IR@PKUHSC  > 北京大学药学院  > 药剂学系
学科主题药学
Pharmacodynamics and pharmacokinetics of the insulin-mimetic agent vanadyl acetylacetonate in non-diabetic and diabetic rats
Zhang, SQ; Zhong, XY; Lu, WL; Zheng, L; Zhang, X; Sun, F; Fu, GY; Zhang, Q
关键词vanadyl acetylacetonate pharmacodynamics pharmacokinetics tissue distribution
刊名JOURNAL OF INORGANIC BIOCHEMISTRY
2005-05-01
DOI10.1016/j.jinorgbio.2005.01.015
99期:5页:1064-1075
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]BLOOD-GLUCOSE ; SULFATE ; COMPLEXES ; METABOLISM ; ABSORPTION ; LIGANDS
英文摘要

The objectives of this study were to evaluate the pharmacodynamics and pharmacokinetics of vanadyl acetylacetonate (VAC) in rats. Pharmacodynamic study was carried out using non-diabetic and diabetic rats by subcutaneous (s.c.) and intragastric (i.g.) administrations at single dose or multiple doses. Pharmacokinetic study was performed using non-diabetic rats. Results showed that VAC resulted in a significant decrease of plasma glucose levels in diabetic rats in all dosing levels, and nearly restored hyperglycemic values to normal values after s.c. injection at a single dose of 2, 4, and 8 mg vanadium (V)/kg, or after i.g. administration at multiple doses of 3 and 6 mg V/kg once daily for seven consecutive days, respectively. The VAC could be rapidly absorbed and T-max values ranged from 0.9 +/- 0.3 h for s.c. injection to 3.0 +/- 0.9 h for i.g. administration. The average absolute bioavailabilities for i.g. administrations at a single dose of 3, 6, and 10 mg V/kg were 34.7%, 28.1%, and 22.8%, respectively. After i.g. administration at a single dose of 10 mg V/kg, the average elimination half-lives obtained from non-diabetic rats were very long ranging from 144.7 +/- 8.7 h in plasma to 657.3 +/- 34.8 It in femur tissue. In conclusion, VAC widely distributed in various tissues and accumulated more in the femur tissue. The time to reach maximal vanadium level after s.c. injection or i.g. administration was not coincident with the time to reach maximal hypoglycemic effect. The accumulated vanadium in bone, kidney or other tissues may gradually release and exert a longer action. In present dosing levels and administration routes, VAC was effective for lowering plasma glucose levels in diabetic rats and could reverse the higher triglyceride and cholesterol levels to the normal ranges. VAC did not influence the insulin levels in plasma and not cause obvious toxic signs like diarrhea. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000228879200011
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60478
Collection北京大学药学院_药剂学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Ctr Hlth Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
2.Affiliated Hosp, Acad Mil Med Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Zhang, SQ,Zhong, XY,Lu, WL,et al. Pharmacodynamics and pharmacokinetics of the insulin-mimetic agent vanadyl acetylacetonate in non-diabetic and diabetic rats[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2005,99(5):1064-1075.
APA Zhang, SQ.,Zhong, XY.,Lu, WL.,Zheng, L.,Zhang, X.,...&Zhang, Q.(2005).Pharmacodynamics and pharmacokinetics of the insulin-mimetic agent vanadyl acetylacetonate in non-diabetic and diabetic rats.JOURNAL OF INORGANIC BIOCHEMISTRY,99(5),1064-1075.
MLA Zhang, SQ,et al."Pharmacodynamics and pharmacokinetics of the insulin-mimetic agent vanadyl acetylacetonate in non-diabetic and diabetic rats".JOURNAL OF INORGANIC BIOCHEMISTRY 99.5(2005):1064-1075.
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