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学科主题: 精神卫生
题名:
Antipsychotic treatment in older schizophrenia patients with extrapyramidal side effects in Asia (2001-2009)
作者: Xiang, Yu-Tao1,2; Kreyenbuhl, Julie3,4; Dickerson, Faith B.5; Ungvari, Gabor S.6; Wang, Chuan-Yue2; Si, Tian-Mei7,8; Lee, Edwin H. M.1; Chiu, Helen F. K.1; Lai, Kelly Y. C.1; He, Yan-Ling9; Yang, Shu-Yu10; Chong, Mian-Yoon11,12; Tan, Chay-Hoon13; Kua, Ee-Heok13; Fujii, Senta14; Sim, Kang15; Yong, Michael K. H.15; Trivedi, Jitendra K.16; Chung, Eun-Kee17; Udomratn, Pichet18; Chee, Kok-Yoon19; Sartorius, Norman20; Shinfuku, Naotaka21
关键词: schizophrenia ; prescription patterns ; older patients ; extrapyramidal side effects
刊名: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
发表日期: 2012-07-01
DOI: 10.5414/CP201683
卷: 50, 期:7, 页:500-504
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: EAST-ASIA ; PRESCRIPTION
英文摘要:

Objective: This study surveyed the prescribing patterns of antipsychotic medications in Asian older schizophrenia patients with extrapyramidal side effects (EPS) during the period between 2001 and 2009. Method: Information on 848 hospitalized patients with schizophrenia aged 60 or older was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) study (2001 - 2009). Data from those patients with reported EPS from 8 Asian countries and territories including China, Hong Kong, Japan, Korea, Singapore, Taiwan, India and Malaysia were analyzed. The cross-sectional data of socio-demographic and clinical characteristics and antipsychotic prescriptions were collected using a standardized protocol and data collection procedure. Results: Of the 309/848 (36%) patients suffering from EPS, 210 patients (210/309; 68.0%) received at least one type of first generation antipsychotic (FGA), and 99 (99/309; 32.0%) received second generation antipsychotics (SGAs) only. Of SGAs prescribed in patients with EPS, risperidone was the most commonly used (100/309; 32.4%) followed by olanzapine (33/309; 10.7%) and quetiapine (25/309; 8.1%). Conclusions: FGAs were frequently used in Asian older schizophrenia patients with EPS. Considering the potential adverse effects of FGAs on existing EPS, the reasons for the frequent use of FGAs need to be urgently identified.

语种: 英语
所属项目编号: 81171270 ; 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; Chinese University of Hong Kong ; Institute of Mental Health, in Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government in Taiwan
WOS记录号: WOS:000307134300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60532
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Minist Mental Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
4.Taipei City Hosp, Taipei, Taiwan
5.Kaohsiung Chang Gung Mem Hosp, Kaohsiung, Taiwan
6.Chang Gung Univ, Sch Med, Guishan, Taiwan
7.Natl Univ Singapore, Singapore 117548, Singapore
8.HITS, Kobe, Hyogo, Japan
9.Inst Mental Hlth, Buangkok View, Singapore
10.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
11.Natl Seoul Hosp, Seoul, South Korea
12.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland
13.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan
14.MIRECC, Vet Adm Capitol Healthcare Network VISN 5, Baltimore, MD USA
15.Sheppard Pratt, Stanley Res Program, Baltimore, MD USA
16.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
17.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
18.Univ Maryland, Sch Med, Dept Psychiat, Div Res Serv, Baltimore, MD 21201 USA
19.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
20.Prince Songkla Univ, Fac Med, Dept Psychiat, Hat Yai, Thailand
21.Kuala Lumpur Hosp, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia

Recommended Citation:
Xiang, Yu-Tao,Kreyenbuhl, Julie,Dickerson, Faith B.,et al. Antipsychotic treatment in older schizophrenia patients with extrapyramidal side effects in Asia (2001-2009)[J]. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,2012,50(7):500-504.
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