IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation
Zha, Zhengbao3; Wang, Jinrui1,2; Qu, Enze1,2; Zhang, Shuhai3; Jin, Yushen3; Wang, Shumin1,2; Dai, Zhifei1,2
刊名SCIENTIFIC REPORTS
2013-08-05
DOI10.1038/srep02360
3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CONTRAST AGENTS ; CONDUCTING POLYMER ; DRUG-DELIVERY ; IN-VIVO ; NANOPARTICLES ; CANCER ; THERAPY ; MICELLES ; UNIFORM ; SYSTEM
英文摘要

Ultrasound (US) imaging provides a valuable opportunity to administer photothermal therapy (PTT) of cancer with real-time guidance to ensure proper targeting, but only a few theranostic agents were developed by physically grafting near infrared (NIR)-absorbing inorganic nanomaterials to ready-made ultrasound contrast agents (UCAs) for US imaging guided PTT. In this paper, NIR absorbing hollow microspheres were generated from polypyrrole merely using a facile one-step microemulsion method. It was found that the obtained polypyrrole hollow microspheres (PPyHMs) can act as an efficient theranostic agent not only to enhance US imaging greatly, but also exhibit excellent photohyperthermic effects. The contrast consistently sustained the echo signals for no less than 5 min and the NIR laser light ablated the tumor completely within two weeks in the presence of PPyHMs. More importantly, no use of additional NIR absorber substantially minimizes an onetime dose of the theranostic agent.

语种英语
WOS记录号WOS:000322698700010
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60522
Collection北京大学第三临床医学院
作者单位1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
3.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
Recommended Citation
GB/T 7714
Zha, Zhengbao,Wang, Jinrui,Qu, Enze,et al. Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation[J]. SCIENTIFIC REPORTS,2013,3.
APA Zha, Zhengbao.,Wang, Jinrui.,Qu, Enze.,Zhang, Shuhai.,Jin, Yushen.,...&Dai, Zhifei.(2013).Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation.SCIENTIFIC REPORTS,3.
MLA Zha, Zhengbao,et al."Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation".SCIENTIFIC REPORTS 3(2013).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Zha, Zhengbao]'s Articles
[Wang, Jinrui]'s Articles
[Qu, Enze]'s Articles
百度学术
百度学术Similar articles in
[Zha, Zhengbao]'s Articles
[Wang, Jinrui]'s Articles
[Qu, Enze]'s Articles
必应学术
必应学术Similar articles in
[Zha, Zhengbao]'s Articles
[Wang, Jinrui]'s Articles
[Qu, Enze]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.