment were all evaluated for each case. Kaplan-Meier Method and Cox Proportional Hazard Regression Model were used in the survival analysis.

Results

From the 630 identified publications, 18 meeting the inclusion criteria were selected, involving a total of 107 patients. Based on these data, the 5-, 10- and 20-year overall survival are 55.0%, 43.5% and 15.7% respectively. The 5-, 10-, 20-year event-free survival rates are 45.0%, 27.2% and 8.1%, respectively. Treatment without surgery is associated with poorer overall survival and event-free survival. Negative surgical margins could significantly bring down the local-recurrence rate and are associated with a higher event-free survival rate. Chemotherapy regime based on anthracyclines does not benefit the overall survival. The addition of radiation therapy is not significantly associated with the overall or event-free survival. However, we recommend radiation as the salvage therapy for patients with positive margin so as to achieve better local control.

Conclusions

This review shows that surgery is essential in the management of MCS of bone and soft tissue. Appropriate adjuvant therapy may reduce local recurrence, but cannot benefit the overall survival.

语种英语
WOS记录号WOS:000352477800108
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60462
Collection北京大学第二临床医学院
作者单位Peking Univ, Peoples Hosp, Musculoskeletal Tumour Ctr, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Xu, Jie,Li, Dasen,Xie, Lu,et al. Mesenchymal Chondrosarcoma of Bone and Soft Tissue: A Systematic Review of 107 Patients in the Past 20 Years[J]. PLOS ONE,2015,10(4).
APA Xu, Jie,Li, Dasen,Xie, Lu,Tang, Shun,&Guo, Wei.(2015).Mesenchymal Chondrosarcoma of Bone and Soft Tissue: A Systematic Review of 107 Patients in the Past 20 Years.PLOS ONE,10(4).
MLA Xu, Jie,et al."Mesenchymal Chondrosarcoma of Bone and Soft Tissue: A Systematic Review of 107 Patients in the Past 20 Years".PLOS ONE 10.4(2015).
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