IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Dynamic effects of leflunomide on IL-1, IL-6, and TNF-alpha activity produced from peritoneal macrophages in adjuvant arthritis rats
Li, WD; Ran, GX; Teng, HL; Lin, ZB
关键词leflunomide interleukin-1 interleukin-6 tumor necrosis factor macrophages adjuvant arthritis
刊名ACTA PHARMACOLOGICA SINICA
2002-08-01
23期:8页:752-756
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]NECROSIS-FACTOR-ALPHA ; RHEUMATOID-ARTHRITIS
英文摘要

AIM: To investigate the effects of leflunomide (LEF) on modulating interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- alpha (TNF-alpha) production induced by lipopolysaccharide (LPS) in peritoneal macrophages (PMphi) in adjuvant arthritis rats and elucidate the possible mechanisms of antiinflammatory and antirheumatoid effects of LEF. METHODS: Freund′s complete adjuvant was injected in the hind footpad of rats to induce adjuvant arthritis (AA) rat model. The PMphi samples were taken at different time after medication. IL-1, IL-6, and TNF-alpha activities released from PMphi were measured by ELISA method or bioassay method. RESULTS: Production of IL-1, IL-6, and TNF-alpha was increased in the culture supernatant of PMphi in AA model rat. LEF could inhibit LPS-induced release of IL-1 and TNF-alpha from PMphi of the AA rats and the inhibitory effects were extremely rapid. LEF (10, 25 mg/kg) administrated for 21d could inhibit IL-6 release from PMphi in AA rats. CONCLUSION: The antiinflammatory mechanisms of LEF in AA rats might be related to inhibitory level of IL-1, IL-6, and TNF-alpha from PMphi in vivo.

语种英语
WOS记录号WOS:000177314800013
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60544
专题北京大学基础医学院_药理学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Li, WD,Ran, GX,Teng, HL,et al. Dynamic effects of leflunomide on IL-1, IL-6, and TNF-alpha activity produced from peritoneal macrophages in adjuvant arthritis rats[J]. ACTA PHARMACOLOGICA SINICA,2002,23(8):752-756.
APA Li, WD,Ran, GX,Teng, HL,&Lin, ZB.(2002).Dynamic effects of leflunomide on IL-1, IL-6, and TNF-alpha activity produced from peritoneal macrophages in adjuvant arthritis rats.ACTA PHARMACOLOGICA SINICA,23(8),752-756.
MLA Li, WD,et al."Dynamic effects of leflunomide on IL-1, IL-6, and TNF-alpha activity produced from peritoneal macrophages in adjuvant arthritis rats".ACTA PHARMACOLOGICA SINICA 23.8(2002):752-756.
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