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学科主题: 临床医学
题名:
Pharmacological Neuroprotection after Perinatal Hypoxic-Ischemic Brain Injury
作者: Fan, Xiyong1,2,3; Kavelaars, Annemieke2; Heijnen, Cobi J.2; Groenendaal, Floris1; van Bel, Frank1
关键词: Brain ; hypoxia ; ischemia ; neonate ; neuroprotection ; pharmacology
刊名: CURRENT NEUROPHARMACOLOGY
发表日期: 2010-12-01
卷: 8, 期:4, 页:324-334
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: NITRIC-OXIDE SYNTHASE ; LONG-TERM NEUROPROTECTION ; NEONATAL-RAT BRAIN ; HYPERBARIC-OXYGEN THERAPY ; MESENCHYMAL STEM-CELLS ; NF-KAPPA-B ; CEREBRAL-ISCHEMIA ; REPERFUSION INJURY ; BIRTH ASPHYXIA ; IN-VITRO
英文摘要:

Perinatal hypoxia-ischemia (HI) is an important cause of neonatal brain injury. Recent progress in the search for neuroprotective compounds has provided us with several promising drugs to reduce perinatal HI-induced brain injury. In the early stage (first 6 hours after birth) therapies are concentrated on prevention of the production of reactive oxygen species or free radicals (xanthine-oxidase-, nitric oxide synthase-, and prostaglandin inhibition), anti-inflammatory effects (erythropoietin, melatonin, Xenon) and anti-apoptotic interventions (nuclear factor kappa B-and c-jun N-terminal kinase inhibition); in a later stage stimulation of neurotrophic properties in the neonatal brain (erythropoietin, growth factors) can be targeted to promote neuronal and oligodendrocyte regeneration. Combination of pharmacological means of treatment with moderate hypothermia, which is accepted now as a meaningful therapy, is probably the next step in clinical treatment to fight post-asphyxial brain damage. Further studies should be directed at a more rational use of therapies by determining the optimal time and dose to inhibit the different potentially destructive molecular pathways or to enhance endogenous repair while at the same time avoiding adverse effects of the drugs used.

语种: 英语
WOS记录号: WOS:000284623500002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60529
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Univ Med Ctr, Dept Neonatol, Utrecht, Netherlands
2.Univ Med Ctr, Lab Neuroimmunol & Dev Origins Dis NIDOD, Utrecht, Netherlands
3.Peking Univ, Dept Paediat, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Fan, Xiyong,Kavelaars, Annemieke,Heijnen, Cobi J.,et al. Pharmacological Neuroprotection after Perinatal Hypoxic-Ischemic Brain Injury[J]. CURRENT NEUROPHARMACOLOGY,2010,8(4):324-334.
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