IR@PKUHSC  > 北京大学精神卫生研究所
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Antipsychotic treatment in older schizophrenia patients with extrapyramidal side effects in Asia (2001-2009)
Xiang, Yu-Tao1,2; Kreyenbuhl, Julie3,4; Dickerson, Faith B.5; Ungvari, Gabor S.6; Wang, Chuan-Yue2; Si, Tian-Mei7,8; Lee, Edwin H. M.1; Chiu, Helen F. K.1; Lai, Kelly Y. C.1; He, Yan-Ling9; Yang, Shu-Yu10; Chong, Mian-Yoon11,12; Tan, Chay-Hoon13; Kua, Ee-Heok13; Fujii, Senta14; Sim, Kang15; Yong, Michael K. H.15; Trivedi, Jitendra K.16; Chung, Eun-Kee17; Udomratn, Pichet18; Chee, Kok-Yoon19; Sartorius, Norman20; Shinfuku, Naotaka21
关键词schizophrenia prescription patterns older patients extrapyramidal side effects
刊名INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
2012-07-01
DOI10.5414/CP201683
50期:7页:500-504
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]EAST-ASIA ; PRESCRIPTION
英文摘要

Objective: This study surveyed the prescribing patterns of antipsychotic medications in Asian older schizophrenia patients with extrapyramidal side effects (EPS) during the period between 2001 and 2009. Method: Information on 848 hospitalized patients with schizophrenia aged 60 or older was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) study (2001 - 2009). Data from those patients with reported EPS from 8 Asian countries and territories including China, Hong Kong, Japan, Korea, Singapore, Taiwan, India and Malaysia were analyzed. The cross-sectional data of socio-demographic and clinical characteristics and antipsychotic prescriptions were collected using a standardized protocol and data collection procedure. Results: Of the 309/848 (36%) patients suffering from EPS, 210 patients (210/309; 68.0%) received at least one type of first generation antipsychotic (FGA), and 99 (99/309; 32.0%) received second generation antipsychotics (SGAs) only. Of SGAs prescribed in patients with EPS, risperidone was the most commonly used (100/309; 32.4%) followed by olanzapine (33/309; 10.7%) and quetiapine (25/309; 8.1%). Conclusions: FGAs were frequently used in Asian older schizophrenia patients with EPS. Considering the potential adverse effects of FGAs on existing EPS, the reasons for the frequent use of FGAs need to be urgently identified.

语种英语
WOS记录号WOS:000307134300007
项目编号81171270 ; 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
资助机构National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; Chinese University of Hong Kong ; Institute of Mental Health, in Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government in Taiwan
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60532
专题北京大学精神卫生研究所
作者单位1.Minist Mental Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
4.Taipei City Hosp, Taipei, Taiwan
5.Kaohsiung Chang Gung Mem Hosp, Kaohsiung, Taiwan
6.Chang Gung Univ, Sch Med, Guishan, Taiwan
7.Natl Univ Singapore, Singapore 117548, Singapore
8.HITS, Kobe, Hyogo, Japan
9.Inst Mental Hlth, Buangkok View, Singapore
10.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
11.Natl Seoul Hosp, Seoul, South Korea
12.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland
13.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan
14.MIRECC, Vet Adm Capitol Healthcare Network VISN 5, Baltimore, MD USA
15.Sheppard Pratt, Stanley Res Program, Baltimore, MD USA
16.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
17.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
18.Univ Maryland, Sch Med, Dept Psychiat, Div Res Serv, Baltimore, MD 21201 USA
19.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
20.Prince Songkla Univ, Fac Med, Dept Psychiat, Hat Yai, Thailand
21.Kuala Lumpur Hosp, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia
推荐引用方式
GB/T 7714
Xiang, Yu-Tao,Kreyenbuhl, Julie,Dickerson, Faith B.,et al. Antipsychotic treatment in older schizophrenia patients with extrapyramidal side effects in Asia (2001-2009)[J]. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,2012,50(7):500-504.
APA Xiang, Yu-Tao.,Kreyenbuhl, Julie.,Dickerson, Faith B..,Ungvari, Gabor S..,Wang, Chuan-Yue.,...&Shinfuku, Naotaka.(2012).Antipsychotic treatment in older schizophrenia patients with extrapyramidal side effects in Asia (2001-2009).INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,50(7),500-504.
MLA Xiang, Yu-Tao,et al."Antipsychotic treatment in older schizophrenia patients with extrapyramidal side effects in Asia (2001-2009)".INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 50.7(2012):500-504.
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