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Metabolic heterogeneity of follicular amino acids in polycystic ovary syndrome is affected by obesity and related to pregnancy outcome
Zhang, Chun-mei1,2,3; Zhao, Yue1,2,3; Li, Rong1,2,3; Yu, Yang1,2; Yan, Li-ying1,2; Li, Li2,3; Liu, Na-na1,3; Liu, Ping1,2; Qiao, Jie1,2,3
关键词PCOS Amino acid Obesity Follicular fluid
刊名BMC PREGNANCY AND CHILDBIRTH
2014-01-10
DOI10.1186/1471-2393-14-11
14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]D-ASPARTIC ACID ; DEVELOPMENTAL COMPETENCE ; INSULIN-RESISTANCE ; OOCYTE QUALITY ; GLYCINE ; CELLS ; WOMEN ; CYTOKINES ; FLUID ; EXPRESSION
英文摘要

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder frequently accompanied by obesity and by insulin resistance, and patients with this syndrome suffer from infertility and poor pregnancy outcome. Disturbances in plasma amino acid (AA) metabolism have been implicated in women with PCOS. However, direct evidence on follicular AA metabolic profiles in PCOS patients and their relationship with pregnancy outcome is sparse.

Methods: We conducted a prospective study in 63 PCOS patients and 48 controls in the Division of Reproductive Center, Peking University Third Hospital. Follicular AA levels were measured by the liquid chromatography-tandem mass spectrometric method, and the results were analyzed based on different grouping criteria.

Results: The levels of aromatic amino acid (AAA) increased in PCOS patients independent of obesity (P < 0.05), whereas the levels of branched-chain amino acid (BCAA), glutamic acid, phenylalanine, alanine, and arginine increased with body mass index irrespective of the PCOS status (all P < 0.05). In addition, compared with non insulin resistant-PCOS patients and controls, insulin resistant-PCOS group had higher levels of leucine, valine and glutamic acid (all P < 0.05). In PCOS group, aspartic acid and serine levels were elevated in pregnant patients compared with the non-pregnant subjects (both P < 0.05). Moreover, the levels of BCAA and valine were higher in the non-pregnant group than in the pregnant group (both P < 0.05). The pregnancy rate (45.00%) of subjects with elevated BCAA level was significantly lower than that (66.67%) in control subjects (P = 0.036) at a BCAA cutoff value of 239.10 mu M, while the abortion rate was much higher (33.33% versus 2.78%, P = 0.004).

Conclusions: Both PCOS and obesity were accompanied by follicular AA metabolic disturbances, with obesity exerting a more pronounced effect on AA metabolic profiles. The disruptions in specific AAs in the follicular fluid might account for the inferior pregnancy outcome in obese patients and increased risk of abortion in PCOS patients.

语种英语
WOS记录号WOS:000331215300001
项目编号81170538 ; 81300457 ; 2012BAI32B01 ; 2011CB944504
资助机构National Natural Science Foundation of China ; National Key Technology R&amp ; D Program in the Twelve Five-Year Plan ; Ministry of Science and Technology of China
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60476
专题北京大学第三临床医学院_生殖医学中心
北京大学第二临床医学院_麻醉科
北京大学第三临床医学院_妇产科
作者单位1.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Reprod Med Ctr, Beijing 100191, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Chun-mei,Zhao, Yue,Li, Rong,et al. Metabolic heterogeneity of follicular amino acids in polycystic ovary syndrome is affected by obesity and related to pregnancy outcome[J]. BMC PREGNANCY AND CHILDBIRTH,2014,14.
APA Zhang, Chun-mei.,Zhao, Yue.,Li, Rong.,Yu, Yang.,Yan, Li-ying.,...&Qiao, Jie.(2014).Metabolic heterogeneity of follicular amino acids in polycystic ovary syndrome is affected by obesity and related to pregnancy outcome.BMC PREGNANCY AND CHILDBIRTH,14.
MLA Zhang, Chun-mei,et al."Metabolic heterogeneity of follicular amino acids in polycystic ovary syndrome is affected by obesity and related to pregnancy outcome".BMC PREGNANCY AND CHILDBIRTH 14(2014).
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