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学科主题基础医学
Arcuate nucleus of hypothalamus is involved in mediating the satiety effect of electroacupuncture in obese rats
Wang, Fei2,3,4; Tian, De Run1,2; Tso, Patrick3,4; Han, Ji Sheng2
关键词Diet-induced obesity Electroacupuncture Arcuate nucleus of hypothalamus POMC alpha-MSH
刊名PEPTIDES
2011-12-01
DOI10.1016/j.peptides.2011.10.019
32期:12页:2394-2399
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]FEEDING-BEHAVIOR ; FOOD-INTAKE ; EXPRESSION ; PEPTIDE ; NEURONS ; BRAIN ; WOMEN ; CART ; MELANOCORTIN ; ACUPUNCTURE
英文摘要

Obesity is a major health problem in the world. Since effective remedies are rare, researchers are trying to discover new therapies for obesity, and acupuncture is among the most popular alternative approaches. This study investigated the anti-obesity mechanisms of EA, using a rat model of diet-induced obesity. After feeding with a high-fat diet for 9 weeks, a number of rats who gained weight that surpassed the maximal body weight of rats in the chow-fed group were considered obese and employed in the study. A 2 Hz EA treatment at the acupoints ST36/SP6 with the intensity increasing stepwise from 0.5-1-1.5 mA was given once a day for 30 min. Rats treated with EA showed significantly decreased food intake and reduced body weight compared with the rats in DIO and restraint group. EA treatment increased peptide levels of alpha-MSH and mRNA levels of its precursor POMC in the arcuate nuclear of hypothalamus (ARH) neurons. In addition, the cerebral spinal fluid (CSF) content of alpha-MSH was elevated by EA application. ARH lesions by monosodium glutamate abolished the inhibition effect of EA on food intake and body weight. A non-acupoint stimulation did not show the benefit effect on food intake inhibition and body weight reduction compared with restraint and ST36/SP6 EA treatment. We concluded that EA treatment at ST36/SP6 acted through ARH to significantly inhibit food intake and body weight gain when fed a high-fat diet and that the stimulation of alpha-MSH expression and release might be involved in the mechanism. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000299194000003
项目编号07JCZDJC08100 ; 30870791 ; 985
资助机构Natural Science Foundation of Tianjin ; National Natural Science Foundation of China ; Ministry of Education
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60566
专题北京大学基础医学院_神经生物学系
作者单位1.Univ Cincinnati, Dept Pathol & Lab Med, Cincinnati, OH USA
2.Univ Cincinnati, Dept Psychiat, Cincinnati, OH USA
3.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
4.Tianjin Med Univ, Dept Anat, Tianjin 300070, Peoples R China
推荐引用方式
GB/T 7714
Wang, Fei,Tian, De Run,Tso, Patrick,et al. Arcuate nucleus of hypothalamus is involved in mediating the satiety effect of electroacupuncture in obese rats[J]. PEPTIDES,2011,32(12):2394-2399.
APA Wang, Fei,Tian, De Run,Tso, Patrick,&Han, Ji Sheng.(2011).Arcuate nucleus of hypothalamus is involved in mediating the satiety effect of electroacupuncture in obese rats.PEPTIDES,32(12),2394-2399.
MLA Wang, Fei,et al."Arcuate nucleus of hypothalamus is involved in mediating the satiety effect of electroacupuncture in obese rats".PEPTIDES 32.12(2011):2394-2399.
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