IR@PKUHSC  > 北京大学药学院  > 天然药物学系
学科主题药学
Cerebral nuclei distribution study of dehydrodiisoeugenol as an anxiogenic agent determined by RP-HPLC
Zhang, You-Bo1,2; Zhu, Li-Qiao3; Yang, Xiu-Wei1,2
关键词Myristica fragrans Houtt Nutmeg Dehydrodiisoeugenol Cerebral nuclei distribution Column liquid chromatography
刊名FITOTERAPIA
2013
DOI10.1016/j.fitote.2012.09.022
84页:47-53
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者National Key Technology Research and Development Program of China ; National Natural Science Foundation of China ; "Major New Medicine Project" in Mega-projects of Science Research of China ; Beijing Municipal Special-Purpose Science Foundation of China ; National Key Technology Research and Development Program of China ; National Natural Science Foundation of China ; "Major New Medicine Project" in Mega-projects of Science Research of China ; Beijing Municipal Special-Purpose Science Foundation of China
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]MYRISTICA-FRAGRANS SEEDS ; MACE
英文摘要

A sensitive RP-HPLC-DAD method was established to quantify dehydrodiisoeugenol (DDIE) in rat cerebral nuclei. The assay procedure involved one-step extraction of DDIE and daidzein, as an internal standard, from rat plasma and various cerebral nuclei with ethyl acetate. Chromatographic separation was performed on a Diamonsil (TM) DOS C-18 column with methanol-water (81:19, v/v) as a mobile phase. The UV absorbance of the samples was measured at the wavelength of 270 nm. The analysis method was proved to be precise and accurate at linearity ranges in plasma and each cerebral nucleus with correlation coefficients of >= 0.9971. The results indicated that the method established was successfully applied to cerebral nuclei distribution study of DDIE after intravenous administration at a single dose of 40 mg/kg to rat. DDIE showed high concentration in all of cerebral nuclei at 8 min, which indicated that DDIE could cross the blood-brain barrier rapidly and might be one of the main bioactive substances of nutmeg. The results provide fundamental data for evaluating the effects of DDIE on the central nervous system and to be developed into an effective anxiogenic agent. (c) 2012 Elsevier B.V. All rights reserved.

语种英语
所属项目编号2011BAI07B08 ; 30973863 ; 81161120429 ; 2009ZX09301-010 ; Z0004105040311
资助者National Key Technology Research and Development Program of China ; National Natural Science Foundation of China ; "Major New Medicine Project" in Mega-projects of Science Research of China ; Beijing Municipal Special-Purpose Science Foundation of China ; National Key Technology Research and Development Program of China ; National Natural Science Foundation of China ; "Major New Medicine Project" in Mega-projects of Science Research of China ; Beijing Municipal Special-Purpose Science Foundation of China
WOS记录号WOS:000316531400008
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60528
专题北京大学药学院_天然药物学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
2.Peking Univ, Dept Nat Med, Sch Pharmaceut Sci, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Shandong Univ Tradit Chinese Med, Jinan, Peoples R China
推荐引用方式
GB/T 7714
Zhang, You-Bo,Zhu, Li-Qiao,Yang, Xiu-Wei. Cerebral nuclei distribution study of dehydrodiisoeugenol as an anxiogenic agent determined by RP-HPLC[J]. FITOTERAPIA,2013,84:47-53.
APA Zhang, You-Bo,Zhu, Li-Qiao,&Yang, Xiu-Wei.(2013).Cerebral nuclei distribution study of dehydrodiisoeugenol as an anxiogenic agent determined by RP-HPLC.FITOTERAPIA,84,47-53.
MLA Zhang, You-Bo,et al."Cerebral nuclei distribution study of dehydrodiisoeugenol as an anxiogenic agent determined by RP-HPLC".FITOTERAPIA 84(2013):47-53.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, You-Bo]的文章
[Zhu, Li-Qiao]的文章
[Yang, Xiu-Wei]的文章
百度学术
百度学术中相似的文章
[Zhang, You-Bo]的文章
[Zhu, Li-Qiao]的文章
[Yang, Xiu-Wei]的文章
必应学术
必应学术中相似的文章
[Zhang, You-Bo]的文章
[Zhu, Li-Qiao]的文章
[Yang, Xiu-Wei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。