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学科主题基础医学
Transcriptional upregulation of DNA polymerase beta by TEIF
Zhao, YJ; Zheng, H; Ling, Y; Hou, L; Zhang, B
关键词DNA polymerase beta hTERT telomerase transcription regulation
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2005-08-05
DOI10.1016/j.bbrc.2005.05.172
333期:3页:908-916
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]TELOMERASE REVERSE-TRANSCRIPTASE ; CAMP-RESPONSE-ELEMENT ; BASE EXCISION-REPAIR ; MAMMALIAN-CELLS ; CANCER-CELLS ; GENE ; PROMOTER ; OVEREXPRESSION ; INSTABILITY ; EXPRESSION
英文摘要

The overexpression of DNA polymerase beta (beta-pol) has been identified in lots of human cancers, but the mechanism has seldom been investigated. Telomerase transcriptional element-interacting factor (TEIF) can bind to hTERT promoter, stimulating its transcription and telomerase activities. Here, we report that TEIF could also enhance the expression of beta-pol at transcription level. TEIF could specifically activate transcription of beta-pol promoter, but not that of DNA polymerase alpha or delta promoter. The responsible sequences for binding of TEIF were revealed as GC-rich elements dispersing from +19 to -29 nt of beta-pol promoter, which due to mutations caused decreasing in binding of TEIF and apparent losing of transactivation activity. The in vivo interaction between TEIF and beta-pol promoter was identified by chromatin immunoprecipitation assay. Besides, ectopic expression of TEIF in HeLa cells could upregulate both levels of endogenous beta-pol mRNA and protein, and consequently increases resistance to the oxidative stress of H2O2. The data may provide new clue to the elucidation of beta-pol overexpression in cancers and also a functional link between beta-pol and telomerase. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000230418800034
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60483
专题北京大学基础医学院_病理学系
作者单位Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Zhao, YJ,Zheng, H,Ling, Y,et al. Transcriptional upregulation of DNA polymerase beta by TEIF[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2005,333(3):908-916.
APA Zhao, YJ,Zheng, H,Ling, Y,Hou, L,&Zhang, B.(2005).Transcriptional upregulation of DNA polymerase beta by TEIF.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,333(3),908-916.
MLA Zhao, YJ,et al."Transcriptional upregulation of DNA polymerase beta by TEIF".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 333.3(2005):908-916.
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