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学科主题口腔医学
Aberrant expression of B-catenin, Pin1 and cylin D1 in salivary adenoid, cystic carcinoma: Relation to tumor proliferation and metastasis
Zhou, Chuan-Xiang; Gao, Yan
关键词Pin1 beta-catenin cyclin D1 immunohistochemistry Western blot RT-PCR salivary adenoid cystic carcinomas
刊名ONCOLOGY REPORTS
2006-09-01
16期:3页:505-511
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]PROLYL ISOMERASE PIN1 ; SQUAMOUS-CELL CARCINOMA ; BETA-CATENIN ; COLORECTAL-CANCER ; BREAST-CANCER ; CYCLIN D1 ; PROGNOSTIC MARKER ; SIGNALING PATHWAY ; MISMATCH REPAIR ; MUTATIONS
英文摘要

The aims of this study were to investigate the expression levels of beta-catenin, Pin1 and cyclin D1 in salivary adenoid cystic carcinomas (SACC) and to evaluate its clinical importance, furthermore, to elucidate whether B-catenin expression was aberrant in SACC and whether Pin1 was involved in aberrant beta-catenin and cyclin D1 expression. The expression of Pin 1, B-catenin and cyclin D I were examined in the specimens of 65 patients with SACC by immunohistochemistry, protein and mRNA expressions were detected by Western blotting and RT-PCR in four SACC cell lines. Pin1 was overexpressed in 51 cases of SACC (78%), and high levels of Pin1 expression correlated with cyclin D1 positive expression (p=0.02). Fourteen (22%) cases showed positive immunoreactivity for B-catenin protein in the nuclear/cytoplasmic fraction in tumor tissues, which was defined as cytoplasm/nucleus staining, among which quite evident nuclear expression of beta-catenin was detected in six cases (9%), while cyclin D1 positive expression was detected in 41 cases of SACC (63%). Reduced membranous expression of beta-catenin was detected in the cases with metastasis (11/14). Theses results suggest that Pin1 and Wnt signalling pathway are activated in SACC and may play a pivotal role in SACC carcinogenesis and metastasis.

语种英语
WOS记录号WOS:000239733300010
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被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60547
专题北京大学口腔医学院_口腔病理科
作者单位Peking Univ, Dept Oral Pathol, Sch Stomatol, Beijing, Peoples R China
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Zhou, Chuan-Xiang,Gao, Yan. Aberrant expression of B-catenin, Pin1 and cylin D1 in salivary adenoid, cystic carcinoma: Relation to tumor proliferation and metastasis[J]. ONCOLOGY REPORTS,2006,16(3):505-511.
APA Zhou, Chuan-Xiang,&Gao, Yan.(2006).Aberrant expression of B-catenin, Pin1 and cylin D1 in salivary adenoid, cystic carcinoma: Relation to tumor proliferation and metastasis.ONCOLOGY REPORTS,16(3),505-511.
MLA Zhou, Chuan-Xiang,et al."Aberrant expression of B-catenin, Pin1 and cylin D1 in salivary adenoid, cystic carcinoma: Relation to tumor proliferation and metastasis".ONCOLOGY REPORTS 16.3(2006):505-511.
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