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学科主题: 基础医学
题名:
Correlation of hepatitis B virus (HBV) genotypes and mutations in basal core promoter/precore with clinical features of chronic HBV infection
作者: Du, Heng; Li, Tong; Zhang, Hua-Yuan; He, Zhong-Ping; Dong, Qing-Ming; Duan, Xue-Zhang; Zhuang, Hui
关键词: chronic HBV infection ; genotype ; hepatitis B virus (HBV) ; hepatitis e antigen (HBeAg) ; mutation
刊名: LIVER INTERNATIONAL
发表日期: 2007-03-01
DOI: 10.1111/j.1478-3231.2006.01400.x
卷: 27, 期:2, 页:240-246
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; PHYLOGENETIC RELATEDNESS ; PRECORE REGION ; UNITED-STATES ; BLOOD-DONORS ; CARRIERS ; CHINA ; REPLICATION ; VARIANTS ; SUBTYPES
英文摘要:

Background/Aims: To investigate the correlation of hepatitis B virus (HBV) genotypes and basal core promoter (BCP) and precore (PC) mutations in patients with chronic hepatitis B. Methods: HBV genotyping, nucleotide mutation, serum HBV DNA level and serological markers were analyzed in 121 patients with chronic HBV infection using INNO-LiPA HBV genotyping, polymerase chain reaction (PCR) product-based sequencing, fluorescence quantitative PCR and enzyme-linked immunosorbent assays respectively. Results: Forty (33.0%), 77 (63.6%), two (1.7%) and two (1.7%) patients had genotypes B, C, B/C and D infections respectively. Significant differences were found in serum HBV DNA levels (log(10) copies/ml: 6.18 vs. 5.61, P=0.042) and mutations at nucleotide (nt) 1762/1764 (71.4% vs. 42.5%, P=0.002) between genotypes C- and B-infected patients. There were significant differences in the mean age, serum biochemical parameter levels and mutation rates in BCP/PC among hepatitis e antigen (HBeAg)-positive and -negative chronic hepatitis B (CHB) and liver cirrhosis (LC) groups. Conclusion: Genotypes C and B are predominant in China, and the frequent nt 1762/1764 mutation, which occurs commonly in HBeAg-negative CHB, especially in genotype C patients, may be associated with the progress of chronic HBV infection.

语种: 英语
WOS记录号: WOS:000244278200012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60463
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
2.Natl Inst Control Pharmaceut & Biol Prod, Beijing, Peoples R China

Recommended Citation:
Du, Heng,Li, Tong,Zhang, Hua-Yuan,et al. Correlation of hepatitis B virus (HBV) genotypes and mutations in basal core promoter/precore with clinical features of chronic HBV infection[J]. LIVER INTERNATIONAL,2007,27(2):240-246.
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