|CT-guidance interstitial (125)Iodine seed brachytherapy as a salvage therapy for recurrent spinal primary tumors|
|Cao, Qianqian1; Wang, Hao1; Meng, Na1; Jiang, Yuliang1; Jiang, Ping1; Gao, Yang1; Tian, Suqing1; Liu, Chen2; Yang, Ruijie1; Wang, Junjie1; Zhang, Kaixian3|
|关键词||Brachytherapy I-125 seed implantation Primary spine tumors CT-guided Outcome|
|WOS标题词||Science & Technology|
|类目[WOS]||Oncology ; Radiology, Nuclear Medicine & Medical Imaging|
|研究领域[WOS]||Oncology ; Radiology, Nuclear Medicine & Medical Imaging|
|关键词[WOS]||DOSE-RATE BRACHYTHERAPY ; PERCUTANEOUS VERTEBROPLASTY ; CLINICAL-EXPERIENCE ; SINGLE INSTITUTION ; CORD COMPRESSION ; RADIOSURGERY ; METASTASES ; IMPLANTATION ; SURGERY ; CANCER|
Background: Management of spinal neoplasms has relied on open surgery and external beam radiotherapy (EBRT). Although primary spinal tumors are rare, their treatment remains a pervasive problem. This analysis sought to evaluate the safety and efficacy of CT-guided I-125 seed brachytherapy for recurrent paraspinous and vertebral primary tumors.
Methods: From November 2002 to June 2014, 17 patients who met the inclusion criteria were retrospectively reviewed. 14 (82.4%) had previously undergone surgery, 15 (88.2%) had received conventional EBRT and 3 (17.6%) had chosen chemotherapy. The number of I-125 seeds implanted ranged from 7 to 122 (median 79) with specific activity of 0.5-0.8 mCi (median 0.7 mCi). The post-plan showed that the actuarial D-90 of I-125 seeds were 90-183 Gy (median 137 Gy). The follow-up period ranged from 2 to 69 months (median 19 months). The local control rate was calculated by the Kaplan-Meier method.
Results: For 5 Chondrosarcomas, the 1-, 2-, 3-year local control rates were 75%, 37.5%, and 37.5%, respectively, with a median of 34 months (range, 4-39 months). For 4 chordomas, the local control rate was 50% with a median follow-up of 13 months (range, 3-17 months). For 3 fibromatosis, all of them were survival without local recurrence at the end of follow-up. During the follow-up period, 35.3% (6/17) died from metastases, 17.6% (3/17) developed local recurrence by 8, 14 and 34 months while 64.7% (11/17) remained alive. 100% experienced pain relief and normal or improved ambulation, without more than Frankel grade 3 radiation myelopathy.
Conclusions: Percutaneous I-125 seed implantation can be an alternative or retreatment for recurrent spinal primary tumors.
|资助机构||specialized research fund for the doctoral program of higher education|
|作者单位||1.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China|
2.Peking Univ, Hosp 3, Dept Radiat Oncol, Ctr Canc, Beijing 100191, Peoples R China
3.Tengzhou Cent Peoples Hosp, Ctr Canc, Tengzhou City 277500, Shangdong Provi, Peoples R China
|Cao, Qianqian,Wang, Hao,Meng, Na,et al. CT-guidance interstitial (125)Iodine seed brachytherapy as a salvage therapy for recurrent spinal primary tumors[J]. RADIATION ONCOLOGY,2014,9.|
|APA||Cao, Qianqian.,Wang, Hao.,Meng, Na.,Jiang, Yuliang.,Jiang, Ping.,...&Zhang, Kaixian.(2014).CT-guidance interstitial (125)Iodine seed brachytherapy as a salvage therapy for recurrent spinal primary tumors.RADIATION ONCOLOGY,9.|
|MLA||Cao, Qianqian,et al."CT-guidance interstitial (125)Iodine seed brachytherapy as a salvage therapy for recurrent spinal primary tumors".RADIATION ONCOLOGY 9(2014).|