IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科
学科主题临床医学
Effect of the number of lymph nodes harvested on the long-term survival of gastric cancer patients according to tumor stage and location: a 12-year study of 1,637 cases
Shen, Zhanlong; Ye, Yingjiang; Xie, Qiwei; Liang, Bin; Jiang, Kewei; Wang, Shan
关键词Gastric cancer Survival Lymph node harvest TNM stage Tumor location
刊名AMERICAN JOURNAL OF SURGERY
2015-09-01
DOI10.1016/j.amjsurg.2015.01.029
210期:3页:431-+
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
研究领域[WOS]Surgery
关键词[WOS]STOMACH ; JAPAN ; KOREA ; SIZE
英文摘要

BACKGROUND: The effect of the number of lymph nodes harvested on the long-term survival of gastric cancer according to Tumor, Node, and Metastasis (TNM) stage and tumor location remains unclear.

METHODS: Patients who underwent gastrectomy for gastric cancer (1998 to 2009) were evaluated retrospectively (1,637 patients). The patients′ clinicopathological variables, overall survival (OS), and progression-free survival (PFS) were recorded. The effect of the number of lymph nodes harvested on survival was analyzed according to TNM stage and tumor location.

RESULTS: Harvest of greater than 30 lymph nodes was associated with significantly better OS and PFS than less than or equal to 14 lymph nodes, but no significant difference was observed between less than or equal to 14 and 15 to 29 lymph nodes harvested. The number of lymph nodes harvested was significantly associated with the OS or/and PFS of late stage cancer (N+, T3 to T4, and stage III to IV), harvest of greater than 30 lymph nodes brought significantly better survival compared with the other 2 groups. A higher number of harvested lymph nodes was associated with significantly better PFS for gastric cancer of the body of stomach, but not for proximal, distal, and whole stomach cancer. When the tumor was located in the body of the stomach, the PFS was better with 15 to 29 lymph nodes than less than 14 lymph nodes; however, the OS and PFS were not significantly different between greater than 30 lymph nodes and 15 to 29 lymph nodes. TNM stage and number of lymph nodes harvested were the independent risk factors affecting the survival.

CONCLUSION: Tailored lymphadenectomy according to TNM stage and tumor location might be considered for gastric cancer patients. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000359597500004
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60486
专题北京大学第二临床医学院_胃肠外科
作者单位Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China
推荐引用方式
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Shen, Zhanlong,Ye, Yingjiang,Xie, Qiwei,et al. Effect of the number of lymph nodes harvested on the long-term survival of gastric cancer patients according to tumor stage and location: a 12-year study of 1,637 cases[J]. AMERICAN JOURNAL OF SURGERY,2015,210(3):431-+.
APA Shen, Zhanlong,Ye, Yingjiang,Xie, Qiwei,Liang, Bin,Jiang, Kewei,&Wang, Shan.(2015).Effect of the number of lymph nodes harvested on the long-term survival of gastric cancer patients according to tumor stage and location: a 12-year study of 1,637 cases.AMERICAN JOURNAL OF SURGERY,210(3),431-+.
MLA Shen, Zhanlong,et al."Effect of the number of lymph nodes harvested on the long-term survival of gastric cancer patients according to tumor stage and location: a 12-year study of 1,637 cases".AMERICAN JOURNAL OF SURGERY 210.3(2015):431-+.
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