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学科主题临床医学
Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation
Zha, Zhengbao3; Wang, Jinrui1,2; Qu, Enze1,2; Zhang, Shuhai3; Jin, Yushen3; Wang, Shumin1,2; Dai, Zhifei1,2
刊名SCIENTIFIC REPORTS
2013-08-05
DOI10.1038/srep02360
3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CONTRAST AGENTS ; CONDUCTING POLYMER ; DRUG-DELIVERY ; IN-VIVO ; NANOPARTICLES ; CANCER ; THERAPY ; MICELLES ; UNIFORM ; SYSTEM
英文摘要

Ultrasound (US) imaging provides a valuable opportunity to administer photothermal therapy (PTT) of cancer with real-time guidance to ensure proper targeting, but only a few theranostic agents were developed by physically grafting near infrared (NIR)-absorbing inorganic nanomaterials to ready-made ultrasound contrast agents (UCAs) for US imaging guided PTT. In this paper, NIR absorbing hollow microspheres were generated from polypyrrole merely using a facile one-step microemulsion method. It was found that the obtained polypyrrole hollow microspheres (PPyHMs) can act as an efficient theranostic agent not only to enhance US imaging greatly, but also exhibit excellent photohyperthermic effects. The contrast consistently sustained the echo signals for no less than 5 min and the NIR laser light ablated the tumor completely within two weeks in the presence of PPyHMs. More importantly, no use of additional NIR absorber substantially minimizes an onetime dose of the theranostic agent.

语种英语
所属项目编号81225011 ; 81230036
资助者National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China
WOS记录号WOS:000322698700010
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60522
专题北京大学第三临床医学院
作者单位1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
3.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
推荐引用方式
GB/T 7714
Zha, Zhengbao,Wang, Jinrui,Qu, Enze,et al. Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation[J]. SCIENTIFIC REPORTS,2013,3.
APA Zha, Zhengbao.,Wang, Jinrui.,Qu, Enze.,Zhang, Shuhai.,Jin, Yushen.,...&Dai, Zhifei.(2013).Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation.SCIENTIFIC REPORTS,3.
MLA Zha, Zhengbao,et al."Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation".SCIENTIFIC REPORTS 3(2013).
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