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学科主题: 临床医学
题名:
Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation
作者: Zha, Zhengbao3; Wang, Jinrui1,2; Qu, Enze1,2; Zhang, Shuhai3; Jin, Yushen3; Wang, Shumin1,2; Dai, Zhifei1,2
刊名: SCIENTIFIC REPORTS
发表日期: 2013-08-05
DOI: 10.1038/srep02360
卷: 3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: CONTRAST AGENTS ; CONDUCTING POLYMER ; DRUG-DELIVERY ; IN-VIVO ; NANOPARTICLES ; CANCER ; THERAPY ; MICELLES ; UNIFORM ; SYSTEM
英文摘要:

Ultrasound (US) imaging provides a valuable opportunity to administer photothermal therapy (PTT) of cancer with real-time guidance to ensure proper targeting, but only a few theranostic agents were developed by physically grafting near infrared (NIR)-absorbing inorganic nanomaterials to ready-made ultrasound contrast agents (UCAs) for US imaging guided PTT. In this paper, NIR absorbing hollow microspheres were generated from polypyrrole merely using a facile one-step microemulsion method. It was found that the obtained polypyrrole hollow microspheres (PPyHMs) can act as an efficient theranostic agent not only to enhance US imaging greatly, but also exhibit excellent photohyperthermic effects. The contrast consistently sustained the echo signals for no less than 5 min and the NIR laser light ablated the tumor completely within two weeks in the presence of PPyHMs. More importantly, no use of additional NIR absorber substantially minimizes an onetime dose of the theranostic agent.

语种: 英语
所属项目编号: 81225011 ; 81230036
项目资助者: National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China
WOS记录号: WOS:000322698700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60522
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
3.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China

Recommended Citation:
Zha, Zhengbao,Wang, Jinrui,Qu, Enze,et al. Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation[J]. SCIENTIFIC REPORTS,2013,3.
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