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学科主题: 精神卫生
题名:
Cortisol and cytokines in chronic and treatment-resistant patients with schizophrenia: Association with psychopathology and response to antipsychotics
作者: Zhang, XY; Zhou, DF; Cao, LY; Wu, GY; Shen, YC
关键词: schizophrenia ; immune ; interleukin ; cortisol ; psychopathology ; antipsychotic ; hypothalamic-pituitary-adrenal (HPA) axis
刊名: NEUROPSYCHOPHARMACOLOGY
发表日期: 2005-08-01
DOI: 10.1038/sj.npp.1300756
卷: 30, 期:8, 页:1532-1538
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: PITUITARY-ADRENAL AXIS ; DEXAMETHASONE-SUPPRESSION TEST ; ATYPICAL ANTIPSYCHOTICS ; SERUM INTERLEUKIN-6 ; NEGATIVE SYMPTOMS ; PLASMA-CORTISOL ; HPA AXIS ; NEUROLEPTICS ; RISPERIDONE ; CLOZAPINE
英文摘要:

The bilateral communication between the immune and neuroendocrine systems plays an essential role in modulating the adequate response of the hypothalamic-pituitary-adrenal (HPA) axis to the stimulatory influence of cytokines and stress-related mediators. Growing evidence suggests that neuro-immune-endocrine crosstalk may be impaired in schizophrenia. We determined the relationship between cortisol, cytokines interleukin-2 (IL-2) and interleukin-6 (IL-6), and symptoms in schizophrenia during treatment with typical and atypical antipsychotic drugs. Subjects included 30 healthy controls (HC) and 78 schizophrenic (SCH) in-patients. SCH were randomly assigned to 12-week treatment with 6 mg/day of risperidone or 20 mg/day of haloperidol using a double-blind design. Clinical efficacy was determined using the Positive and Negative Syndrome Scale (PANSS). Serum cortisol and IL-2 levels were assayed by radioimmunometric assay, and serum IL-6 levels by quantitative enzyme-linked immunosorbent assay. Following a 2-week washout period, serum levels of cortisol, IL-2, and IL-6 were increased in patients with schizophrenia compared to HC. Elevations in cortisol were associated with increase in both IL-2 and IL-6 in SCH. Moreover, elevations in cortisol were associated with negative symptoms and IL-2 with positive symptoms. In all, 12 weeks of risperidone treatment significantly decreased elevated cortisol and improved negative symptoms, but produced similar effects on IL-2 and IL-6 as well as on positive symptoms compared to haloperidol. The improvement of negative symptoms was related to the change in cortisol. Our results suggest that the imbalance in the HPA axis and cytokine system in patients with SCH is implicated in clinical symptoms, and is improved with atypical antipsychotic treatment.

语种: 英语
WOS记录号: WOS:000230586900013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60550
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Beijing Hui Long Guan Hosp, Beijing, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Yale Univ, Sch Med, VA Connecticut Healthcare Syst, Dept Psychiat, West Haven, CT 06516 USA

Recommended Citation:
Zhang, XY,Zhou, DF,Cao, LY,et al. Cortisol and cytokines in chronic and treatment-resistant patients with schizophrenia: Association with psychopathology and response to antipsychotics[J]. NEUROPSYCHOPHARMACOLOGY,2005,30(8):1532-1538.
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