北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学深圳医院  > 骨关节外科  > 期刊论文
学科主题: 临床医学
题名:
Resveratrol inhibits interleukin 1 beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappa B activity
作者: Lei Ming1,5; Wang Ji-guo2; Xiao De-ming3; Fan Meng4; Wang Da-ping5; Xiong Jian-yi5; Chen Yang5; Ding Yue1; Liu Shang-li1
关键词: SIRT1 ; Resveratrol ; Inducible nitric oxide synthase ; Nuclear factor-kappa B ; Articular chondrocytes
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2012-01-15
DOI: 10.1016/j.ejphar.2011.10.015
卷: 674, 期:2-3, 页:73-79
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: OSTEOARTHRITIS IN-VIVO ; CELL-SURVIVAL ; SELECTIVE-INHIBITION ; APOPTOSIS ; INFLAMMATION ; TRANSCRIPTION ; PROGRESSION ; DEACETYLASE ; ARTHRITIS ; CARTILAGE
英文摘要:

In chondrocytes, resveratrol, a natural SIRT1 activator, exerts an anti-inflammatory response via inhibition of nuclear factor kappaB (NF-kappa B). Given that SIRT1 inhibits the transactivation potential of NF-kappa B by deacetylating acetylated lysines in p65, the NF-kappa B subunit, we investigated the effects of resveratrol-activated SIRT1 on articular chondrocytes. We found that when chondrocytes were stimulated with interleukin 1 beta (IL-1 beta), the time- and dose-dependent expression of inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production was suppressed by resveratrol. Resveratrol-activated SIRT1 mediated this suppression. SIRT1 suppressed not only the nuclear translocation of NF-kappa B but also the acetylation of p65. Furthermore, acetylated Lys310 in p65, which must be present for transactivation activity, was the immediate downstream target of SIRT1. Therefore, SIRT1 protects against the inflammatory response induced by IL-1 beta in articular chondrocytes. Resveratrol, as an activator of SIRT1, merits consideration as a therapeutic agent in the treatment and prevention of osteoarthritis. (C) 2011 Published by Elsevier B.V.

语种: 英语
所属项目编号: SG200810200101A ; SG200810200102A ; 81101383
项目资助者: Shenzhen Bureau of Science Technology Information ; National Natural Science Foundation of China
WOS记录号: WOS:000300200000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60518
Appears in Collections:北京大学深圳医院_骨关节外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Tianjin First Ctr Hosp, Dept Orthoped, Tianjin 300192, Peoples R China
2.Sun Yat Sen Univ, Dept Orthoped, Sun Yat Sen Mem Hosp, Guangzhou 510120, Guangdong, Peoples R China
3.So Med Univ, Dept Rheumatol, Guangzhou 510515, Guangdong, Peoples R China
4.Peking Univ, Dept Orthoped, Shenzhen Hosp, Shenzhen 538016, Guangdong, Peoples R China
5.Shenzhen Second Peoples Hosp, Dept Orthoped, Shenzhen 518035, Guangdong, Peoples R China

Recommended Citation:
Lei Ming,Wang Ji-guo,Xiao De-ming,et al. Resveratrol inhibits interleukin 1 beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappa B activity[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2012,674(2-3):73-79.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Lei Ming]'s Articles
[Wang Ji-guo]'s Articles
[Xiao De-ming]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Lei Ming]‘s Articles
[Wang Ji-guo]‘s Articles
[Xiao De-ming]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace