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学科主题临床医学
Spectrum of epileptic syndromes with electrical status epilepticus during sleep in children
Liu, XY; Wong, V
刊名PEDIATRIC NEUROLOGY
2000-05-01
22期:5页:371-379
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Pediatrics
研究领域[WOS]Neurosciences & Neurology ; Pediatrics
关键词[WOS]LANDAU-KLEFFNER SYNDROME ; ACQUIRED APHASIA ; FOLLOW-UP ; CLOBAZAM ; REGRESSION ; DISORDERS ; SEIZURES ; ABSENCE ; SPIKES ; WAVES
英文摘要

There has been much debate about the nosologic forms of electrical status epilepticus during sleep (ESES) that can occur in a number of syndromes. The pathogenesis of ESES is unknown, and the natural course is variable. It is debatable whether these age-specific epileptic syndromes belong to the same spectrum of disorders with different severity but a common denominator of sleep-related hypersynchronization of generalized paroxysmal epileptic discharges. This report describes 18 children with medically refractory seizures, gradual deterioration in language skills, fine-motor incoordination, behavioral changes, psychologic and intellectual regression of different degrees, and the ESES phenomenon. Most exhibited clinical and electroencephalographic responses to intravenous or oral benzodiazepines, especially if initiated within the first 2 years of seizure onset. Seizure remission was nearly complete with cessation of seizures and marked improvement in language and fine-motor skills, behavior, and intellectual function in those with an idiopathic etiology, Therapeutic trials with benzodiazepines should be given to all children with the ESES phenomenon. Sleep electroencephalographic monitoring is recommended in all young children with epilepsy and language or psychologic deterioration so that the brain dysfunction can be reversed at a critical and vulnerable period of early life. (C) 2000 by Elsevier Science Inc, All rights reserved.

语种英语
WOS记录号WOS:000088193600005
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60569
专题北京大学第一临床医学院_儿科
作者单位1.Beijing Med Univ, Teaching Hosp 1, Dept Pediat, Div Child Neurol, Beijing 100083, Peoples R China
2.Univ Hong Kong, Dept Paediat, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Liu, XY,Wong, V. Spectrum of epileptic syndromes with electrical status epilepticus during sleep in children[J]. PEDIATRIC NEUROLOGY,2000,22(5):371-379.
APA Liu, XY,&Wong, V.(2000).Spectrum of epileptic syndromes with electrical status epilepticus during sleep in children.PEDIATRIC NEUROLOGY,22(5),371-379.
MLA Liu, XY,et al."Spectrum of epileptic syndromes with electrical status epilepticus during sleep in children".PEDIATRIC NEUROLOGY 22.5(2000):371-379.
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