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IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学肝病研究所  > 期刊论文
学科主题: 临床医学
题名:
Features of hepatitis C virus infection, current therapies and ongoing clinical trials in ten Asian Pacific countries
作者: Omata, Masao1,2; Kanda, Tatsuo3; Yokosuka, Osamu3; Crawford, Darrell4; Al-Mahtab, Mamun5; Wei, Lai6; Ibrahim, Alaaeldin7; Lau, George K. K.8,9; Sharma, Barjesh C.10; Hamid, Saeed S.11; Chuang, Wan-Long12; Dokmeci, A. Kadir13
关键词: Asian Pacific countries ; HCV ; IL28B ; Direct-acting antivirals
刊名: HEPATOLOGY INTERNATIONAL
发表日期: 2015-10-01
DOI: 10.1007/s12072-015-9630-4
卷: 9, 期:4, 页:486-507
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: SUSTAINED VIROLOGICAL RESPONSE ; RANDOMIZED CONTROLLED-TRIAL ; HEALTH-CARE WORKERS ; INTERFERON-ALPHA-2B PLUS RIBAVIRIN ; CHRONIC LIVER-DISEASES ; CHRONIC-RENAL-FAILURE ; LONG-TERM EFFICACY ; CHRONIC GENOTYPE 2 ; BLOOD-DONORS ; RISK-FACTORS
英文摘要:

Estimated hepatitis C virus (HCV) infection rates in the general populations were 1.3, 0.9, 0.4-1.0, 14.7, 0.1-0.3, 0.9-1.9, 1.0-2.0, 5, 4.4-8.6 and 0.5-1.3 % in Australia, Bangladesh, Mainland China, Egypt, Hong Kong, India, Japan, Pakistan, Taiwan and Turkey, respectively. The main HCV genotypes (Gs) are G1, G3, G1b, G4, G1b, G3, G1b, G3, G1b and G2, and G1 in Australia, Bangladesh, Mainland China, Egypt, Hong Kong, India, Japan, Pakistan, Taiwan and Turkey, respectively. Of IL28B genotypes, favorable alleles are similar to 50 % in Australia and Turkey, but 60-70 % in most of the other Asian countries. Peginterferon plus ribavirin is available in all ten Asian Pasific countries. In addition, HCV NS3/4A protease inhibitors with peginterferon plus ribavirin are currently available in several countries. Clinical trials of interferon-free regimens for HCV are ongoing in most of the ten Asian Pacific countries.

语种: 英语
项目资助者: Chugai Pharmaceutical ; MSD ; Sumitomo Dainippon Pharma ; Tanabe-Mitsubishi ; Ajinomoto ; Bristol-Myers Squibb ; Daiichi-Sankyo ; Janssen Pharmaceutical ; Bayer ; Abbvie ; Gilead ; GlaxoSmithKline
WOS记录号: WOS:000363044000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60559
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.Yamanashi Hosp Cent & Kita Org, Kofu, Yamanashi 4008506, Japan
2.Univ Tokyo, Bunkyo Ku, Tokyo 1138655, Japan
3.Chiba Univ, Grad Sch Med, Dept Gastroenterol & Nephrol, Chuo Ku, Chiba 2608677, Japan
4.Univ Queensland, Sch Med, Woolloongabba, Qld 4102, Australia
5.Bangabandhu Sheikh Mujib Med Univ, Dept Hepatol, Dhaka 1000, Bangladesh
6.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100871, Peoples R China
7.Benha Univ, Dept Internal Med, GI Liver Div, Banha, Egypt
8.302 Hosp, Hong Kong SAR China Inst Translat Hepatol, Humanity & Hlth Med Ctr, Beijing, Peoples R China
9.302 Hosp, Ctr Liver Fibrosis Diag & Treatment Ctr, Beijing, Peoples R China
10.GB Pant Hosp, Dept Gastroenterol, New Delhi, India
11.Aga Khan Univ & Hosp, Dept Med, Karachi 74800, Pakistan
12.Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Hepatobiliary Div, Dept Internal Med, Kaohsiung, Taiwan
13.Ankara Univ, Sch Med, Dept Gastroenterol, TR-06100 Ankara, Turkey

Recommended Citation:
Omata, Masao,Kanda, Tatsuo,Yokosuka, Osamu,et al. Features of hepatitis C virus infection, current therapies and ongoing clinical trials in ten Asian Pacific countries[J]. HEPATOLOGY INTERNATIONAL,2015,9(4):486-507.
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