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学科主题: 临床医学
题名:
Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation
作者: Chang, Ying-Jun1,2; Zhao, Xiao-Yu1,2; Huang, Xiao-Jun1,2,3
关键词: Haploidentical transplantation ; Immune reconstitution ; Natural killer cell ; T cell
刊名: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
发表日期: 2014-04-01
DOI: 10.1016/j.bbmt.2013.11.028
卷: 20, 期:4, 页:440-449
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Immunology ; Transplantation
研究领域[WOS]: Hematology ; Immunology ; Transplantation
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; CORD BLOOD TRANSPLANTATION ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; IDENTICAL SIBLING TRANSPLANTATION ; SEVERE COMBINED IMMUNODEFICIENCY ; UNRELATED DONOR TRANSPLANTATION ; VERSUS-TUMOR ACTIVITY ; NATURAL-KILLER-CELLS ; RISK ACUTE-LEUKEMIA ; T-CELL
英文摘要:

Haploidentical hematopoietic stem cell transplantation (HSCT) offers the benefits of rapid and nearly universal donor availability and has been accepted worldwide as an alternative treatment for patients with hematologic malignancies who do not have a completely HLA-matched sibling or who require urgent transplantation. Unfortunately, serious infections and leukemia relapse resulting from slow immune reconstitution remain the 2 most frequent causes of mortality in patients undergoing haploidentical HSCT, particularly in those receiving extensively T cell depleted megadose CD34(+) allografts. This review summarizes advances in immune recovery after haploidentical HSCT, focusing on the immune subsets likely to have the greatest impact on clinical outcomes. The progress made in accelerating immune reconstitution using different strategies after haploidentical HSCT is also discussed. It is our belief that a predictive immune subset guided strategy to improve immune recovery might represent a future clinical direction. (c) 2014 American Society for Blood and Marrow Transplantation.

语种: 英语
所属项目编号: 81230013 ; Z121107002612035 ; Z121107002812033
项目资助者: Key Program of the National Natural Science Foundation of China ; Chang Jiang Scholars Program ; Bejing Municipal Science and Technology Commission
WOS记录号: WOS:000333322400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60489
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Inst Hematol, Beijing 100044, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China

Recommended Citation:
Chang, Ying-Jun,Zhao, Xiao-Yu,Huang, Xiao-Jun. Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2014,20(4):440-449.
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