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学科主题基础医学
Modulation of cellular immunity by antibodies against calreticulin
Qiu, Xiang2; Hong, Chao1; Zhong, Zhaoyan2; Li, Yue2; Zhang, Tengteng1; Bao, Wanrong1; Xiong, Sidong1; Gao, Xiao-Ming1,2
关键词Anti-CRT antibodies Calreticulin Immunoregulation
刊名EUROPEAN JOURNAL OF IMMUNOLOGY
2012-09-01
DOI10.1002/eji.201142320
42期:9页:2419-2430
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]HEAT-SHOCK PROTEINS ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; ANTIGEN-PRESENTING CELLS ; SURFACE CALRETICULIN ; APOPTOTIC CELLS ; DENDRITIC CELLS ; T-CELLS ; MOLECULAR CHAPERONE ; ACTIVATION ; RECEPTOR
英文摘要

Although caltreticulin (CRT) is mainly a residential ER protein, it is also expressed on the membrane surface of various types of cells exhibiting multiple functions. We report here that intraperitoneal administration of a soluble recombinant CRT fragment (rCRT/39-272) led to a substantial decrease in delayed type hypersensitivity (DTH) responses in BALB/c mice and EAE in C57BL/6 mice. In the recall response against keyhole limpet hemocyanin (KLH) in vitro, draining lymph node cells from the rCRT/39-272-treated mice produced less IFN-? but more IL-4 as compared with the cells from the control group. The immunomodulating effect of intraperitoneally administered rCRT/39-272 was attributed to anti-CRT Abs thereby induced, because, in passive transfer experiments, the CRT-specific antiserum could suppress DTH in BALB/c mice. B-cell-deficient mu MT mice were not susceptible to rCRT/39-272-mediated DTH suppression. Furthermore, CRT appears on the surface of murine T cells soon after activation and remains detectable (at relatively low level) by flow cytometry for approximately 5 days in vitro. Anti-CRT Abs were able to inhibit AKT phosphorylation, proliferation, and cytokine production by activated murine T cells. We propose that cell surface CRT could play a role in the function of effector T cells and may be considered a target for immunological manipulation.

语种英语
WOS记录号WOS:000308404800024
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60555
专题北京大学基础医学院_免疫学系
作者单位1.Soochow Univ, Inst Biol & Med Sci, Suzhou 215123, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100871, Peoples R China
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Qiu, Xiang,Hong, Chao,Zhong, Zhaoyan,et al. Modulation of cellular immunity by antibodies against calreticulin[J]. EUROPEAN JOURNAL OF IMMUNOLOGY,2012,42(9):2419-2430.
APA Qiu, Xiang.,Hong, Chao.,Zhong, Zhaoyan.,Li, Yue.,Zhang, Tengteng.,...&Gao, Xiao-Ming.(2012).Modulation of cellular immunity by antibodies against calreticulin.EUROPEAN JOURNAL OF IMMUNOLOGY,42(9),2419-2430.
MLA Qiu, Xiang,et al."Modulation of cellular immunity by antibodies against calreticulin".EUROPEAN JOURNAL OF IMMUNOLOGY 42.9(2012):2419-2430.
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