学科主题 | 基础医学 |
Dynamic effects of leflunomide on IL-1, IL-6, and TNF-alpha activity produced from peritoneal macrophages in adjuvant arthritis rats | |
Li, WD; Ran, GX; Teng, HL; Lin, ZB | |
关键词 | leflunomide interleukin-1 interleukin-6 tumor necrosis factor macrophages adjuvant arthritis |
刊名 | ACTA PHARMACOLOGICA SINICA
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2002-08-01 | |
卷 | 23期:8页:752-756 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
研究领域[WOS] | Chemistry ; Pharmacology & Pharmacy |
关键词[WOS] | NECROSIS-FACTOR-ALPHA ; RHEUMATOID-ARTHRITIS |
英文摘要 | AIM: To investigate the effects of leflunomide (LEF) on modulating interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- alpha (TNF-alpha) production induced by lipopolysaccharide (LPS) in peritoneal macrophages (PMphi) in adjuvant arthritis rats and elucidate the possible mechanisms of antiinflammatory and antirheumatoid effects of LEF. METHODS: Freund′s complete adjuvant was injected in the hind footpad of rats to induce adjuvant arthritis (AA) rat model. The PMphi samples were taken at different time after medication. IL-1, IL-6, and TNF-alpha activities released from PMphi were measured by ELISA method or bioassay method. RESULTS: Production of IL-1, IL-6, and TNF-alpha was increased in the culture supernatant of PMphi in AA model rat. LEF could inhibit LPS-induced release of IL-1 and TNF-alpha from PMphi of the AA rats and the inhibitory effects were extremely rapid. LEF (10, 25 mg/kg) administrated for 21d could inhibit IL-6 release from PMphi in AA rats. CONCLUSION: The antiinflammatory mechanisms of LEF in AA rats might be related to inhibitory level of IL-1, IL-6, and TNF-alpha from PMphi in vivo. |
语种 | 英语 |
WOS记录号 | WOS:000177314800013 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/60544 |
Collection | 北京大学基础医学院_药理学系 |
作者单位 | Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100083, Peoples R China |
Recommended Citation GB/T 7714 | Li, WD,Ran, GX,Teng, HL,et al. Dynamic effects of leflunomide on IL-1, IL-6, and TNF-alpha activity produced from peritoneal macrophages in adjuvant arthritis rats[J]. ACTA PHARMACOLOGICA SINICA,2002,23(8):752-756. |
APA | Li, WD,Ran, GX,Teng, HL,&Lin, ZB.(2002).Dynamic effects of leflunomide on IL-1, IL-6, and TNF-alpha activity produced from peritoneal macrophages in adjuvant arthritis rats.ACTA PHARMACOLOGICA SINICA,23(8),752-756. |
MLA | Li, WD,et al."Dynamic effects of leflunomide on IL-1, IL-6, and TNF-alpha activity produced from peritoneal macrophages in adjuvant arthritis rats".ACTA PHARMACOLOGICA SINICA 23.8(2002):752-756. |
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