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Pharmacological Neuroprotection after Perinatal Hypoxic-Ischemic Brain Injury
Fan, Xiyong1,2,3; Kavelaars, Annemieke2; Heijnen, Cobi J.2; Groenendaal, Floris1; van Bel, Frank1
关键词Brain hypoxia ischemia neonate neuroprotection pharmacology
刊名CURRENT NEUROPHARMACOLOGY
2010-12-01
8期:4页:324-334
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]NITRIC-OXIDE SYNTHASE ; LONG-TERM NEUROPROTECTION ; NEONATAL-RAT BRAIN ; HYPERBARIC-OXYGEN THERAPY ; MESENCHYMAL STEM-CELLS ; NF-KAPPA-B ; CEREBRAL-ISCHEMIA ; REPERFUSION INJURY ; BIRTH ASPHYXIA ; IN-VITRO
英文摘要

Perinatal hypoxia-ischemia (HI) is an important cause of neonatal brain injury. Recent progress in the search for neuroprotective compounds has provided us with several promising drugs to reduce perinatal HI-induced brain injury. In the early stage (first 6 hours after birth) therapies are concentrated on prevention of the production of reactive oxygen species or free radicals (xanthine-oxidase-, nitric oxide synthase-, and prostaglandin inhibition), anti-inflammatory effects (erythropoietin, melatonin, Xenon) and anti-apoptotic interventions (nuclear factor kappa B-and c-jun N-terminal kinase inhibition); in a later stage stimulation of neurotrophic properties in the neonatal brain (erythropoietin, growth factors) can be targeted to promote neuronal and oligodendrocyte regeneration. Combination of pharmacological means of treatment with moderate hypothermia, which is accepted now as a meaningful therapy, is probably the next step in clinical treatment to fight post-asphyxial brain damage. Further studies should be directed at a more rational use of therapies by determining the optimal time and dose to inhibit the different potentially destructive molecular pathways or to enhance endogenous repair while at the same time avoiding adverse effects of the drugs used.

语种英语
WOS记录号WOS:000284623500002
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60529
专题北京大学第一临床医学院_儿科
作者单位1.Univ Med Ctr, Dept Neonatol, Utrecht, Netherlands
2.Univ Med Ctr, Lab Neuroimmunol & Dev Origins Dis NIDOD, Utrecht, Netherlands
3.Peking Univ, Dept Paediat, Hosp 1, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Fan, Xiyong,Kavelaars, Annemieke,Heijnen, Cobi J.,et al. Pharmacological Neuroprotection after Perinatal Hypoxic-Ischemic Brain Injury[J]. CURRENT NEUROPHARMACOLOGY,2010,8(4):324-334.
APA Fan, Xiyong,Kavelaars, Annemieke,Heijnen, Cobi J.,Groenendaal, Floris,&van Bel, Frank.(2010).Pharmacological Neuroprotection after Perinatal Hypoxic-Ischemic Brain Injury.CURRENT NEUROPHARMACOLOGY,8(4),324-334.
MLA Fan, Xiyong,et al."Pharmacological Neuroprotection after Perinatal Hypoxic-Ischemic Brain Injury".CURRENT NEUROPHARMACOLOGY 8.4(2010):324-334.
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