IR@PKUHSC  > 北京大学第三临床医学院  > 肿瘤放疗科
学科主题临床医学
CT-guidance interstitial (125)Iodine seed brachytherapy as a salvage therapy for recurrent spinal primary tumors
Cao, Qianqian1; Wang, Hao1; Meng, Na1; Jiang, Yuliang1; Jiang, Ping1; Gao, Yang1; Tian, Suqing1; Liu, Chen2; Yang, Ruijie1; Wang, Junjie1; Zhang, Kaixian3
关键词Brachytherapy I-125 seed implantation Primary spine tumors CT-guided Outcome
刊名RADIATION ONCOLOGY
2014-12-23
DOI10.1186/s13014-014-0301-8
9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Radiology, Nuclear Medicine & Medical Imaging
资助者specialized research fund for the doctoral program of higher education ; specialized research fund for the doctoral program of higher education
研究领域[WOS]Oncology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]DOSE-RATE BRACHYTHERAPY ; PERCUTANEOUS VERTEBROPLASTY ; CLINICAL-EXPERIENCE ; SINGLE INSTITUTION ; CORD COMPRESSION ; RADIOSURGERY ; METASTASES ; IMPLANTATION ; SURGERY ; CANCER
英文摘要

Background: Management of spinal neoplasms has relied on open surgery and external beam radiotherapy (EBRT). Although primary spinal tumors are rare, their treatment remains a pervasive problem. This analysis sought to evaluate the safety and efficacy of CT-guided I-125 seed brachytherapy for recurrent paraspinous and vertebral primary tumors.

Methods: From November 2002 to June 2014, 17 patients who met the inclusion criteria were retrospectively reviewed. 14 (82.4%) had previously undergone surgery, 15 (88.2%) had received conventional EBRT and 3 (17.6%) had chosen chemotherapy. The number of I-125 seeds implanted ranged from 7 to 122 (median 79) with specific activity of 0.5-0.8 mCi (median 0.7 mCi). The post-plan showed that the actuarial D-90 of I-125 seeds were 90-183 Gy (median 137 Gy). The follow-up period ranged from 2 to 69 months (median 19 months). The local control rate was calculated by the Kaplan-Meier method.

Results: For 5 Chondrosarcomas, the 1-, 2-, 3-year local control rates were 75%, 37.5%, and 37.5%, respectively, with a median of 34 months (range, 4-39 months). For 4 chordomas, the local control rate was 50% with a median follow-up of 13 months (range, 3-17 months). For 3 fibromatosis, all of them were survival without local recurrence at the end of follow-up. During the follow-up period, 35.3% (6/17) died from metastases, 17.6% (3/17) developed local recurrence by 8, 14 and 34 months while 64.7% (11/17) remained alive. 100% experienced pain relief and normal or improved ambulation, without more than Frankel grade 3 radiation myelopathy.

Conclusions: Percutaneous I-125 seed implantation can be an alternative or retreatment for recurrent spinal primary tumors.

语种英语
所属项目编号20120001110037
资助者specialized research fund for the doctoral program of higher education ; specialized research fund for the doctoral program of higher education
WOS记录号WOS:000351010600001
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60479
Collection北京大学第三临床医学院_肿瘤放疗科
作者单位1.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiat Oncol, Ctr Canc, Beijing 100191, Peoples R China
3.Tengzhou Cent Peoples Hosp, Ctr Canc, Tengzhou City 277500, Shangdong Provi, Peoples R China
Recommended Citation
GB/T 7714
Cao, Qianqian,Wang, Hao,Meng, Na,et al. CT-guidance interstitial (125)Iodine seed brachytherapy as a salvage therapy for recurrent spinal primary tumors[J]. RADIATION ONCOLOGY,2014,9.
APA Cao, Qianqian.,Wang, Hao.,Meng, Na.,Jiang, Yuliang.,Jiang, Ping.,...&Zhang, Kaixian.(2014).CT-guidance interstitial (125)Iodine seed brachytherapy as a salvage therapy for recurrent spinal primary tumors.RADIATION ONCOLOGY,9.
MLA Cao, Qianqian,et al."CT-guidance interstitial (125)Iodine seed brachytherapy as a salvage therapy for recurrent spinal primary tumors".RADIATION ONCOLOGY 9(2014).
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