IR@PKUHSC  > 北京大学第三临床医学院  > 眼科
学科主题临床医学
Microglial activation in human diabetic retinopathy
Zeng, Hui-yang1,2; Green, William Richard1; Tso, Mark O. M.1,2
刊名ARCHIVES OF OPHTHALMOLOGY
2008-02-01
126期:2页:227-232
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; RETINA ; MECHANISMS ; EXPRESSION ; CYTOKINES ; ISCHEMIA ; MARKERS ; INJURY
英文摘要

Objective: To investigate microglial activation in human diabetic retinopathy.

Methods: Paraffin sections from 21 eyes of 13 patients with diabetic background, preproliferative, or proliferative retinopathies and 10 normal eyes of 9 individuals were studied with immunolabeling of microglia with antibodies against HLA-DR antigen, CD45, or CD68.

Results: In the healthy human eyes, ramified microglial cells were scattered in the inner retinal layers. In eyes with diabetic retinopathy, the microglia were markedly increased in number and were hypertrophic at different stages of the disease. These cells clustered around the retinal vasculature, especially the dilated veins, microaneurysms, intraretinal hemorrhages, cotton-wool spots, optic nerve, and retinal and vitreal neovascularization. In some retinas with cystoid macular edema, microglia infiltrated the outer retina and subretinal space. Cells in the epiretinal membrane were also labeled with microglial markers.

Conclusions: Microglia were activated at different stages of human diabetic retinopathy and optic neuropathy. Microglial perivasculitis was a prominent feature of the disease process.

Clinical Relevance: Activated microglia and microglial perivasculitis may play a role in vasculopathy and neuropathy in diabetic retinopathy.

语种英语
WOS记录号WOS:000253059700010
Citation statistics
Cited Times:124[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60558
Collection北京大学第三临床医学院_眼科
作者单位1.Johns Hopkins Univ Hosp, Wilmer Eye Inst, Baltimore, MD 21287 USA
2.Peking Univ, Ctr Eye, Peking Univ Third Hosp, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zeng, Hui-yang,Green, William Richard,Tso, Mark O. M.. Microglial activation in human diabetic retinopathy[J]. ARCHIVES OF OPHTHALMOLOGY,2008,126(2):227-232.
APA Zeng, Hui-yang,Green, William Richard,&Tso, Mark O. M..(2008).Microglial activation in human diabetic retinopathy.ARCHIVES OF OPHTHALMOLOGY,126(2),227-232.
MLA Zeng, Hui-yang,et al."Microglial activation in human diabetic retinopathy".ARCHIVES OF OPHTHALMOLOGY 126.2(2008):227-232.
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