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Interactions Between MAOA and SYP Polymorphisms were Associated with Symptoms of Attention-Deficit/Hyperactivity Disorder in Chinese Han Subjects
Gao, Qian1,2; Liu, Lu1,2; Li, Hai-Mei1,2; Tang, Yi-Lang3; Wu, Zhao-Min1,2; Chen, Yun1,2; Wang, Yu-Feng1,2; Qian, Qiu-Jin1,2
关键词ADHD MAOA SYP gene interaction
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2015
DOI10.1002/ajmg.b.32273
168期:1页:45-53
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
资助者National Basic Research Development Program of China ; National Natural Sciences Foundation of China ; Program for New Century Excellent Talents in University ; National Basic Research Development Program of China ; National Natural Sciences Foundation of China ; Program for New Century Excellent Talents in University
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]DEFICIT HYPERACTIVITY DISORDER ; MONOAMINE-OXIDASE-A ; GENOME-WIDE ASSOCIATION ; DETECTING GENE-GENE ; MULTIFACTOR DIMENSIONALITY REDUCTION ; PREFERENTIAL TRANSMISSION ; ENVIRONMENT INTERACTIONS ; COMBINATORIAL APPROACH ; INATTENTIVE SUBTYPE ; MOLECULAR-GENETICS
英文摘要

As candidate genes of attention-deficit/hyperactivity disorder (ADHD), monoamine oxidase A (MAOA), and synaptophysin (SYP) are both on theXchromosome, and have been suggested to be associated with the predominantly inattentive subtype (ADHD-I). The present study is to investigate the potential gene-gene interaction (G x G) between rs5905859 of MAOA and rs5906754 of SYP for ADHD in Chinese Han subjects. For family-based association study, 177 female trios were included. For case-control study, 1,462 probands and 807 normal controls were recruited. TheADHDRating Scale-IV(ADHD-RSIV) was used to evaluate ADHD symptoms. Pedigree-based generalized multifactor dimensionality reduction (PGMDR) for female ADHD trios indicated significant gene interaction effect of rs5905859 and rs5906754. Generalized multifactor dimensionality reduction (GMDR) indicated potential gene-gene interplay on ADHD RS-IV scores in female ADHD-I. No associations were observed in male subjects in case-control analysis. In conclusion, our findings suggested that the interaction of MAOA and SYP may be involved in the genetic mechanism of ADHD-I subtype and predict ADHD symptoms. (C) 2014 Wiley Periodicals, Inc.

语种英语
所属项目编号973 program 2014CB846104 ; 81071109 ; 81301171 ; NCET-11-0013
资助者National Basic Research Development Program of China ; National Natural Sciences Foundation of China ; Program for New Century Excellent Talents in University ; National Basic Research Development Program of China ; National Natural Sciences Foundation of China ; Program for New Century Excellent Talents in University
WOS记录号WOS:000350064100004
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60565
专题北京大学精神卫生研究所
作者单位1.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA
2.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
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GB/T 7714
Gao, Qian,Liu, Lu,Li, Hai-Mei,et al. Interactions Between MAOA and SYP Polymorphisms were Associated with Symptoms of Attention-Deficit/Hyperactivity Disorder in Chinese Han Subjects[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2015,168(1):45-53.
APA Gao, Qian.,Liu, Lu.,Li, Hai-Mei.,Tang, Yi-Lang.,Wu, Zhao-Min.,...&Qian, Qiu-Jin.(2015).Interactions Between MAOA and SYP Polymorphisms were Associated with Symptoms of Attention-Deficit/Hyperactivity Disorder in Chinese Han Subjects.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,168(1),45-53.
MLA Gao, Qian,et al."Interactions Between MAOA and SYP Polymorphisms were Associated with Symptoms of Attention-Deficit/Hyperactivity Disorder in Chinese Han Subjects".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 168.1(2015):45-53.
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