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学科主题: 基础医学
题名:
Arcuate nucleus of hypothalamus is involved in mediating the satiety effect of electroacupuncture in obese rats
作者: Wang, Fei2,3,4; Tian, De Run1,2; Tso, Patrick3,4; Han, Ji Sheng2
关键词: Diet-induced obesity ; Electroacupuncture ; Arcuate nucleus of hypothalamus ; POMC ; alpha-MSH
刊名: PEPTIDES
发表日期: 2011-12-01
DOI: 10.1016/j.peptides.2011.10.019
卷: 32, 期:12, 页:2394-2399
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: FEEDING-BEHAVIOR ; FOOD-INTAKE ; EXPRESSION ; PEPTIDE ; NEURONS ; BRAIN ; WOMEN ; CART ; MELANOCORTIN ; ACUPUNCTURE
英文摘要:

Obesity is a major health problem in the world. Since effective remedies are rare, researchers are trying to discover new therapies for obesity, and acupuncture is among the most popular alternative approaches. This study investigated the anti-obesity mechanisms of EA, using a rat model of diet-induced obesity. After feeding with a high-fat diet for 9 weeks, a number of rats who gained weight that surpassed the maximal body weight of rats in the chow-fed group were considered obese and employed in the study. A 2 Hz EA treatment at the acupoints ST36/SP6 with the intensity increasing stepwise from 0.5-1-1.5 mA was given once a day for 30 min. Rats treated with EA showed significantly decreased food intake and reduced body weight compared with the rats in DIO and restraint group. EA treatment increased peptide levels of alpha-MSH and mRNA levels of its precursor POMC in the arcuate nuclear of hypothalamus (ARH) neurons. In addition, the cerebral spinal fluid (CSF) content of alpha-MSH was elevated by EA application. ARH lesions by monosodium glutamate abolished the inhibition effect of EA on food intake and body weight. A non-acupoint stimulation did not show the benefit effect on food intake inhibition and body weight reduction compared with restraint and ST36/SP6 EA treatment. We concluded that EA treatment at ST36/SP6 acted through ARH to significantly inhibit food intake and body weight gain when fed a high-fat diet and that the stimulation of alpha-MSH expression and release might be involved in the mechanism. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 07JCZDJC08100 ; 30870791 ; 985
项目资助者: Natural Science Foundation of Tianjin ; National Natural Science Foundation of China ; Ministry of Education
WOS记录号: WOS:000299194000003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60566
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Univ Cincinnati, Dept Pathol & Lab Med, Cincinnati, OH USA
2.Univ Cincinnati, Dept Psychiat, Cincinnati, OH USA
3.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
4.Tianjin Med Univ, Dept Anat, Tianjin 300070, Peoples R China

Recommended Citation:
Wang, Fei,Tian, De Run,Tso, Patrick,et al. Arcuate nucleus of hypothalamus is involved in mediating the satiety effect of electroacupuncture in obese rats[J]. PEPTIDES,2011,32(12):2394-2399.
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