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IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科  > 期刊论文
学科主题: 临床医学
题名:
Effect of the number of lymph nodes harvested on the long-term survival of gastric cancer patients according to tumor stage and location: a 12-year study of 1,637 cases
作者: Shen, Zhanlong; Ye, Yingjiang; Xie, Qiwei; Liang, Bin; Jiang, Kewei; Wang, Shan
关键词: Gastric cancer ; Survival ; Lymph node harvest ; TNM stage ; Tumor location
刊名: AMERICAN JOURNAL OF SURGERY
发表日期: 2015-09-01
DOI: 10.1016/j.amjsurg.2015.01.029
卷: 210, 期:3, 页:431-+
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: STOMACH ; JAPAN ; KOREA ; SIZE
英文摘要:

BACKGROUND: The effect of the number of lymph nodes harvested on the long-term survival of gastric cancer according to Tumor, Node, and Metastasis (TNM) stage and tumor location remains unclear.

METHODS: Patients who underwent gastrectomy for gastric cancer (1998 to 2009) were evaluated retrospectively (1,637 patients). The patients′ clinicopathological variables, overall survival (OS), and progression-free survival (PFS) were recorded. The effect of the number of lymph nodes harvested on survival was analyzed according to TNM stage and tumor location.

RESULTS: Harvest of greater than 30 lymph nodes was associated with significantly better OS and PFS than less than or equal to 14 lymph nodes, but no significant difference was observed between less than or equal to 14 and 15 to 29 lymph nodes harvested. The number of lymph nodes harvested was significantly associated with the OS or/and PFS of late stage cancer (N+, T3 to T4, and stage III to IV), harvest of greater than 30 lymph nodes brought significantly better survival compared with the other 2 groups. A higher number of harvested lymph nodes was associated with significantly better PFS for gastric cancer of the body of stomach, but not for proximal, distal, and whole stomach cancer. When the tumor was located in the body of the stomach, the PFS was better with 15 to 29 lymph nodes than less than 14 lymph nodes; however, the OS and PFS were not significantly different between greater than 30 lymph nodes and 15 to 29 lymph nodes. TNM stage and number of lymph nodes harvested were the independent risk factors affecting the survival.

CONCLUSION: Tailored lymphadenectomy according to TNM stage and tumor location might be considered for gastric cancer patients. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 81372290 ; 81372291 ; RDB 2012-18 ; RDB 2013-15
项目资助者: National Science Foundation of China ; Peking University People&prime ; s Hospital Research and Development Funds
WOS记录号: WOS:000359597500004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60486
Appears in Collections:北京大学第二临床医学院_胃肠外科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China

Recommended Citation:
Shen, Zhanlong,Ye, Yingjiang,Xie, Qiwei,et al. Effect of the number of lymph nodes harvested on the long-term survival of gastric cancer patients according to tumor stage and location: a 12-year study of 1,637 cases[J]. AMERICAN JOURNAL OF SURGERY,2015,210(3):431-+.
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