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学科主题临床医学
Myocardial Injury after Surgery Is a Risk Factor for Weaning Failure from Mechanical Ventilation in Critical Patients Undergoing Major Abdominal Surgery
Li, Shu1; An, You-zhong1; Ren, Jing-yi2; Zhu, Feng-xue1; Chen, Hong2
刊名PLOS ONE
2014-11-19
DOI10.1371/journal.pone.0113410
9期:11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]NONINVASIVE VENTILATION ; NONCARDIAC SURGERY ; CARDIAC-SURGERY ; METAANALYSIS ; OUTCOMES ; CARE
英文摘要

Background: Myocardial injury after noncardiac surgery (MINS) is a newly proposed concept that is common among adults undergoing noncardiac surgery and associated with substantial mortality. We analyzed whether MINS was a risk factor for weaning failure in critical patients who underwent major abdominal surgery.

Methods: This retrospective study was conducted in the Department of Critical Care Medicine of Peking University People′s Hospital. The subjects were all critically ill patients who underwent major abdominal surgery between January 2011 and December 2013. Clinical and laboratory parameters during the perioperative period were investigated. Backward stepwise regression analysis was performed to evaluate MINS relative to the rate of weaning failure. Age, hypertension, chronic renal disease, left ventricular ejection fraction before surgery, Acute Physiologic and Chronic Health Evaluation II score, pleural effusion, pneumonia, acute kidney injury, duration of mechanical ventilation before weaning and the level of albumin after surgery were treated as independent variables.

Results: This study included 381 patients, of whom 274 were successfully weaned. MINS was observed in 42.0% of the patients. The MINS incidence was significantly higher in patients who failed to be weaned compared to patients who were successfully weaned (56.1% versus 36.5%; P < 0.001). Independent predictive factors of weaning failure were MINS, age, lower left ventricular ejection fraction before surgery and lower serum albumin level after surgery. The MINS odds ratio was 4.098 (95% confidence interval, 1.07 to 15.6; P = 0.04). The patients who were successfully weaned had shorter hospital stay lengths and a higher survival rate than those who failed to be weaned.

Conclusion: MINS is a risk factor for weaning failure from mechanical ventilation in critical patients who have undergone major abdominal surgery, independent of age, lower left ventricular ejection fraction before surgery and lower serum albumin levels after surgery.

语种英语
WOS记录号WOS:000345533200114
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60470
专题北京大学第二临床医学院_重症医学科
北京大学第二临床医学院_心血管内科
作者单位1.Peking Univ, Peoples Hosp, Dept Crit Care Med, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Shu,An, You-zhong,Ren, Jing-yi,et al. Myocardial Injury after Surgery Is a Risk Factor for Weaning Failure from Mechanical Ventilation in Critical Patients Undergoing Major Abdominal Surgery[J]. PLOS ONE,2014,9(11).
APA Li, Shu,An, You-zhong,Ren, Jing-yi,Zhu, Feng-xue,&Chen, Hong.(2014).Myocardial Injury after Surgery Is a Risk Factor for Weaning Failure from Mechanical Ventilation in Critical Patients Undergoing Major Abdominal Surgery.PLOS ONE,9(11).
MLA Li, Shu,et al."Myocardial Injury after Surgery Is a Risk Factor for Weaning Failure from Mechanical Ventilation in Critical Patients Undergoing Major Abdominal Surgery".PLOS ONE 9.11(2014).
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