|Total Peripheral Vascular Resistance, Cardiac Output, and Plasma C-Type Natriuretic Peptide Level in Children with Postural Tachycardia Syndrome|
|Li, Hongxia1; Han, Zhenhui2; Chen, Siyao1; Liao, Ying1; Wang, Yuli1; Liu, Ping1; Chen, Yonghong1; Tang, Chaoshu2,3; Lin, Jing1; Du, Junbao1,4; Jin, Hongfang1|
|刊名||JOURNAL OF PEDIATRICS|
|WOS标题词||Science & Technology|
|关键词[WOS]||ORTHOSTATIC INTOLERANCE ; ADRENOMEDULLIN ; HEART ; VASODILATION ; ADOLESCENTS ; DIAGNOSIS ; RESPONSES ; EXERCISE ; SYNCOPE ; SYSTEM|
Objective To investigate the total peripheral vascular resistance (TPVR), cardiac output (CO), and plasma C-type natriuretic peptide (CNP) levels in children with postural tachycardia syndrome (POTS) during supine, upright, and return to supine.
Study design Twenty-nine children with POTS, aged 12 +/- 3 years, were recruited, and 32 healthy children, aged 11 +/- 2 years, served as controls. Heart rate (HR), blood pressure, TPVR, and CO were continuously monitored with Finapres Medical System, and plasma CNP levels were detected with Sandwich immunoluminescence assay.
Results In children with POTS, upright TPVR and CO were significantly lower than those in supine position, and they rose again when they returned to supine position. However, in healthy control patients, both TPVR and CO did not change during supine, upright, and supine again positions. Also, in the supine position, there was no significant difference in TPVR and CO between POTS children and control subjects (P > .05). When upright, however, TPVR and CO in children with POTS were significantly lower than those of controls. Plasma CNP levels were significantly greater in children with POTS than that of controls (32.8 +/- 9.7 vs 24.2 +/- 8.4 [pg/mL], P < .01), and symptom scores and Delta HR positively correlated with plasma CNP levels in children with POTS (symptom scores: r = 0.490, P < .01; DHR: r = 0.508, P < .001), but CO negatively correlated with plasma CNP levels (r = -0.446, P < .01).
Conclusion Reduced TPVR and CO associated with the elevated plasma CNP might be involved in the pathogenesis of POTS.
|项目编号||2012BA103B03 ; 2011CB503904 ; 2012BAI03B03 ; 81121061|
|资助机构||Major Basic Research Project of China ; National Twelfth Five-Year Plan for Science & ; Technology Support ; National Natural Science Foundation of China|
|作者单位||1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China|
2.Kaifeng Childrens Hosp, Kaifeng, Henan, Peoples R China
3.Minist Educ, Key Lab Cardiovasc Sci, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China
|Li, Hongxia,Han, Zhenhui,Chen, Siyao,et al. Total Peripheral Vascular Resistance, Cardiac Output, and Plasma C-Type Natriuretic Peptide Level in Children with Postural Tachycardia Syndrome[J]. JOURNAL OF PEDIATRICS,2015,166(6):1385-+.|
|APA||Li, Hongxia.,Han, Zhenhui.,Chen, Siyao.,Liao, Ying.,Wang, Yuli.,...&Jin, Hongfang.(2015).Total Peripheral Vascular Resistance, Cardiac Output, and Plasma C-Type Natriuretic Peptide Level in Children with Postural Tachycardia Syndrome.JOURNAL OF PEDIATRICS,166(6),1385-+.|
|MLA||Li, Hongxia,et al."Total Peripheral Vascular Resistance, Cardiac Output, and Plasma C-Type Natriuretic Peptide Level in Children with Postural Tachycardia Syndrome".JOURNAL OF PEDIATRICS 166.6(2015):1385-+.|
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