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学科主题: 公共卫生
题名:
Diameter Effects on Cytotoxicity of Multi-Walled Carbon Nanotubes
作者: Wang, X.1; Jia, G.1; Wang, H.2; Nie, H.2; Yan, L.1; Deng, X. Y.3; Wang, S.1
关键词: Cytotoxicity ; Alveolar Macrophages (AM) ; Diameter-Effect ; Apoptosis ; Multi-Walled Carbon Nanotubes (MWNTs)
刊名: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
发表日期: 2009-05-01
DOI: 10.1166/jnn.2009.025
卷: 9, 期:5, 页:3025-3033
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: IN-VIVO ; PULMONARY TOXICITY ; CELLS ; MICE ; BIODISTRIBUTION ; NANOMATERIALS ; ASSAYS
英文摘要:

In this work, we focus on the diameter effects on cytotoxicity of different diametered multi-walled carbon nanotubes (MWNTs). Cellular viability, phagocytotic ability, and apoptosis of guinea pig alveolar macrophages (AM) exposed to MWNTs were studied. MWNTs in smaller diameter showed less cytotoxicity than the larger ones at the same dosage. The phagocytosis ability of AM was partially impaired when the concentration of MWNTs was up to 20 mu g/ml, where a further characteristic feature of AM apoptosis was observed. The results indicate that MWNTs in different diameters exhibited quite different cytotoxicity, and for the first time revealed the diameter-effect of MWNTs on cytotoxicity.

语种: 英语
所属项目编号: 10490180 ; 30771787 ; 2006CB705604
项目资助者: Natural Science Foundation of China ; Minister of Science and Technology of China
WOS记录号: WOS:000265186800033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60542
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
3.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China

Recommended Citation:
Wang, X.,Jia, G.,Wang, H.,et al. Diameter Effects on Cytotoxicity of Multi-Walled Carbon Nanotubes[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2009,9(5):3025-3033.
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