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学科主题: 临床医学
题名:
Spectrum of epileptic syndromes with electrical status epilepticus during sleep in children
作者: Liu, XY; Wong, V
刊名: PEDIATRIC NEUROLOGY
发表日期: 2000-05-01
卷: 22, 期:5, 页:371-379
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Pediatrics
研究领域[WOS]: Neurosciences & Neurology ; Pediatrics
关键词[WOS]: LANDAU-KLEFFNER SYNDROME ; ACQUIRED APHASIA ; FOLLOW-UP ; CLOBAZAM ; REGRESSION ; DISORDERS ; SEIZURES ; ABSENCE ; SPIKES ; WAVES
英文摘要:

There has been much debate about the nosologic forms of electrical status epilepticus during sleep (ESES) that can occur in a number of syndromes. The pathogenesis of ESES is unknown, and the natural course is variable. It is debatable whether these age-specific epileptic syndromes belong to the same spectrum of disorders with different severity but a common denominator of sleep-related hypersynchronization of generalized paroxysmal epileptic discharges. This report describes 18 children with medically refractory seizures, gradual deterioration in language skills, fine-motor incoordination, behavioral changes, psychologic and intellectual regression of different degrees, and the ESES phenomenon. Most exhibited clinical and electroencephalographic responses to intravenous or oral benzodiazepines, especially if initiated within the first 2 years of seizure onset. Seizure remission was nearly complete with cessation of seizures and marked improvement in language and fine-motor skills, behavior, and intellectual function in those with an idiopathic etiology, Therapeutic trials with benzodiazepines should be given to all children with the ESES phenomenon. Sleep electroencephalographic monitoring is recommended in all young children with epilepsy and language or psychologic deterioration so that the brain dysfunction can be reversed at a critical and vulnerable period of early life. (C) 2000 by Elsevier Science Inc, All rights reserved.

语种: 英语
WOS记录号: WOS:000088193600005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60569
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Beijing Med Univ, Teaching Hosp 1, Dept Pediat, Div Child Neurol, Beijing 100083, Peoples R China
2.Univ Hong Kong, Dept Paediat, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Liu, XY,Wong, V. Spectrum of epileptic syndromes with electrical status epilepticus during sleep in children[J]. PEDIATRIC NEUROLOGY,2000,22(5):371-379.
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