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学科主题: 基础医学
题名:
Transcriptional upregulation of DNA polymerase beta by TEIF
作者: Zhao, YJ; Zheng, H; Ling, Y; Hou, L; Zhang, B
关键词: DNA polymerase beta ; hTERT ; telomerase ; transcription regulation
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2005-08-05
DOI: 10.1016/j.bbrc.2005.05.172
卷: 333, 期:3, 页:908-916
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: TELOMERASE REVERSE-TRANSCRIPTASE ; CAMP-RESPONSE-ELEMENT ; BASE EXCISION-REPAIR ; MAMMALIAN-CELLS ; CANCER-CELLS ; GENE ; PROMOTER ; OVEREXPRESSION ; INSTABILITY ; EXPRESSION
英文摘要:

The overexpression of DNA polymerase beta (beta-pol) has been identified in lots of human cancers, but the mechanism has seldom been investigated. Telomerase transcriptional element-interacting factor (TEIF) can bind to hTERT promoter, stimulating its transcription and telomerase activities. Here, we report that TEIF could also enhance the expression of beta-pol at transcription level. TEIF could specifically activate transcription of beta-pol promoter, but not that of DNA polymerase alpha or delta promoter. The responsible sequences for binding of TEIF were revealed as GC-rich elements dispersing from +19 to -29 nt of beta-pol promoter, which due to mutations caused decreasing in binding of TEIF and apparent losing of transactivation activity. The in vivo interaction between TEIF and beta-pol promoter was identified by chromatin immunoprecipitation assay. Besides, ectopic expression of TEIF in HeLa cells could upregulate both levels of endogenous beta-pol mRNA and protein, and consequently increases resistance to the oxidative stress of H2O2. The data may provide new clue to the elucidation of beta-pol overexpression in cancers and also a functional link between beta-pol and telomerase. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000230418800034
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60483
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Zhao, YJ,Zheng, H,Ling, Y,et al. Transcriptional upregulation of DNA polymerase beta by TEIF[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2005,333(3):908-916.
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