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学科主题口腔医学
Systemic Inflammation Markers in Patients With Aggressive Periodontitis: A Pilot Study
Shi, Dong1,2; Meng, HuanXin1,2; Xu, Li1,2; Zhang, Li1,2; Chen, ZhiBin1,2; Feng, XiangHui1,2; Lu, RuiFang1,2; Sun, XiaoJun1,2; Ren, XiuYun1,2
关键词Aggressive periodontitis pilot studies polymorphonuclear leukocytes
刊名JOURNAL OF PERIODONTOLOGY
2008-12-01
DOI10.1902/jop.2008.080192
79期:12页:2340-2346
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]CORONARY-HEART-DISEASE ; MEAN PLATELET VOLUME ; C-REACTIVE PROTEIN ; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS ; LEUKOCYTE COUNT ; CARDIOVASCULAR-DISEASE ; MYOCARDIAL-INFARCTION ; ADULT PERIODONTITIS ; CELL COUNT ; RISK
英文摘要

Background: The association between periodontitis and systemic health is evident; however, until recently, there was a lack of scientific evidence to define the relationship between aggressive periodontitis (AgP) and systemic conditions. The aim of this study was to explore the characteristics of peripheral blood cellular and serum protein parameters in patients with AgP.

Methods: Patients with AgP (n = 150) and healthy controls (n = 94) were recruited. Clinical parameters, including probing depth (PD), clinical attachment level (CAL), and percentage of severe sites, were examined. Blood cell variables, including leukocyte, neutrophil, and lymphocyte counts, as well as serum protein parameters, including total protein, albumin, globulin, and albumin/globulin ratio, were analyzed.

Results: Elevated neutrophil numbers and serum globulin levels were observed in patients with AgP compared to controls (4.22 +/- 1.81 x 10(9)/l versus 3.20 +/- 0.91 x 10(9)/l and 29.20 +/- 3.75 g/l versus 27.17 +/- 3.32 g/l, respectively; P <0.01). Albumin level and albumin/globulin ratio were lower in the AgP group than in the control group (47.65 +/- 2.45 g/l versus 48.88 +/- 2.13g/l and 1.66 +/- 0.24 versus 1.83 +/- 0.24, respectively; P<0.01). In the AgP group, neutrophil counts and serum globulin levels were positively correlated with clinical parameters, including mean values for PD, CAL, and percentage of severe sites (P<0.05); the albumin level and albumin/globulin ratio were inversely correlated with the clinical parameters as described above (P<0.05).

Conclusions: Patients with AgP may have elevated peripheral leukocyte numbers and serum globulin levels as well as decreased serum albumin levels and albumin/globulin ratios compared to controls. These changes might be associated with the severity of periodontal destruction. J Periodontol 2008; 79:2340-2346.

语种英语
WOS记录号WOS:000261710900017
项目编号30271411 ; 30471882 ; 2002AA217091
资助机构National Nature Science Foundation of China Beijing, China ; "985" Project of Peking University Center for Human Disease Genomics Beijing, China 2001 to 2008 ; National High Tech Program Beijing, China
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60495
专题北京大学口腔医学院
北京大学口腔医学院_牙周科
作者单位1.Peking Univ, Sch Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Hosp Stomatol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Shi, Dong,Meng, HuanXin,Xu, Li,et al. Systemic Inflammation Markers in Patients With Aggressive Periodontitis: A Pilot Study[J]. JOURNAL OF PERIODONTOLOGY,2008,79(12):2340-2346.
APA Shi, Dong.,Meng, HuanXin.,Xu, Li.,Zhang, Li.,Chen, ZhiBin.,...&Ren, XiuYun.(2008).Systemic Inflammation Markers in Patients With Aggressive Periodontitis: A Pilot Study.JOURNAL OF PERIODONTOLOGY,79(12),2340-2346.
MLA Shi, Dong,et al."Systemic Inflammation Markers in Patients With Aggressive Periodontitis: A Pilot Study".JOURNAL OF PERIODONTOLOGY 79.12(2008):2340-2346.
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