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Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults: do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses?
Qin, Xianhui1; Li, Jianping2,3; Cui, Yimin4; Liu, Zeyuan5; Zhao, Zhigang6; Ge, Junbo7; Guan, Deming8; Hu, Jian9; Wang, Yanni10; Zhang, Fumin11; Xu, Xin12; Wang, Xiaobin13,14; Xu, Xiping1; Huo, Yong2,3
关键词folic acid supplementation methylenetetrahydrofolate reductase C677T polymorphisms methionine synthase A2756G polymorphisms
刊名PHARMACOGENETICS AND GENOMICS
2012-06-01
DOI10.1097/FPC.0b013e32834ac5e8
22期:6页:421-428
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Pharmacology & Pharmacy
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Pharmacology & Pharmacy
关键词[WOS]NEURAL-TUBE DEFECTS ; HOMOCYSTEINE CONCENTRATIONS ; CONTROLLED TRIAL ; DOUBLE-BLIND ; RISK-FACTOR ; SUPPLEMENTATION ; DISEASE ; WOMEN ; PREVENTION ; GENOTYPE
英文摘要

Objectives To assess the influence of individual methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase A2756G polymorphisms on the change of serum folate concentration in response to different dosages and durations of folic acid (FA) supplementation in hypertensive Chinese adults.

Methods A total of 480 patients with mild or moderate essential hypertension were randomly assigned to three treatment groups:(a) enalapril only (10 mg, control group); (b) enalapril FA tablet [10:0.4mg (10 mg of enalapril combined with 0.4mg of FA), low-FA group]; (c) enalapril FA tablet (10:0.8 mg, high-FA group), once daily for 8 weeks. Individual serum folate levels were measured at baseline, and at 4 and 8 weeks posttreatment.

Results After 4 or 8 weeks of treatment, increases in serum folate were seen across all genotypes and FA dosage groups. However, compared with patients with 677CC genotype, those with CT or TT genotype in the low-FA group and TT genotype in the high-FA group still had significantly lower folate concentrations, particularly women. In the low-FA group, patients with CT or TT genotype showed an attenuated response compared with those with CC genotype (median ratio of folate at week 8 to that at baseline:CC, 1.953 vs. CT, 1.755 or TT, 1.637, P < 0.01 for both). Such an attenuated response was not observed in the high-FA group. Yet, only in the high-FA group did serum folate appear to reach a plateau after 4 weeks of treatment in all three MTHFR 677 genotypes and the methionine synthase 2756 AG/GG genotype.

Conclusion We demonstrated that MTHFR C677T polymorphisms can not only affect serum folate levels at the baseline and post-FA treatment, but also therapeutic responses to various dosages and durations of FA supplementation. Pharmacogenetics and Genomics 22: 421-428 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000303769700003
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60509
专题北京大学第一临床医学院_心血管内科
作者单位1.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
2.Peking Univ First Hosp, Dept Cardiol, Beijing, Peoples R China
3.Peking Univ First Hosp, Ctr Heart, Beijing, Peoples R China
4.Peking Univ First Hosp, Dept Clin Pharmacol, Beijing, Peoples R China
5.Affiliated Hosp, Acad Mil Med Sci, Dept Pharm, Beijing, Peoples R China
6.Capital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing, Peoples R China
7.Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200433, Peoples R China
8.Harbin Med Univ, Clin Med Coll 1, Dept Cardiol, Harbin, Peoples R China
9.China Med Univ, Affiliated Hosp 1, Dept Cardiol, Shenyang, Peoples R China
10.Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Cardiol, Xian 710049, Peoples R China
11.Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China
12.Inst Biomed, Guangzhou, Guangdong, Peoples R China
13.NW Univ Feinberg Sch Med, Dept Pediat, Childrens Mem Hosp, Chicago, IL USA
14.NW Univ Feinberg Sch Med, Childrens Mem Res Ctr, Chicago, IL USA
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Qin, Xianhui,Li, Jianping,Cui, Yimin,et al. Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults: do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses?[J]. PHARMACOGENETICS AND GENOMICS,2012,22(6):421-428.
APA Qin, Xianhui.,Li, Jianping.,Cui, Yimin.,Liu, Zeyuan.,Zhao, Zhigang.,...&Huo, Yong.(2012).Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults: do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses?.PHARMACOGENETICS AND GENOMICS,22(6),421-428.
MLA Qin, Xianhui,et al."Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults: do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses?".PHARMACOGENETICS AND GENOMICS 22.6(2012):421-428.
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