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Resveratrol inhibits interleukin 1 beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappa B activity
Lei Ming1,5; Wang Ji-guo2; Xiao De-ming3; Fan Meng4; Wang Da-ping5; Xiong Jian-yi5; Chen Yang5; Ding Yue1; Liu Shang-li1
关键词SIRT1 Resveratrol Inducible nitric oxide synthase Nuclear factor-kappa B Articular chondrocytes
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2012-01-15
DOI10.1016/j.ejphar.2011.10.015
674期:2-3页:73-79
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]OSTEOARTHRITIS IN-VIVO ; CELL-SURVIVAL ; SELECTIVE-INHIBITION ; APOPTOSIS ; INFLAMMATION ; TRANSCRIPTION ; PROGRESSION ; DEACETYLASE ; ARTHRITIS ; CARTILAGE
英文摘要

In chondrocytes, resveratrol, a natural SIRT1 activator, exerts an anti-inflammatory response via inhibition of nuclear factor kappaB (NF-kappa B). Given that SIRT1 inhibits the transactivation potential of NF-kappa B by deacetylating acetylated lysines in p65, the NF-kappa B subunit, we investigated the effects of resveratrol-activated SIRT1 on articular chondrocytes. We found that when chondrocytes were stimulated with interleukin 1 beta (IL-1 beta), the time- and dose-dependent expression of inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production was suppressed by resveratrol. Resveratrol-activated SIRT1 mediated this suppression. SIRT1 suppressed not only the nuclear translocation of NF-kappa B but also the acetylation of p65. Furthermore, acetylated Lys310 in p65, which must be present for transactivation activity, was the immediate downstream target of SIRT1. Therefore, SIRT1 protects against the inflammatory response induced by IL-1 beta in articular chondrocytes. Resveratrol, as an activator of SIRT1, merits consideration as a therapeutic agent in the treatment and prevention of osteoarthritis. (C) 2011 Published by Elsevier B.V.

语种英语
WOS记录号WOS:000300200000002
项目编号SG200810200101A ; SG200810200102A ; 81101383
资助机构Shenzhen Bureau of Science Technology Information ; National Natural Science Foundation of China
引用统计
被引频次:54[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60518
专题北京大学深圳医院_骨关节外科
作者单位1.Tianjin First Ctr Hosp, Dept Orthoped, Tianjin 300192, Peoples R China
2.Sun Yat Sen Univ, Dept Orthoped, Sun Yat Sen Mem Hosp, Guangzhou 510120, Guangdong, Peoples R China
3.So Med Univ, Dept Rheumatol, Guangzhou 510515, Guangdong, Peoples R China
4.Peking Univ, Dept Orthoped, Shenzhen Hosp, Shenzhen 538016, Guangdong, Peoples R China
5.Shenzhen Second Peoples Hosp, Dept Orthoped, Shenzhen 518035, Guangdong, Peoples R China
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Lei Ming,Wang Ji-guo,Xiao De-ming,et al. Resveratrol inhibits interleukin 1 beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappa B activity[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2012,674(2-3):73-79.
APA Lei Ming.,Wang Ji-guo.,Xiao De-ming.,Fan Meng.,Wang Da-ping.,...&Liu Shang-li.(2012).Resveratrol inhibits interleukin 1 beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappa B activity.EUROPEAN JOURNAL OF PHARMACOLOGY,674(2-3),73-79.
MLA Lei Ming,et al."Resveratrol inhibits interleukin 1 beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappa B activity".EUROPEAN JOURNAL OF PHARMACOLOGY 674.2-3(2012):73-79.
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