北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
The Role of Anti-Mutated Citrullinated Vimentin Antibodies in the Diagnosis of Early Rheumatoid Arthritis
作者: Liu, Xia; Jia, Rulin; Zhao, Jinxia; Li, Zhanguo
关键词: ANTI-MUTATED CITRULLINATED VIMENTIN ; DIAGNOSIS ; EARLY RHEUMATOID ARTHRITIS
刊名: JOURNAL OF RHEUMATOLOGY
发表日期: 2009-06-01
DOI: 10.3899/jrheum.080796
卷: 36, 期:6, 页:1136-1142
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: ANTIGENIC DETERMINANTS ; REVISED CRITERIA ; AUTOANTIBODIES ; CLASSIFICATION ; DISEASE ; MACROPHAGES ; PROTEINS
英文摘要:

Objective. Anti-mutated citrullinated vimentin (MCV) antibodies have been reported as a fairly sensitive serological marker of rheumatoid arthritis (RA). We evaluated the diagnostic value of anti-MCV in a large cohort of Chinese patients with early RA.

Methods. One hundred seventy patients with early RA (< 1 yr duration), 66 with other rheumatic diseases, 10 with infectious diseases, and 60 healthy individuals were included in our study. Serum anti-MCV and second-generation anti-cyclic citrullinated peptide antibodies (anti-CCP2) were measured by ELISA, and rheumatoid factor (RF) was measured by rate nephelometry. The associated clinical data of patients with early RA were also evaluated. Then disease activity was scored by the formula for Disease Activity Score (DAS)28, and the degree of radiological changes was assessed by Sharp score.

Results. The prevalence of serum anti-MCV in patients with early RA (78.2%, 133/170) was significantly higher than that of other rheumatologic patients and patients with infectious diseases. It was 12% (3/25) in systemic lupus erythematosus, 9.5% (2/21) in primary Sjogren′s syndrome, 10% (1/10) in systemic sclerosis, 20% (2/10) in ankylosing spondylitis, 12.5% (1/8) in viral hepatitis type B, and 0% (0/2) in tuberculosis. Anti-MCV was not found in the serum of healthy subjects. The sensitivities of anti-MCV, anti-CCP2, and RF tests for early RA were 78.2%, 61.8%, and 72.4%, respectively, and the specificities were 93.4%, 96.3%, and 80.1%. The combination of anti-MCV and anti-CCP2 positivity showed a very high specificity (97.8%) and positive predictive value (97.1%), anti but a low sensitivity (58.8%). The sensitivity reached 81.2% when the union of anti-MCV and anti-CCP2 positivities was used as one combined criterion. Statistically, anti-MCV had significant correlation with anti-CCP2 (r = 0.587, p = 0.01, 2-tailed) and RF (r = 0.389, p = 0.01, 2-tailed). In addition. it had an interesting correlation with radiological assessment (r = 0.349 p = 0.05, 2-tailed). The anti-MCV had no significant correlation with other factors, such as erythrocyte sedimentation rate, C-reactive protein, antikeratin antibody, antiperinuclear factor, global visual analog scale score for joint pain, IgA, IgG, 1(,M, C3, C4, hidden rheumatoid factor for IgA (HRFIA), HRFIgG, and DAS28.

Conclusion. Anti-MCV is a novel diagnostic marker for early RA. It may be more useful if the anti-CCP2 assay is performed concomitantly to diagnose patients with early RA. (First Release May 15 2009: J Rheumatol 2009;36:1136-42; doi: 10.3899/jrhewn.080796)

语种: 英语
WOS记录号: WOS:000266891500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60567
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Xia,Jia, Rulin,Zhao, Jinxia,et al. The Role of Anti-Mutated Citrullinated Vimentin Antibodies in the Diagnosis of Early Rheumatoid Arthritis[J]. JOURNAL OF RHEUMATOLOGY,2009,36(6):1136-1142.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Xia]'s Articles
[Jia, Rulin]'s Articles
[Zhao, Jinxia]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Xia]‘s Articles
[Jia, Rulin]‘s Articles
[Zhao, Jinxia]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace