IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Use of Clozapine in Older Asian Patients with Schizophrenia between 2001 and 2009
Xiang, Yu-Tao1,2; Buchanan, Robert W.3; Ungvari, Gabor S.4,5; Chiu, Helen F. K.1; Lai, Kelly Y. C.1; Li, You-Hong6,7; Si, Tian-Mei6,7; Wang, Chuan-Yue2; Lee, Edwin H. M.8; He, Yan-Ling9; Yang, Shu-Yu10; Chong, Mian-Yoon11,12; Kua, Ee-Heok13; Fujii, Senta14; Sim, Kang15; Yong, Michael K. H.16; Trivedi, Jitendra K.17; Chung, Eun-Kee18; Udomratn, Pichet19; Chee, Kok-Yoon20; Sartorius, Norman21; Tan, Chay-Hoon22; Shinfuku, Naotaka23
刊名PLOS ONE
2013-06-10
DOI10.1371/journal.pone.0066154
8期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]EAST-ASIA ; ATYPICAL ANTIPSYCHOTICS ; PRESCRIPTION
英文摘要

Background: To date there has been no large-scale international study that examined the use of clozapine in older patients with schizophrenia. This study examined the use of clozapine and its demographic and clinical correlates in older patients with schizophrenia in East Asia during the period between 2001 and 2009.

Method: Information on 1,157 hospitalized patients with schizophrenia aged 50 or older in five East Asian countries and territories (China, Hong Kong, Korea, Singapore and Taiwan) was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) project. Socio-demographic and clinical characteristics and prescription of psychotropic medications were recorded.

Results: Clozapine was prescribed for 20.6% of the pooled sample; 19.0% in 2001, 19.4% in 2004 and 22.9% in 2009. Multiple logistic regression analysis of the whole sample revealed that patients taking clozapine had a longer duration of illness, more negative symptoms and were less likely to receive first generation antipsychotic and anticholinergic drugs, but more likely to report weight gain compared to those not receiving clozapine. Compared to those in other sites, older patients in China were more likely to receive clozapine.

Conclusions: The prescription of clozapine for older Asian schizophrenia inpatients has remained at a stable level during the past decade. The appropriateness of use of clozapine in China needs to be further explored.

语种英语
WOS记录号WOS:000320440500065
项目编号81171270 ; 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
资助机构National Natural Science Foundation of China ; Beijing Nova Program of the Beijing Municipal Science and Technology Commission ; Chinese University of Hong Kong ; Institute of Mental Health Research in Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government in Taiwan
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60531
专题北京大学精神卫生研究所
作者单位1.Minist Mental Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Taipei City Hosp, Dept Pharm, Taipei, Taiwan
4.Kaohsiung Chang Gung Mem Hosp, Kaohsiung, Taiwan
5.Chang Gung Univ, Sch Med, Kaohsiung, Taiwan
6.Hyogo Inst Traumat Stress, Kobe, Hyogo, Japan
7.Inst Mental Hlth, Dept Gen Psychiat, Singapore, Singapore
8.Jurong Hlth Serv, Alexandra Hospital, Dept Med, Singapore, Singapore
9.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
10.Natl Seoul Hosp, Dept Psychiat, Seoul, South Korea
11.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland
12.Seinan Gakuin Univ, Sch Human Sci, Dept Social Welf, Fukuoka, Japan
13.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
14.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
15.Univ Maryland, Sch Med, Dept Psychiat, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USA
16.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
17.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
18.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
19.Shanghai Mental Hlth Ctr, Dept Psychiat Epidemiol, Shanghai, Peoples R China
20.Natl Univ Singapore, Dept Psychol Med, Singapore 117548, Singapore
21.Prince Songkla Univ, Fac Med, Dept Psychiat, Hat Yai, Thailand
22.Kuala Lumpur Hosp, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia
23.Natl Univ Singapore, Dept Pharmacol, Singapore 117548, Singapore
推荐引用方式
GB/T 7714
Xiang, Yu-Tao,Buchanan, Robert W.,Ungvari, Gabor S.,et al. Use of Clozapine in Older Asian Patients with Schizophrenia between 2001 and 2009[J]. PLOS ONE,2013,8(6).
APA Xiang, Yu-Tao.,Buchanan, Robert W..,Ungvari, Gabor S..,Chiu, Helen F. K..,Lai, Kelly Y. C..,...&Shinfuku, Naotaka.(2013).Use of Clozapine in Older Asian Patients with Schizophrenia between 2001 and 2009.PLOS ONE,8(6).
MLA Xiang, Yu-Tao,et al."Use of Clozapine in Older Asian Patients with Schizophrenia between 2001 and 2009".PLOS ONE 8.6(2013).
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