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学科主题临床医学
Total Peripheral Vascular Resistance, Cardiac Output, and Plasma C-Type Natriuretic Peptide Level in Children with Postural Tachycardia Syndrome
Li, Hongxia1; Han, Zhenhui2; Chen, Siyao1; Liao, Ying1; Wang, Yuli1; Liu, Ping1; Chen, Yonghong1; Tang, Chaoshu2,3; Lin, Jing1; Du, Junbao1,4; Jin, Hongfang1
刊名JOURNAL OF PEDIATRICS
2015-06-01
DOI10.1016/j.jpeds.2015.03.032
166期:6页:1385-+
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics
研究领域[WOS]Pediatrics
关键词[WOS]ORTHOSTATIC INTOLERANCE ; ADRENOMEDULLIN ; HEART ; VASODILATION ; ADOLESCENTS ; DIAGNOSIS ; RESPONSES ; EXERCISE ; SYNCOPE ; SYSTEM
英文摘要

Objective To investigate the total peripheral vascular resistance (TPVR), cardiac output (CO), and plasma C-type natriuretic peptide (CNP) levels in children with postural tachycardia syndrome (POTS) during supine, upright, and return to supine.

Study design Twenty-nine children with POTS, aged 12 +/- 3 years, were recruited, and 32 healthy children, aged 11 +/- 2 years, served as controls. Heart rate (HR), blood pressure, TPVR, and CO were continuously monitored with Finapres Medical System, and plasma CNP levels were detected with Sandwich immunoluminescence assay.

Results In children with POTS, upright TPVR and CO were significantly lower than those in supine position, and they rose again when they returned to supine position. However, in healthy control patients, both TPVR and CO did not change during supine, upright, and supine again positions. Also, in the supine position, there was no significant difference in TPVR and CO between POTS children and control subjects (P > .05). When upright, however, TPVR and CO in children with POTS were significantly lower than those of controls. Plasma CNP levels were significantly greater in children with POTS than that of controls (32.8 +/- 9.7 vs 24.2 +/- 8.4 [pg/mL], P < .01), and symptom scores and Delta HR positively correlated with plasma CNP levels in children with POTS (symptom scores: r = 0.490, P < .01; DHR: r = 0.508, P < .001), but CO negatively correlated with plasma CNP levels (r = -0.446, P < .01).

Conclusion Reduced TPVR and CO associated with the elevated plasma CNP might be involved in the pathogenesis of POTS.

语种英语
WOS记录号WOS:000355018200013
项目编号2012BA103B03 ; 2011CB503904 ; 2012BAI03B03 ; 81121061
资助机构Major Basic Research Project of China ; National Twelfth Five-Year Plan for Science &amp ; Technology Support ; National Natural Science Foundation of China
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60523
专题北京大学第一临床医学院_儿科
北京大学基础医学院
北京大学口腔医学院_口腔正畸科
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Kaifeng Childrens Hosp, Kaifeng, Henan, Peoples R China
3.Minist Educ, Key Lab Cardiovasc Sci, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China
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GB/T 7714
Li, Hongxia,Han, Zhenhui,Chen, Siyao,et al. Total Peripheral Vascular Resistance, Cardiac Output, and Plasma C-Type Natriuretic Peptide Level in Children with Postural Tachycardia Syndrome[J]. JOURNAL OF PEDIATRICS,2015,166(6):1385-+.
APA Li, Hongxia.,Han, Zhenhui.,Chen, Siyao.,Liao, Ying.,Wang, Yuli.,...&Jin, Hongfang.(2015).Total Peripheral Vascular Resistance, Cardiac Output, and Plasma C-Type Natriuretic Peptide Level in Children with Postural Tachycardia Syndrome.JOURNAL OF PEDIATRICS,166(6),1385-+.
MLA Li, Hongxia,et al."Total Peripheral Vascular Resistance, Cardiac Output, and Plasma C-Type Natriuretic Peptide Level in Children with Postural Tachycardia Syndrome".JOURNAL OF PEDIATRICS 166.6(2015):1385-+.
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