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学科主题: 精神卫生
题名:
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2
作者: Yue, Wei-Hua1,2; Wang, Hai-Feng3,4; Sun, Liang-Dan5,6,7; Tang, Fu-Lei1,2; Liu, Zhong-Hua8; Zhang, Hong-Xing9,10; Li, Wen-Qiang9,10; Zhang, Yan-Ling1,2; Zhang, Yang1,2; Ma, Cui-Cui11; Du, Bo12; Wang, Li-Fang1,2; Ren, Yun-Qing5,6,7; Yang, Yong-Feng9,10; Hu, Xiao-Feng1,2; Wang, Yi3,4; Deng, Wei13; Tan, Li-Wen14; Tan, Yun-Long15; Chen, Qi16; Xu, Guang-Ming17; Yang, Gui-Gang15; Zuo, Xian-bo5,6,7; Yan, Hao1,2; Ruan, Yan-Yan1,2; Lu, Tian-Lan1,2; Han, Xue14; Ma, Xiao-Hong13; Wang, Yan1,2; Cai, Li-Wei1,2; Jin, Chao11; Zhang, Hong-Yan1,2; Yan, Jun1,2; Mi, Wei-Feng1,2; Yin, Xian-Yong5,6,7; Ma, Wen-Bin11; Liu, Qi1,2; Kang, Lan1,2; Sun, Wei1,2; Pan, Cheng-Ying1,2; Shuang, Mei1,2; Yang, Fu-De15; Wang, Chuan-Yue16; Yang, Jian-Li17; Li, Ke-Qing12; Ma, Xin16; Li, Ling-Jiang14; Yu, Xin1,2; Li, Qi-Zhai18; Huang, Xun8; Lv, Lu-Xian9,10; Li, Tao13; Zhao, Guo-Ping3; Huang, Wei3,4; Zhang, Xue-Jun5,6,7; Zhang, Dai1,2
刊名: NATURE GENETICS
发表日期: 2011-12-01
DOI: 10.1038/ng.979
卷: 43, 期:12, 页:1228-U84
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: BIPOLAR DISORDER ; COMMON VARIANTS ; METAANALYSES ; PROTEIN ; DISEASE
英文摘要:

To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P-combined = 4.76 x 10(-11), odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P-combined = 6.91 x 10(-12), OR = 0.78; rs2142731 in an intron of PGBD1, P-combined = 5.14 x 10(-10), OR = 0.79) and 11p11.2 (rs11038167 near the 5′ UTR of TSPAN18, P-combined = 1.09 x 10(-11), OR = 1.29; rs11038172, P-combined = 7.21 x 10(-10), OR = 1.25; rs835784, P-combined = 2.73 x 10(-11), OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.

语种: 英语
所属项目编号: 2009AA022702 ; 30530290 ; 30870896 ; 81071087 ; 81071088 ; 2007CB512301 ; 2011CB707805 ; 2010DFB30820
项目资助者: National High-Tech Research and Development Program of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; International Science &amp ; Technology Cooperation Program of China
WOS记录号: WOS:000297931400017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60496
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
3.Chinese Natl Human Genome Ctr Shanghai, Shanghai Minist Sci & Technol China, Key Lab Hlth & Dis Genom, Shanghai, Peoples R China
4.Shanghai Jiao Tong Univ, State Key Lab Med Genom, Ruijin Hosp, Shanghai 200030, Peoples R China
5.Anhui Med Univ, Inst Dermatol, Hosp 1, Hefei, Peoples R China
6.Anhui Med Univ, Dept Dermatol, Hosp 1, Hefei, Peoples R China
7.Minist Sci & Technol, State Key Lab Dermatol, Hefei, Peoples R China
8.Chinese Acad Sci, Key Lab Mol & Dev Biol, Inst Genet & Dev Biol, Beijing, Peoples R China
9.Xinxiang Med Univ, Dept Psychiat, Affiliated Hosp 2, Xinxiang, Peoples R China
10.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China
11.Jinzhou Kangning Hosp, Jinzhou, Peoples R China
12.Hebei Mental Hlth Ctr, Baoding, Peoples R China
13.Sichuan Univ, Dept Psychiat, W China Hosp, Chengdu 610064, Peoples R China
14.Cent S Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha, Peoples R China
15.Beijing Huilongguan Hosp, Beijing, Peoples R China
16.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
17.Tianjin Municipal, Tianjin Anding Hosp, Tianjin, Peoples R China
18.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China

Recommended Citation:
Yue, Wei-Hua,Wang, Hai-Feng,Sun, Liang-Dan,et al. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2[J]. NATURE GENETICS,2011,43(12):1228-U84.
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