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学科主题: 基础医学
题名:
Dynamic effects of leflunomide on IL-1, IL-6, and TNF-alpha activity produced from peritoneal macrophages in adjuvant arthritis rats
作者: Li, WD; Ran, GX; Teng, HL; Lin, ZB
关键词: leflunomide ; interleukin-1 ; interleukin-6 ; tumor necrosis factor ; macrophages ; adjuvant arthritis
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2002-08-01
卷: 23, 期:8, 页:752-756
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; RHEUMATOID-ARTHRITIS
英文摘要:

AIM: To investigate the effects of leflunomide (LEF) on modulating interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- alpha (TNF-alpha) production induced by lipopolysaccharide (LPS) in peritoneal macrophages (PMphi) in adjuvant arthritis rats and elucidate the possible mechanisms of antiinflammatory and antirheumatoid effects of LEF. METHODS: Freund′s complete adjuvant was injected in the hind footpad of rats to induce adjuvant arthritis (AA) rat model. The PMphi samples were taken at different time after medication. IL-1, IL-6, and TNF-alpha activities released from PMphi were measured by ELISA method or bioassay method. RESULTS: Production of IL-1, IL-6, and TNF-alpha was increased in the culture supernatant of PMphi in AA model rat. LEF could inhibit LPS-induced release of IL-1 and TNF-alpha from PMphi of the AA rats and the inhibitory effects were extremely rapid. LEF (10, 25 mg/kg) administrated for 21d could inhibit IL-6 release from PMphi in AA rats. CONCLUSION: The antiinflammatory mechanisms of LEF in AA rats might be related to inhibitory level of IL-1, IL-6, and TNF-alpha from PMphi in vivo.

语种: 英语
WOS记录号: WOS:000177314800013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60544
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Li, WD,Ran, GX,Teng, HL,et al. Dynamic effects of leflunomide on IL-1, IL-6, and TNF-alpha activity produced from peritoneal macrophages in adjuvant arthritis rats[J]. ACTA PHARMACOLOGICA SINICA,2002,23(8):752-756.
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