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学科主题药学
MnTM-4-PyP Modulates Endogenous Antioxidant Responses and Protects Primary Cortical Neurons against Oxidative Stress
Cheng, Kuo-Yuan; Guo, Fei; Lu, Jia-Qi; Cao, Yuan-Zhao; Wang, Tian-Chang; Yang, Qi; Xia, Qing
关键词Endogenous antioxidant response Manganese porphyrin MnTM-4-PyP Sirt3 Superoxide dismutase
刊名CNS Neuroscience & Therapeutics
2015-05-01
DOI10.1111/cns.12373
21期:5页:435-445
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; Beijing Nova Program ; National Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Nova Program ; National Basic Research Program of China
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]MANGANESE SUPEROXIDE-DISMUTASE ; WATER-SOLUBLE PORPHYRINS ; ENDOPLASMIC-RETICULUM DYSFUNCTION ; PARKINSONS-DISEASE ; NEURODEGENERATIVE DISEASES ; TRANSCRIPTIONAL REGULATION ; CHEMICAL-PROPERTIES ; HYDROGEN-PEROXIDE ; REACTIVE OXYGEN ; IN-VITRO
英文摘要

AimsOxidative stress is a direct cause of injury in various neural diseases. Manganese porphyrins (MnPs), a large category of superoxide dismutase (SOD) mimics, shown universally to have effects in numerous neural disease models in vivo. Given their complex intracellular redox activities, detailed mechanisms underlying the biomedical efficacies are not fully elucidated. This study sought to investigate the regulation of endogenous antioxidant systems by a MnP (MnTM-4-PyP) and its role in the protection against neural oxidative stress.

MethodsPrimary cortical neurons were treated with MnTM-4-PyP prior to hydrogen peroxide-induced oxidative stress.

ResultsMnTM-4-PyP increased cell viability, reduced intracellular level of reactive oxygen species, inhibited mitochondrial apoptotic pathway, and ameliorated endoplasmic reticulum function. The protein levels and activities of endogenous SODs were elevated, but not those of catalase. SOD2 transcription was promoted in a transcription factor-specific manner. Additionally, we found FOXO3A and Sirt3 levels also increased. These effects were not observed with MnTM-4-PyP alone.

ConclusionInduction of various levels of endogenous antioxidant responses by MnTM-4-PyP has indispensable functions in its protection for cortical neurons against hydrogen peroxide-induced oxidative stress.

语种英语
所属项目编号21371013 ; 2010010 ; 2010CB12300
资助者National Natural Science Foundation of China ; Beijing Nova Program ; National Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Nova Program ; National Basic Research Program of China
WOS记录号WOS:000353232200006
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60472
专题北京大学药学院_化学生物学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Cheng, Kuo-Yuan,Guo, Fei,Lu, Jia-Qi,et al. MnTM-4-PyP Modulates Endogenous Antioxidant Responses and Protects Primary Cortical Neurons against Oxidative Stress[J]. CNS Neuroscience & Therapeutics,2015,21(5):435-445.
APA Cheng, Kuo-Yuan.,Guo, Fei.,Lu, Jia-Qi.,Cao, Yuan-Zhao.,Wang, Tian-Chang.,...&Xia, Qing.(2015).MnTM-4-PyP Modulates Endogenous Antioxidant Responses and Protects Primary Cortical Neurons against Oxidative Stress.CNS Neuroscience & Therapeutics,21(5),435-445.
MLA Cheng, Kuo-Yuan,et al."MnTM-4-PyP Modulates Endogenous Antioxidant Responses and Protects Primary Cortical Neurons against Oxidative Stress".CNS Neuroscience & Therapeutics 21.5(2015):435-445.
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