IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Id1 Expression Promotes T Regulatory Cell Differentiation by Facilitating TCR Costimulation
Liu, Chen1; Wang, Hong-Cheng2; Yu, Sen1; Jin, Rong1; Tang, Hui1; Liu, Yuan-Feng1; Ge, Qing1; Sun, Xiao-Hong2; Zhang, Yu1
刊名JOURNAL OF IMMUNOLOGY
2014-07-15
DOI10.4049/jimmunol.1302554
193期:2页:663-672
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]LOOP-HELIX PROTEINS ; TRANSCRIPTION FACTOR FOXP3 ; CUTTING EDGE ; TGF-BETA ; PRE-TCR ; CO-STIMULATION ; LYMPHOCYTE DEVELOPMENT ; AUTOIMMUNE-DISEASE ; T(H)17 CELLS ; CD28
英文摘要

T regulatory (Treg) cells play crucial roles in the regulation of cellular immunity. The development of Treg cells depends on signals from TCRs and IL-2Rs and is influenced by a variety of transcription factors. The basic helix-loop-helix proteins are known to influence TCR signaling thresholds. Whether this property impacts Treg differentiation is not understood. In this study, we interrogated the role of basic helix-loop-helix proteins in the production of Treg cells using the CD4 promoter-driven Id1 transgene. We found that Treg cells continued to accumulate as Id1 transgenic mice aged, resulting in a significant increase in Treg cell counts in the thymus as well as in the periphery compared with wild-type controls. Data from mixed bone marrow assays suggest that Id1 acts intrinsically on developing Treg cells. We made a connection between Id1 expression and CD28 costimulatory signaling because Id1 transgene expression facilitated the formation of Treg precursors in CD28(-/-) mice and the in vitro differentiation of Treg cells on thymic dendritic cells despite the blockade of costimulation by anti-CD80/CD86. Id1 expression also allowed in vitro Treg differentiation without anti-CD28 costimulation, which was at least in part due to enhanced production of IL-2. Notably, with full strength of costimulatory signals, however, Id1 expression caused modest but significant suppression of Treg induction. Finally, we demonstrate that Id1 transgenic mice were less susceptible to the induction of experimental autoimmune encephalomyelitis, thus illustrating the impact of Id1-mediated augmentation of Treg cell levels on cellular immunity.

语种英语
WOS记录号WOS:000338958300024
项目编号2011CB946100 ; 31330025 ; B07001 ; AI56129
资助机构National Basic Research Program of China ; National Natural Sciences Foundation of China ; 111 Project of China ; National Institutes of Health
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60530
专题北京大学基础医学院_免疫学系
作者单位1.Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
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Liu, Chen,Wang, Hong-Cheng,Yu, Sen,et al. Id1 Expression Promotes T Regulatory Cell Differentiation by Facilitating TCR Costimulation[J]. JOURNAL OF IMMUNOLOGY,2014,193(2):663-672.
APA Liu, Chen.,Wang, Hong-Cheng.,Yu, Sen.,Jin, Rong.,Tang, Hui.,...&Zhang, Yu.(2014).Id1 Expression Promotes T Regulatory Cell Differentiation by Facilitating TCR Costimulation.JOURNAL OF IMMUNOLOGY,193(2),663-672.
MLA Liu, Chen,et al."Id1 Expression Promotes T Regulatory Cell Differentiation by Facilitating TCR Costimulation".JOURNAL OF IMMUNOLOGY 193.2(2014):663-672.
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