北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 眼科  > 期刊论文
学科主题: 临床医学
题名:
Microglial activation in human diabetic retinopathy
作者: Zeng, Hui-yang1,2; Green, William Richard1; Tso, Mark O. M.1,2
刊名: ARCHIVES OF OPHTHALMOLOGY
发表日期: 2008-02-01
卷: 126, 期:2, 页:227-232
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; RETINA ; MECHANISMS ; EXPRESSION ; CYTOKINES ; ISCHEMIA ; MARKERS ; INJURY
英文摘要:

Objective: To investigate microglial activation in human diabetic retinopathy.

Methods: Paraffin sections from 21 eyes of 13 patients with diabetic background, preproliferative, or proliferative retinopathies and 10 normal eyes of 9 individuals were studied with immunolabeling of microglia with antibodies against HLA-DR antigen, CD45, or CD68.

Results: In the healthy human eyes, ramified microglial cells were scattered in the inner retinal layers. In eyes with diabetic retinopathy, the microglia were markedly increased in number and were hypertrophic at different stages of the disease. These cells clustered around the retinal vasculature, especially the dilated veins, microaneurysms, intraretinal hemorrhages, cotton-wool spots, optic nerve, and retinal and vitreal neovascularization. In some retinas with cystoid macular edema, microglia infiltrated the outer retina and subretinal space. Cells in the epiretinal membrane were also labeled with microglial markers.

Conclusions: Microglia were activated at different stages of human diabetic retinopathy and optic neuropathy. Microglial perivasculitis was a prominent feature of the disease process.

Clinical Relevance: Activated microglia and microglial perivasculitis may play a role in vasculopathy and neuropathy in diabetic retinopathy.

语种: 英语
WOS记录号: WOS:000253059700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60558
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Johns Hopkins Univ Hosp, Wilmer Eye Inst, Baltimore, MD 21287 USA
2.Peking Univ, Ctr Eye, Peking Univ Third Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Zeng, Hui-yang,Green, William Richard,Tso, Mark O. M.. Microglial activation in human diabetic retinopathy[J]. ARCHIVES OF OPHTHALMOLOGY,2008,126(2):227-232.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zeng, Hui-yang]'s Articles
[Green, William Richard]'s Articles
[Tso, Mark O. M.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zeng, Hui-yang]‘s Articles
[Green, William Richard]‘s Articles
[Tso, Mark O. M.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace