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Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation
Chang, Ying-Jun1,2; Zhao, Xiao-Yu1,2; Huang, Xiao-Jun1,2,3
关键词Haploidentical transplantation Immune reconstitution Natural killer cell T cell
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2014-04-01
DOI10.1016/j.bbmt.2013.11.028
20期:4页:440-449
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; CORD BLOOD TRANSPLANTATION ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; IDENTICAL SIBLING TRANSPLANTATION ; SEVERE COMBINED IMMUNODEFICIENCY ; UNRELATED DONOR TRANSPLANTATION ; VERSUS-TUMOR ACTIVITY ; NATURAL-KILLER-CELLS ; RISK ACUTE-LEUKEMIA ; T-CELL
英文摘要

Haploidentical hematopoietic stem cell transplantation (HSCT) offers the benefits of rapid and nearly universal donor availability and has been accepted worldwide as an alternative treatment for patients with hematologic malignancies who do not have a completely HLA-matched sibling or who require urgent transplantation. Unfortunately, serious infections and leukemia relapse resulting from slow immune reconstitution remain the 2 most frequent causes of mortality in patients undergoing haploidentical HSCT, particularly in those receiving extensively T cell depleted megadose CD34(+) allografts. This review summarizes advances in immune recovery after haploidentical HSCT, focusing on the immune subsets likely to have the greatest impact on clinical outcomes. The progress made in accelerating immune reconstitution using different strategies after haploidentical HSCT is also discussed. It is our belief that a predictive immune subset guided strategy to improve immune recovery might represent a future clinical direction. (c) 2014 American Society for Blood and Marrow Transplantation.

语种英语
WOS记录号WOS:000333322400004
项目编号81230013 ; Z121107002612035 ; Z121107002812033
资助机构Key Program of the National Natural Science Foundation of China ; Chang Jiang Scholars Program ; Bejing Municipal Science and Technology Commission
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60489
专题北京大学第二临床医学院
北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Inst Hematol, Beijing 100044, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Chang, Ying-Jun,Zhao, Xiao-Yu,Huang, Xiao-Jun. Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2014,20(4):440-449.
APA Chang, Ying-Jun,Zhao, Xiao-Yu,&Huang, Xiao-Jun.(2014).Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,20(4),440-449.
MLA Chang, Ying-Jun,et al."Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 20.4(2014):440-449.
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