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学科主题: 临床医学
题名:
Nonlaboratory-Based Risk Assessment Algorithm for Undiagnosed Type 2 Diabetes Developed on a Nation-Wide Diabetes Survey
作者: Zhou, Xianghai1,2; Qiao, Qing3,4; Ji, Linong1,2; Ning, Feng3; Yang, Wenying5; Weng, Jianping6; Shan, Zhongyan7; Tian, Haoming8; Ji, Qiuhe9; Lin, Lixiang10; Li, Qiang11; Xiao, Jianzhong5; Gao, Weiguo3,4; Pang, Zengchang12; Sun, Jianping12
刊名: DIABETES CARE
发表日期: 2013-12-01
DOI: 10.2337/dc13-0593
卷: 36, 期:12, 页:3944-3952
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: IMPAIRED FASTING GLUCOSE ; SCORE ; POPULATION ; PERFORMANCE ; PREVALENCE ; VALIDATION ; INDIANS ; INTER99 ; CHINA ; TESTS
英文摘要:

OBJECTIVETo develop a New Chinese Diabetes Risk Score for screening undiagnosed type 2 diabetes in China.RESEARCH DESIGN AND METHODSData from the China National Diabetes and Metabolic Disorders Study conducted from June 2007 to May 2008 comprising 16,525 men and 25,284 women aged 20-74 years were analyzed. Undiagnosed type 2 diabetes was detected based on fasting plasma glucose 7.0 mmol/L or 2-h plasma glucose 11.1 mmol/L in people without a prior history of diabetes. -Coefficients derived from a multiple logistic regression model predicting the presence of undiagnosed type 2 diabetes were used to calculate the New Chinese Diabetes Risk Score. The performance of the New Chinese Diabetes Risk Score was externally validated in two studies in Qingdao: one is prospective with follow-up from 2006 to 2009 (validation 1) and another cross-sectional conducted in 2009 (validation 2).RESULTSThe New Chinese Diabetes Risk Score includes age, sex, waist circumference, BMI, systolic blood pressure, and family history of diabetes. The score ranges from 0 to 51. The area under the receiver operating curve of the score for undiagnosed type 2 diabetes was 0.748 (0.739-0.756) in the exploratory population, 0.725 (0.683-0.767) in validation 1, and 0.702 (0.680-0.724) in validation 2. At the optimal cutoff value of 25, the sensitivity and specificity of the score for predicting undiagnosed type 2 diabetes were 92.3 and 35.5%, respectively, in validation 1 and 86.8 and 38.8% in validation 2.CONCLUSIONSThe New Chinese Diabetes Risk Score based on nonlaboratory data appears to be a reliable screening tool to detect undiagnosed type 2 diabetes in Chinese population.

语种: 英语
所属项目编号: 2009BAI80B02 ; 2012AA02A509
项目资助者: Chinese Medical Association Foundation ; Chinese Diabetes Society ; National Key Technologies R&amp ; D Program of China ; National High-Tech R&amp ; D Program of China (863 Program)
WOS记录号: WOS:000327211500042
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60514
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.China Japan Friendship Hosp, Beijing, Peoples R China
2.Sichuan Univ, West China Hosp, Chengdu 610064, Peoples R China
3.Fujian Prov Hosp, Fuzhou, Peoples R China
4.Harbin Med Univ, Affiliated Hosp 2, Harbin, Peoples R China
5.Qingdao Municipal Ctr Dis Control & Prevent, Qingdao, Peoples R China
6.Peking Univ, Ctr Diabet, Beijing 100871, Peoples R China
7.Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
8.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China
9.Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Diabet Prevent Unit, Helsinki, Finland
10.Sun Yat Sen Univ, Hosp 3, Guangzhou 510275, Guangdong, Peoples R China
11.Chinese Med Univ, Affiliated Hosp 1, Shenyang, Peoples R China
12.Fourth Mil Med Univ, Xijing Hosp, Xian 710032, Peoples R China

Recommended Citation:
Zhou, Xianghai,Qiao, Qing,Ji, Linong,et al. Nonlaboratory-Based Risk Assessment Algorithm for Undiagnosed Type 2 Diabetes Developed on a Nation-Wide Diabetes Survey[J]. DIABETES CARE,2013,36(12):3944-3952.
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