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学科主题临床医学
Overexpression of human telomerase reverse transcriptase promotes the motility and invasiveness of HepG2 cells in vitro
Chen, Peng-Cheng; Peng, Ji-Run; Huang, Lei; Li, Wen-Xia; Wang, Wen-Zhen; Cui, Zhu-Qing-Qing; Han, Hui; Gong, Lei; Xiang, Da-Peng; Qiao, Shi-Shi; Yu, Xin; Wei, Yu-Hua; Ma, Li-Ping; Li, Na; Zhu, Ji-Ye; Leng, Xi-Sheng
关键词telomerase human telomerase reverse transcriptase retroviral vector HepG2 motility invasiveness
刊名ONCOLOGY REPORTS
2013-09-01
DOI10.3892/or.2013.2563
30期:3页:1157-1164
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; TERMINAL TRANSFERASE ; PROGNOSTIC INDICATOR ; GENOMIC ANALYSIS ; GASTRIC-CANCER ; BREAST-CANCER ; LUNG-CANCER ; RHO-GTPASES ; EXPRESSION ; METASTASIS
英文摘要

Recent studies have indicated that telomerase activity promotes cancer invasion and metastasis, but the underlying mechanism remains unclear. Several studies have shown that expression of exogenous human telomerase reverse transcriptase (hTERT) can promote motility and invasiveness among telomerase-negative tumor cells, and inhibition of endogenous telomerase activity can reduce invasiveness in tumor cells. However, whether overexpression of hTERT can further enhance the motility and invasiveness of telomerase-positive tumor cells has yet to be determined. In the present study, we showed that stable overexpression of hTERT can increase telomerase activity and telomere length, which significantly promotes the invasive and metastatic potential of telomerase-positive HepG2 cells but does not affect cell proliferation. Further analysis suggested that enhanced invasiveness and metastasis may act through corresponding upregulation of mRNA and protein expression of matrix metalloproteinase 9 (MMP9) and Ras homolog gene family member C (RhoC). Our study indicated that exogenous expression of hTERT may promote invasiveness and metastasis through upregulation of MMP9 and RhoC.

语种英语
WOS记录号WOS:000322384700020
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60524
专题北京大学第二临床医学院
北京大学第二临床医学院_中心实验室
北京大学精神卫生研究所_精神科
作者单位Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
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GB/T 7714
Chen, Peng-Cheng,Peng, Ji-Run,Huang, Lei,et al. Overexpression of human telomerase reverse transcriptase promotes the motility and invasiveness of HepG2 cells in vitro[J]. ONCOLOGY REPORTS,2013,30(3):1157-1164.
APA Chen, Peng-Cheng.,Peng, Ji-Run.,Huang, Lei.,Li, Wen-Xia.,Wang, Wen-Zhen.,...&Leng, Xi-Sheng.(2013).Overexpression of human telomerase reverse transcriptase promotes the motility and invasiveness of HepG2 cells in vitro.ONCOLOGY REPORTS,30(3),1157-1164.
MLA Chen, Peng-Cheng,et al."Overexpression of human telomerase reverse transcriptase promotes the motility and invasiveness of HepG2 cells in vitro".ONCOLOGY REPORTS 30.3(2013):1157-1164.
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