北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 免疫学系  > 期刊论文
学科主题: 基础医学
题名:
Id1 Expression Promotes T Regulatory Cell Differentiation by Facilitating TCR Costimulation
作者: Liu, Chen1; Wang, Hong-Cheng2; Yu, Sen1; Jin, Rong1; Tang, Hui1; Liu, Yuan-Feng1; Ge, Qing1; Sun, Xiao-Hong2; Zhang, Yu1
刊名: JOURNAL OF IMMUNOLOGY
发表日期: 2014-07-15
DOI: 10.4049/jimmunol.1302554
卷: 193, 期:2, 页:663-672
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: LOOP-HELIX PROTEINS ; TRANSCRIPTION FACTOR FOXP3 ; CUTTING EDGE ; TGF-BETA ; PRE-TCR ; CO-STIMULATION ; LYMPHOCYTE DEVELOPMENT ; AUTOIMMUNE-DISEASE ; T(H)17 CELLS ; CD28
英文摘要:

T regulatory (Treg) cells play crucial roles in the regulation of cellular immunity. The development of Treg cells depends on signals from TCRs and IL-2Rs and is influenced by a variety of transcription factors. The basic helix-loop-helix proteins are known to influence TCR signaling thresholds. Whether this property impacts Treg differentiation is not understood. In this study, we interrogated the role of basic helix-loop-helix proteins in the production of Treg cells using the CD4 promoter-driven Id1 transgene. We found that Treg cells continued to accumulate as Id1 transgenic mice aged, resulting in a significant increase in Treg cell counts in the thymus as well as in the periphery compared with wild-type controls. Data from mixed bone marrow assays suggest that Id1 acts intrinsically on developing Treg cells. We made a connection between Id1 expression and CD28 costimulatory signaling because Id1 transgene expression facilitated the formation of Treg precursors in CD28(-/-) mice and the in vitro differentiation of Treg cells on thymic dendritic cells despite the blockade of costimulation by anti-CD80/CD86. Id1 expression also allowed in vitro Treg differentiation without anti-CD28 costimulation, which was at least in part due to enhanced production of IL-2. Notably, with full strength of costimulatory signals, however, Id1 expression caused modest but significant suppression of Treg induction. Finally, we demonstrate that Id1 transgenic mice were less susceptible to the induction of experimental autoimmune encephalomyelitis, thus illustrating the impact of Id1-mediated augmentation of Treg cell levels on cellular immunity.

语种: 英语
所属项目编号: 2011CB946100 ; 31330025 ; B07001 ; AI56129
项目资助者: National Basic Research Program of China ; National Natural Sciences Foundation of China ; 111 Project of China ; National Institutes of Health
WOS记录号: WOS:000338958300024
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60530
Appears in Collections:基础医学院_免疫学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
J Immunol-2014-Liu-663-72.pdf(1316KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Chen,Wang, Hong-Cheng,Yu, Sen,et al. Id1 Expression Promotes T Regulatory Cell Differentiation by Facilitating TCR Costimulation[J]. JOURNAL OF IMMUNOLOGY,2014,193(2):663-672.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Chen]'s Articles
[Wang, Hong-Cheng]'s Articles
[Yu, Sen]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Chen]‘s Articles
[Wang, Hong-Cheng]‘s Articles
[Yu, Sen]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新  !E

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace