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学科主题: 临床医学
题名:
The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification
作者: Cattran, Daniel C.2; Coppo, Rosanna3; Cook, H. Terence5; Feehally, John1; Roberts, Ian S. D.4; Troyanov, Stephan6; Alpers, Charles E.7; Amore, Alessandro3; Barratt, Jonathan1; Berthoux, Francois8; Bonsib, Stephen9; Bruijn, Jan A.10; D′ Agati, Vivette11; D′ Amico, Giuseppe12; Emancipator, Steven13; Emma, Francesco14; Ferrario, Franco15; Fervenza, Fernando C.16; Florquin, Sandrine17; Fogo, Agnes18; Geddes, Colin C.19; Groene, Hermann-Josef20; Haas, Mark21; Herzenberg, Andrew M.22,23; Hill, Prue A.24; Hogg, Ronald J.25; Hsu, Stephen I.26; Jennette, J. Charles27; Joh, Kensuke28; Julian, Bruce A.29; Kawamura, Tetsuya30; Lai, Fernand M.32; Leung, Chi Bon31; Li, Lei-Shi33; Li, Philip K. T.31; Liu, Zhi-Hong33; Mackinnon, Bruce19; Mezzano, Sergio34; Schena, F. Paolo35; Tomino, Yasuhiko36; Walker, Patrick D.37; Wang, Haiyan38; Weening, Jan J.39; Yoshikawa, Nori40; Zhang, Hong38; Int IgA Nephropathy Network; Renal Pathol Soc
关键词: glomerulonephritis ; IgA nephropathy ; Oxford classification ; pathology ; renal failure
刊名: KIDNEY INTERNATIONAL
发表日期: 2009-09-01
DOI: 10.1038/ki.2009.243
卷: 76, 期:5, 页:534-545
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GLOMERULAR-FILTRATION-RATE ; NATURAL-HISTORY ; RENAL-DISEASE ; PROTEINURIA ; PROGRESSION ; CHILDREN ; GLOMERULONEPHRITIS ; PROGNOSIS ; LESIONS ; ADULTS
英文摘要:

IgA nephropathy is the most common glomerular disease worldwide, yet there is no international consensus for its pathological or clinical classification. Here a new classification for IgA nephropathy is presented by an international consensus working group. The goal of this new system was to identify specific pathological features that more accurately predict risk of progression of renal disease in IgA nephropathy, thus enabling both clinicians and pathologists to improve individual patient prognostication. In a retrospective analysis, sequential clinical data were obtained on 265 adults and children with IgA nephropathy who were followed for a median of 5 years. Renal biopsies from all patients were scored by pathologists blinded to the clinical data for pathological variables identified as reproducible by an iterative process. Four of these variables: (1) the mesangial hypercellularity score, (2) segmental glomerulosclerosis, (3) endocapillary hypercellularity, and (4) tubular atrophy/interstitial fibrosis were subsequently shown to have independent value in predicting renal outcome. These specific pathological features withstood rigorous statistical analysis even after taking into account all clinical indicators available at the time of biopsy as well as during follow-up. The features have prognostic significance and we recommended they be taken into account for predicting outcome independent of the clinical features both at the time of presentation and during follow- up. The value of crescents was not addressed due to their low prevalence in the enrolled cohort.

语种: 英语
项目资助者: International Society of Nephrology, Kidney Research UK ; Vifor Pharma Aspreva
WOS记录号: WOS:000268957900011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60533
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Erasmus MC, Rotterdam, Netherlands
2.Wakayama Med Univ, Dept Pediat, Wakayama, Japan
3.Toronto Gen Res Inst, Univ Hlth Network, Toronto, ON, Canada
4.Univ London Imperial Coll Sci Technol & Med, London, England
5.Jikei Univ, Div Nephrol & Hypertens, Sch Med, Tokyo, Japan
6.Policlin, Renal Dialysis & Transplant Unit, Bari, Italy
7.Nephropathol Associates, Little Rock, AR USA
8.Leicester Gen Hosp, John Walls Renal Unit, Leicester LE5 4PW, Leics, England
9.Univ Turin, Nephrol Dialysis & Transplantat Unit, Regina Margherita Childrens Hosp, Turin, Italy
10.John Radcliffe Hosp, Dept Cellular Pathol, Oxford OX3 9DU, England
11.Univ Montreal, Hop Sacre Coeur Montreal, Quebec City, PQ, Canada
12.Univ Washington, Med Ctr, Dept Pathol, Seattle, WA 98195 USA
13.CHU St Etienne, Hop Nord, Dept Nephrol Dialysis & Renal Transplantat, St Etienne, France
14.LSU Hlth Sci Ctr, Dept Pathol, Shreveport, LA USA
15.Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands
16.Columbia Univ Coll Phys & Surg, Dept Pathol, New York, NY 10032 USA
17.Fdn DAmico Ric Malattie Renali, Milan, Italy
18.Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
19.Bambino Gesu Childrens Hosp & Res Inst, Div Nephrol & Dialysis, Dept Nephrol & Urol, Rome, Italy
20.San Carlo Borromeo Hosp, Renal Immunopathol Ctr, Milan, Italy
21.Mayo Clin, Div Nephrol & Hypertens, Rochester, MN USA
22.Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands
23.Vanderbilt Univ, Dept Pathol, Nashville, TN USA
24.Univ Glasgow, Western Infirm, Renal Unit, Glasgow G11 6NT, Lanark, Scotland
25.German Canc Res Ctr, Dept Cellular & Mol Pathol, D-6900 Heidelberg, Germany
26.Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
27.Univ Hlth Network, Dept Pathol, Toronto, ON, Canada
28.Univ Toronto, Toronto, ON M5S 1A1, Canada
29.St Vincents Hosp, Melbourne, Vic, Australia
30.Scott & White Med Ctr, Temple, TX USA
31.E Natl Hosp, Div Immunopathol, Clin Res Ctr Chiba, Chiba, Japan
32.Univ Florida, Coll Med, Div Nephrol Hypertens & Renal Transplantat, Gainesville, FL USA
33.Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA
34.Univ Alabama, Dept Med, Birmingham, AL 35294 USA
35.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
36.Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China
37.Nanjing Univ, Jinling Hosp, Sch Med, Res Inst Nephrol, Nanjing, Peoples R China
38.Univ Austral Chile, Dept Nefrol, Escuela Med, Valdivia, Chile
39.Juntendo Univ, Sch Med, Div Nephrol, Dept Internal Med, Tokyo 113, Japan
40.Peking Univ, Div Renal, Hosp 1, Inst Nephrol, Beijing 100871, Peoples R China

Recommended Citation:
Cattran, Daniel C.,Coppo, Rosanna,Cook, H. Terence,et al. The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification[J]. KIDNEY INTERNATIONAL,2009,76(5):534-545.
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