北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Search for genetic determinants of sulfonylurea efficacy in type 2 diabetic patients from China
作者: Ren, Qian1; Han, Xueyao1; Tang, Yong2; Zhang, Xiuying1; Zou, Xiantong1; Cai, Xiaoling1; Zhang, Simin1; Zhang, Lihua1; Li, Hechao1; Ji, Linong1
关键词: Glibenclamide ; Pharmacogenetics ; SNP ; Type 2 diabetes
刊名: DIABETOLOGIA
发表日期: 2014-04-01
DOI: 10.1007/s00125-013-3146-z
卷: 57, 期:4, 页:746-753
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: GENOME-WIDE ASSOCIATION ; THERAPEUTIC RESPONSE ; INSULIN-RESISTANCE ; SECONDARY FAILURE ; ALLELIC VARIANTS ; FASTING GLUCOSE ; COMMON VARIANTS ; INCREASED RISK ; E23K VARIANT ; CYP2C9
英文摘要:

Aims/hypothesis The aim of this study was to investigate whether genetic variance can influence the efficacy of glibenclamide in patients with type 2 diabetes.

A total of 747 patients with type 2 diabetes was enrolled from the Xiaoke Pills Clinical Trial, which is a double-blind, randomised controlled trial. All the patients had been treated with glibenclamide for 48 weeks, with strict drug dose adjustment and data collection. Treatment failure was confirmed when patients reached the criteria for terminating their participation in the study (fasting blood glucose level a parts per thousand yen7.0 mmol/l on two consecutive tests 4 weeks after reaching the pre-set maximal dose or maximal tolerated dose). Using this cohort, we tested 44 single-nucleotide polymorphisms (SNPs) in 27 gene regions. The genes in our study were involved in the metabolism of sulfonylureas, islet beta cell function, insulin resistance and beta cell growth and differentiation. A logistic regression model was used to evaluate the relationship between genetic variants and treatment failure over a period of 48 weeks.

We found that no SNP reached the significance level of p < 0.00125 if Bonferroni correction was performed for multiple testing in the logistic regression model used in this pharmacogenetic study. Participants with the minor allele C of rs10811661 in CDKN2A/CDKN2B showed a significantly greater reduction in fasting blood glucose (TT vs TC vs CC: 9.3% (0-20.0%) vs 9.2% (0.9-20.5%) vs 12.7% (5.2-24.4%), p = 0.008) after the initial 4 weeks of treatment independent of age, sex and BMI. There was a significant difference in beta cell function among carriers of different genotypes of rs10811661.

Our study demonstrated that the CDKN2A/CDKN2B gene may be nominally associated with the efficacy of glibenclamide, and that CDKN2A/CDKN2B is associated with beta cell function.

语种: 英语
所属项目编号: 2012AA02A509 ; 2006AA02A409 ; 81000334 ; 2006CB503903
项目资助者: National High Technology Research and Development Program 863 program ; Guangzhou Zhongyi Pharmaceutical ; National Natural Science Fund ; National Basic Research Program of China 973 program
WOS记录号: WOS:000332600700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60556
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Hebei Peoples Hosp, Dept Endocrinol & Metab, Hebei, Peoples R China
2.Peking Univ, Dept Endocrinol & Metab, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Ren, Qian,Han, Xueyao,Tang, Yong,et al. Search for genetic determinants of sulfonylurea efficacy in type 2 diabetic patients from China[J]. DIABETOLOGIA,2014,57(4):746-753.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ren, Qian]'s Articles
[Han, Xueyao]'s Articles
[Tang, Yong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ren, Qian]‘s Articles
[Han, Xueyao]‘s Articles
[Tang, Yong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace