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The Role of Anti-Mutated Citrullinated Vimentin Antibodies in the Diagnosis of Early Rheumatoid Arthritis
Liu, Xia; Jia, Rulin; Zhao, Jinxia; Li, Zhanguo
关键词ANTI-MUTATED CITRULLINATED VIMENTIN DIAGNOSIS EARLY RHEUMATOID ARTHRITIS
刊名JOURNAL OF RHEUMATOLOGY
2009-06-01
DOI10.3899/jrheum.080796
36期:6页:1136-1142
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]ANTIGENIC DETERMINANTS ; REVISED CRITERIA ; AUTOANTIBODIES ; CLASSIFICATION ; DISEASE ; MACROPHAGES ; PROTEINS
英文摘要

Objective. Anti-mutated citrullinated vimentin (MCV) antibodies have been reported as a fairly sensitive serological marker of rheumatoid arthritis (RA). We evaluated the diagnostic value of anti-MCV in a large cohort of Chinese patients with early RA.

Methods. One hundred seventy patients with early RA (< 1 yr duration), 66 with other rheumatic diseases, 10 with infectious diseases, and 60 healthy individuals were included in our study. Serum anti-MCV and second-generation anti-cyclic citrullinated peptide antibodies (anti-CCP2) were measured by ELISA, and rheumatoid factor (RF) was measured by rate nephelometry. The associated clinical data of patients with early RA were also evaluated. Then disease activity was scored by the formula for Disease Activity Score (DAS)28, and the degree of radiological changes was assessed by Sharp score.

Results. The prevalence of serum anti-MCV in patients with early RA (78.2%, 133/170) was significantly higher than that of other rheumatologic patients and patients with infectious diseases. It was 12% (3/25) in systemic lupus erythematosus, 9.5% (2/21) in primary Sjogren′s syndrome, 10% (1/10) in systemic sclerosis, 20% (2/10) in ankylosing spondylitis, 12.5% (1/8) in viral hepatitis type B, and 0% (0/2) in tuberculosis. Anti-MCV was not found in the serum of healthy subjects. The sensitivities of anti-MCV, anti-CCP2, and RF tests for early RA were 78.2%, 61.8%, and 72.4%, respectively, and the specificities were 93.4%, 96.3%, and 80.1%. The combination of anti-MCV and anti-CCP2 positivity showed a very high specificity (97.8%) and positive predictive value (97.1%), anti but a low sensitivity (58.8%). The sensitivity reached 81.2% when the union of anti-MCV and anti-CCP2 positivities was used as one combined criterion. Statistically, anti-MCV had significant correlation with anti-CCP2 (r = 0.587, p = 0.01, 2-tailed) and RF (r = 0.389, p = 0.01, 2-tailed). In addition. it had an interesting correlation with radiological assessment (r = 0.349 p = 0.05, 2-tailed). The anti-MCV had no significant correlation with other factors, such as erythrocyte sedimentation rate, C-reactive protein, antikeratin antibody, antiperinuclear factor, global visual analog scale score for joint pain, IgA, IgG, 1(,M, C3, C4, hidden rheumatoid factor for IgA (HRFIA), HRFIgG, and DAS28.

Conclusion. Anti-MCV is a novel diagnostic marker for early RA. It may be more useful if the anti-CCP2 assay is performed concomitantly to diagnose patients with early RA. (First Release May 15 2009: J Rheumatol 2009;36:1136-42; doi: 10.3899/jrhewn.080796)

语种英语
WOS记录号WOS:000266891500011
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60567
专题北京大学第二临床医学院
北京大学第二临床医学院_风湿免疫科
北京大学第三临床医学院_风湿免疫科
作者单位Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Liu, Xia,Jia, Rulin,Zhao, Jinxia,et al. The Role of Anti-Mutated Citrullinated Vimentin Antibodies in the Diagnosis of Early Rheumatoid Arthritis[J]. JOURNAL OF RHEUMATOLOGY,2009,36(6):1136-1142.
APA Liu, Xia,Jia, Rulin,Zhao, Jinxia,&Li, Zhanguo.(2009).The Role of Anti-Mutated Citrullinated Vimentin Antibodies in the Diagnosis of Early Rheumatoid Arthritis.JOURNAL OF RHEUMATOLOGY,36(6),1136-1142.
MLA Liu, Xia,et al."The Role of Anti-Mutated Citrullinated Vimentin Antibodies in the Diagnosis of Early Rheumatoid Arthritis".JOURNAL OF RHEUMATOLOGY 36.6(2009):1136-1142.
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