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Diameter Effects on Cytotoxicity of Multi-Walled Carbon Nanotubes
Wang, X.1; Jia, G.1; Wang, H.2; Nie, H.2; Yan, L.1; Deng, X. Y.3; Wang, S.1
关键词Cytotoxicity Alveolar Macrophages (AM) Diameter-Effect Apoptosis Multi-Walled Carbon Nanotubes (MWNTs)
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
2009-05-01
DOI10.1166/jnn.2009.025
9期:5页:3025-3033
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]IN-VIVO ; PULMONARY TOXICITY ; CELLS ; MICE ; BIODISTRIBUTION ; NANOMATERIALS ; ASSAYS
英文摘要

In this work, we focus on the diameter effects on cytotoxicity of different diametered multi-walled carbon nanotubes (MWNTs). Cellular viability, phagocytotic ability, and apoptosis of guinea pig alveolar macrophages (AM) exposed to MWNTs were studied. MWNTs in smaller diameter showed less cytotoxicity than the larger ones at the same dosage. The phagocytosis ability of AM was partially impaired when the concentration of MWNTs was up to 20 mu g/ml, where a further characteristic feature of AM apoptosis was observed. The results indicate that MWNTs in different diameters exhibited quite different cytotoxicity, and for the first time revealed the diameter-effect of MWNTs on cytotoxicity.

语种英语
WOS记录号WOS:000265186800033
项目编号10490180 ; 30771787 ; 2006CB705604
资助机构Natural Science Foundation of China ; Minister of Science and Technology of China
引用统计
被引频次:58[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60542
专题北京大学公共卫生学院
北京大学基础医学院
北京大学公共卫生学院_公共卫生学院
北京大学第二临床医学院_肝病科
作者单位1.Peking Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
3.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
推荐引用方式
GB/T 7714
Wang, X.,Jia, G.,Wang, H.,et al. Diameter Effects on Cytotoxicity of Multi-Walled Carbon Nanotubes[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2009,9(5):3025-3033.
APA Wang, X..,Jia, G..,Wang, H..,Nie, H..,Yan, L..,...&Wang, S..(2009).Diameter Effects on Cytotoxicity of Multi-Walled Carbon Nanotubes.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,9(5),3025-3033.
MLA Wang, X.,et al."Diameter Effects on Cytotoxicity of Multi-Walled Carbon Nanotubes".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 9.5(2009):3025-3033.
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