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Elective neck dissection versus observation in the management of early tongue carcinoma with clinically node-negative neck: A retrospective study of 229 cases
Feng, Zhien; Li, Jian Nan; Li, Chuan Zhen; Guo, Chuan Bin
关键词Tongue Squamous cell carcinoma Elective neck dissection Observation Prognosis
刊名JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
2014-09-01
DOI10.1016/j.jcms.2013.11.016
42期:6页:806-810
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
资助者National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; China Postdoctoral Science Foundation
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]SQUAMOUS-CELL CARCINOMA ; POSITRON-EMISSION-TOMOGRAPHY ; ORAL-CAVITY ; SUPRAOMOHYOID NECK ; CANCER ; HEAD ; METASTASIS ; BIOPSY ; MOUTH ; T1/T2
英文摘要

Background: The aim of the study is to evaluate the results of elective neck dissection (END) versus conservative management (observation) in the treatment of stages I and II squamous cell carcinoma of tongue.

Patients and methods: This is a retrospective study including 229 patients with surgical treatment between June 1993 and May 2010.

Results: There were 15 (9.6%) patients in the END group and 14(19.2%) patients in the observation group who developed nodal recurrence alone without associated local recurrence or distant metastasis. Node-related mortality rate was 5.1% (8/156) for END and 12.3% (9/73) for observation. Further analysis for subgroups of stage T1 showed that the patients from END group had a better 5-year disease-specific survival (DSS) than those from the observation group in spite of no statistical difference (87.2% vs. 76.0%, Log-rank p = 0.282). END compared with observation for patients with stage T2 had a better 5-year DSS (74.2% vs. 41.2%, Log-rank p = 0.008).

Conclusions: Elective neck dissection significantly reduces mortality due to lymph nodal metastasis and also increases the 5-year DSS, most marked in patients with stage T2 OSCC. This retrospective study suggests that END should be a preferred treatment strategy for tongue carcinoma in stage T2. (C) 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

语种英语
所属项目编号81302350 ; 2009AA045201 ; 2013M530495
资助者National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; China Postdoctoral Science Foundation
WOS记录号WOS:000341463000017
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60545
专题北京大学口腔医学院
作者单位Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Feng, Zhien,Li, Jian Nan,Li, Chuan Zhen,et al. Elective neck dissection versus observation in the management of early tongue carcinoma with clinically node-negative neck: A retrospective study of 229 cases[J]. JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY,2014,42(6):806-810.
APA Feng, Zhien,Li, Jian Nan,Li, Chuan Zhen,&Guo, Chuan Bin.(2014).Elective neck dissection versus observation in the management of early tongue carcinoma with clinically node-negative neck: A retrospective study of 229 cases.JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY,42(6),806-810.
MLA Feng, Zhien,et al."Elective neck dissection versus observation in the management of early tongue carcinoma with clinically node-negative neck: A retrospective study of 229 cases".JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY 42.6(2014):806-810.
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