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学科主题: 口腔医学
题名:
Systemic Inflammation Markers in Patients With Aggressive Periodontitis: A Pilot Study
作者: Shi, Dong1,2; Meng, HuanXin1,2; Xu, Li1,2; Zhang, Li1,2; Chen, ZhiBin1,2; Feng, XiangHui1,2; Lu, RuiFang1,2; Sun, XiaoJun1,2; Ren, XiuYun1,2
关键词: Aggressive periodontitis ; pilot studies ; polymorphonuclear leukocytes
刊名: JOURNAL OF PERIODONTOLOGY
发表日期: 2008-12-01
DOI: 10.1902/jop.2008.080192
卷: 79, 期:12, 页:2340-2346
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: CORONARY-HEART-DISEASE ; MEAN PLATELET VOLUME ; C-REACTIVE PROTEIN ; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS ; LEUKOCYTE COUNT ; CARDIOVASCULAR-DISEASE ; MYOCARDIAL-INFARCTION ; ADULT PERIODONTITIS ; CELL COUNT ; RISK
英文摘要:

Background: The association between periodontitis and systemic health is evident; however, until recently, there was a lack of scientific evidence to define the relationship between aggressive periodontitis (AgP) and systemic conditions. The aim of this study was to explore the characteristics of peripheral blood cellular and serum protein parameters in patients with AgP.

Methods: Patients with AgP (n = 150) and healthy controls (n = 94) were recruited. Clinical parameters, including probing depth (PD), clinical attachment level (CAL), and percentage of severe sites, were examined. Blood cell variables, including leukocyte, neutrophil, and lymphocyte counts, as well as serum protein parameters, including total protein, albumin, globulin, and albumin/globulin ratio, were analyzed.

Results: Elevated neutrophil numbers and serum globulin levels were observed in patients with AgP compared to controls (4.22 +/- 1.81 x 10(9)/l versus 3.20 +/- 0.91 x 10(9)/l and 29.20 +/- 3.75 g/l versus 27.17 +/- 3.32 g/l, respectively; P <0.01). Albumin level and albumin/globulin ratio were lower in the AgP group than in the control group (47.65 +/- 2.45 g/l versus 48.88 +/- 2.13g/l and 1.66 +/- 0.24 versus 1.83 +/- 0.24, respectively; P<0.01). In the AgP group, neutrophil counts and serum globulin levels were positively correlated with clinical parameters, including mean values for PD, CAL, and percentage of severe sites (P<0.05); the albumin level and albumin/globulin ratio were inversely correlated with the clinical parameters as described above (P<0.05).

Conclusions: Patients with AgP may have elevated peripheral leukocyte numbers and serum globulin levels as well as decreased serum albumin levels and albumin/globulin ratios compared to controls. These changes might be associated with the severity of periodontal destruction. J Periodontol 2008; 79:2340-2346.

语种: 英语
所属项目编号: 30271411 ; 30471882 ; 2002AA217091
项目资助者: National Nature Science Foundation of China Beijing, China ; "985" Project of Peking University Center for Human Disease Genomics Beijing, China 2001 to 2008 ; National High Tech Program Beijing, China
WOS记录号: WOS:000261710900017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60495
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Hosp Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Shi, Dong,Meng, HuanXin,Xu, Li,et al. Systemic Inflammation Markers in Patients With Aggressive Periodontitis: A Pilot Study[J]. JOURNAL OF PERIODONTOLOGY,2008,79(12):2340-2346.
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