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Isolation and identification of metabolites from dihydromyricetin
Zhang, Yansong1,2; Que, Sheng1,2; Yang, Xiuwei1,2; Bin Wang1,2; Qiao, Liang3; Zhao, Yuying1,2
关键词NMR metabolites dihydromyricetin-O-5-beta-D-glucuronide Ampelopsis grossedentata Rattan Tea
刊名MAGNETIC RESONANCE IN CHEMISTRY
2007-11-01
DOI10.1002/mrc.2051
45期:11页:909-916
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Spectroscopy
研究领域[WOS]Chemistry ; Spectroscopy
关键词[WOS]CONSTITUENTS
英文摘要

Dihydromyricetin (DHM) is the major bioactive constituent of Rattan Tea, which is the tender stems and leaves of Ampelopsis grossendentata. Seven metabolites (2-8) of DHM (1) were obtained by the chromatographic method. The metabolites 2-5 were obtained from the urine of rats administered orally with DHM; and metabolites 6-8 were detected in the fecal specimens of rats, which were also produced by human intestinal bacteria (HIB) in vitro, and were separated from the cultured media of HIB containing DHM. Their structures were elucidated as 5,7,3′,5′-tetrahydroxyflavanonol (2); 5,7,3′,5′-tetrahydroxy-4′-methoxyflavanonol (3); 5,7,4′,5′-tetrahydroxy-3′-methoxyflavanonol (4); and dihydromyricetin-O-5-beta-D-glucuronide (5); (2R,3S)-5,7,3′,4′,5′-pentahydroxyflavanonol (6); 3,4,5,7,3′,4′,5′-hepthydroxyflavan (7) and 5,7,3′,4′.5′-pentahydroxyflavanone (8) on the basis of UV, NMR and LC-MS/MS data. These seven metabolites were formed through familiar metabolic reactions. Dihydromyricetin-O-5-beta-D-glucuronide (5) is a new compound. The C-13-NMR data of (2) and (4) are reported for the first time. Copyright (c) 2007 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000252666900002
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被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60500
专题北京大学药学院_天然药物学系
北京大学药学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Peking Univ, Peking Univ Med & Hlth Anal Ctr, Beijing 100083, Peoples R China
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Zhang, Yansong,Que, Sheng,Yang, Xiuwei,et al. Isolation and identification of metabolites from dihydromyricetin[J]. MAGNETIC RESONANCE IN CHEMISTRY,2007,45(11):909-916.
APA Zhang, Yansong,Que, Sheng,Yang, Xiuwei,Bin Wang,Qiao, Liang,&Zhao, Yuying.(2007).Isolation and identification of metabolites from dihydromyricetin.MAGNETIC RESONANCE IN CHEMISTRY,45(11),909-916.
MLA Zhang, Yansong,et al."Isolation and identification of metabolites from dihydromyricetin".MAGNETIC RESONANCE IN CHEMISTRY 45.11(2007):909-916.
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