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学科主题: 临床医学
题名:
Ethnic differences in the phenotypic expression of polycystic ovary syndrome
作者: Zhao, Yue; Qiao, Jie1
关键词: Polycystic ovary syndrome ; Ethnic differences ; Phenotypic expression
刊名: STEROIDS
发表日期: 2013-08-01
DOI: 10.1016/j.steroids.2013.04.006
卷: 78, 期:8, 页:755-760
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]: ABNORMAL GLUCOSE-TOLERANCE ; QUALITY-OF-LIFE ; 3-DIMENSIONAL ULTRASOUND FEATURES ; MEXICAN-AMERICAN WOMEN ; SOUTH ASIAN WOMEN ; METABOLIC SYNDROME ; INSULIN-RESISTANCE ; CHINESE WOMEN ; SYNDROME PCOS ; DIAGNOSTIC-CRITERIA
英文摘要:

Polycystic ovary syndrome (PCOS) is the most common endocrine problem affecting women of reproductive age and is investigated from many regions of the world. Some reports have indicated ethnic difference in its manifestation. This review addressed the evidences for ethnic variation in the expression of PCOS phenotypes and explored the potential ethnic-specific diagnosis of this syndrome. To determine ethnic variation, community prevalence and clinical and metabolic problems, including hyperandrogenism, oligomenorrhoea/amenorrhoea, polycystic ovaries, obesity, insulin resistance and the metabolic syndrome, had been compared from differing backgrounds and populations. Moreover, a link between ethnicity and variation in the metabolic phenotype of PCOS had also been identified. East Asian women with PCOS have a lower BMI and a milder hyperandrogenic phenotype, but with the highest prevalence of metabolic syndrome. South Asians in particular have a high prevalence of insulin resistance and metabolic syndrome, and are at risk for type 2 diabetes, with central obesity more than BMI reflecting their metabolic risk. African American and Hispanic women are more obese and more prone to metabolic problems. Besides, there is a higher prevalence of hirsutism among women of Middle Eastern and Mediterranean origin. Ethnically appropriate guidelines are needed for identifying anthropometric thresholds for better screening and diagnosis in high-risk ethnic groups. (C) 2013 Published by Elsevier Inc.

语种: 英语
所属项目编号: BMU20110159 ; 81170538
项目资助者: Program for Innovative Research Team in University of Ministry of Education of China ; National Natural Science Foundation of China
WOS记录号: WOS:000322294600006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60519
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Reprod Med Ctr, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
2.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China

Recommended Citation:
Zhao, Yue,Qiao, Jie. Ethnic differences in the phenotypic expression of polycystic ovary syndrome[J]. STEROIDS,2013,78(8):755-760.
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