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学科主题: 药学
题名:
Isolation and identification of metabolites from dihydromyricetin
作者: Zhang, Yansong1,2; Que, Sheng1,2; Yang, Xiuwei1,2; Bin Wang1,2; Qiao, Liang3; Zhao, Yuying1,2
关键词: NMR ; metabolites ; dihydromyricetin-O-5-beta-D-glucuronide ; Ampelopsis grossedentata ; Rattan Tea
刊名: MAGNETIC RESONANCE IN CHEMISTRY
发表日期: 2007-11-01
DOI: 10.1002/mrc.2051
卷: 45, 期:11, 页:909-916
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Spectroscopy
研究领域[WOS]: Chemistry ; Spectroscopy
关键词[WOS]: CONSTITUENTS
英文摘要:

Dihydromyricetin (DHM) is the major bioactive constituent of Rattan Tea, which is the tender stems and leaves of Ampelopsis grossendentata. Seven metabolites (2-8) of DHM (1) were obtained by the chromatographic method. The metabolites 2-5 were obtained from the urine of rats administered orally with DHM; and metabolites 6-8 were detected in the fecal specimens of rats, which were also produced by human intestinal bacteria (HIB) in vitro, and were separated from the cultured media of HIB containing DHM. Their structures were elucidated as 5,7,3′,5′-tetrahydroxyflavanonol (2); 5,7,3′,5′-tetrahydroxy-4′-methoxyflavanonol (3); 5,7,4′,5′-tetrahydroxy-3′-methoxyflavanonol (4); and dihydromyricetin-O-5-beta-D-glucuronide (5); (2R,3S)-5,7,3′,4′,5′-pentahydroxyflavanonol (6); 3,4,5,7,3′,4′,5′-hepthydroxyflavan (7) and 5,7,3′,4′.5′-pentahydroxyflavanone (8) on the basis of UV, NMR and LC-MS/MS data. These seven metabolites were formed through familiar metabolic reactions. Dihydromyricetin-O-5-beta-D-glucuronide (5) is a new compound. The C-13-NMR data of (2) and (4) are reported for the first time. Copyright (c) 2007 John Wiley & Sons, Ltd.

语种: 英语
WOS记录号: WOS:000252666900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60500
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Peking Univ, Peking Univ Med & Hlth Anal Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, Yansong,Que, Sheng,Yang, Xiuwei,et al. Isolation and identification of metabolites from dihydromyricetin[J]. MAGNETIC RESONANCE IN CHEMISTRY,2007,45(11):909-916.
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