北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults: do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses?
作者: Qin, Xianhui1; Li, Jianping2,3; Cui, Yimin4; Liu, Zeyuan5; Zhao, Zhigang6; Ge, Junbo7; Guan, Deming8; Hu, Jian9; Wang, Yanni10; Zhang, Fumin11; Xu, Xin12; Wang, Xiaobin13,14; Xu, Xiping1; Huo, Yong2,3
关键词: folic acid supplementation ; methylenetetrahydrofolate reductase C677T polymorphisms ; methionine synthase A2756G polymorphisms
刊名: PHARMACOGENETICS AND GENOMICS
发表日期: 2012-06-01
DOI: 10.1097/FPC.0b013e32834ac5e8
卷: 22, 期:6, 页:421-428
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity ; Pharmacology & Pharmacy
研究领域[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity ; Pharmacology & Pharmacy
关键词[WOS]: NEURAL-TUBE DEFECTS ; HOMOCYSTEINE CONCENTRATIONS ; CONTROLLED TRIAL ; DOUBLE-BLIND ; RISK-FACTOR ; SUPPLEMENTATION ; DISEASE ; WOMEN ; PREVENTION ; GENOTYPE
英文摘要:

Objectives To assess the influence of individual methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase A2756G polymorphisms on the change of serum folate concentration in response to different dosages and durations of folic acid (FA) supplementation in hypertensive Chinese adults.

Methods A total of 480 patients with mild or moderate essential hypertension were randomly assigned to three treatment groups:(a) enalapril only (10 mg, control group); (b) enalapril FA tablet [10:0.4mg (10 mg of enalapril combined with 0.4mg of FA), low-FA group]; (c) enalapril FA tablet (10:0.8 mg, high-FA group), once daily for 8 weeks. Individual serum folate levels were measured at baseline, and at 4 and 8 weeks posttreatment.

Results After 4 or 8 weeks of treatment, increases in serum folate were seen across all genotypes and FA dosage groups. However, compared with patients with 677CC genotype, those with CT or TT genotype in the low-FA group and TT genotype in the high-FA group still had significantly lower folate concentrations, particularly women. In the low-FA group, patients with CT or TT genotype showed an attenuated response compared with those with CC genotype (median ratio of folate at week 8 to that at baseline:CC, 1.953 vs. CT, 1.755 or TT, 1.637, P < 0.01 for both). Such an attenuated response was not observed in the high-FA group. Yet, only in the high-FA group did serum folate appear to reach a plateau after 4 weeks of treatment in all three MTHFR 677 genotypes and the methionine synthase 2756 AG/GG genotype.

Conclusion We demonstrated that MTHFR C677T polymorphisms can not only affect serum folate levels at the baseline and post-FA treatment, but also therapeutic responses to various dosages and durations of FA supplementation. Pharmacogenetics and Genomics 22: 421-428 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

语种: 英语
WOS记录号: WOS:000303769700003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60509
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
2.Peking Univ First Hosp, Dept Cardiol, Beijing, Peoples R China
3.Peking Univ First Hosp, Ctr Heart, Beijing, Peoples R China
4.Peking Univ First Hosp, Dept Clin Pharmacol, Beijing, Peoples R China
5.Affiliated Hosp, Acad Mil Med Sci, Dept Pharm, Beijing, Peoples R China
6.Capital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing, Peoples R China
7.Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200433, Peoples R China
8.Harbin Med Univ, Clin Med Coll 1, Dept Cardiol, Harbin, Peoples R China
9.China Med Univ, Affiliated Hosp 1, Dept Cardiol, Shenyang, Peoples R China
10.Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Cardiol, Xian 710049, Peoples R China
11.Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China
12.Inst Biomed, Guangzhou, Guangdong, Peoples R China
13.NW Univ Feinberg Sch Med, Dept Pediat, Childrens Mem Hosp, Chicago, IL USA
14.NW Univ Feinberg Sch Med, Childrens Mem Res Ctr, Chicago, IL USA

Recommended Citation:
Qin, Xianhui,Li, Jianping,Cui, Yimin,et al. Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults: do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses?[J]. PHARMACOGENETICS AND GENOMICS,2012,22(6):421-428.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Qin, Xianhui]'s Articles
[Li, Jianping]'s Articles
[Cui, Yimin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Qin, Xianhui]‘s Articles
[Li, Jianping]‘s Articles
[Cui, Yimin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace