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学科主题: 临床医学
题名:
The Immunopathological Spectrum of Crescentic Glomerulonephritis: A Survey of 106 Patients in a Single Chinese Center
作者: Lin, Wei; Chen, Min; Cui, Zhao; Zhao, Ming-Hui
关键词: Crescentic glomerulonephritis ; Antineutrophil cytoplasmic antibodies ; Anti-glomerular basement membrane ; Immunofluorescence
刊名: NEPHRON CLINICAL PRACTICE
发表日期: 2010
DOI: 10.1159/000314665
卷: 116, 期:1, 页:C65-C74
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: BASEMENT-MEMBRANE DISEASE ; ANTI-GBM ANTIBODIES ; PATHOLOGICAL CHARACTERISTICS ; IMMUNE DEPOSITS ; ANCA ; VASCULITIS ; MYELOPEROXIDASE ; KIDNEY ; NEPHROPATHY
英文摘要:

Background: Crescentic glomerulonephritis (CrGN) is a severe form of glomerular injury. We retrospectively analyzed data from Chinese patients with CrGN in our center to characterize the immunopathological spectrum of CrGN. Methods: A total of 106 consecutive patients with biopsy-proven CrGN were recruited. CrGN was classified into 3 types according to findings on immunofluorescence microscopy; type I was defined as a linear deposition of immunoglobulins along the glomerular basement membrane (GBM), type II as a glomerular deposition of immune-complex and type III as a pauci-immune deposition. Results: A total of 17/106 (16.0%) patients were classified as type I, 43/106 (40.6%) as type II and 46/106 (43.4%) as type III. Serum antineutrophil cytoplasmic antibodies (ANCA) could be detected in 1/17 (5.9%) patient with type I, 11/43 (25.6%) patients with type II and 29/46 (63.0%) patients with type III CrGN (p < 0.001). Serum anti-GBM antibodies could be detected in 14/17 (82.4%) patients with type I, 2/43 (4.7%) patients with type II and 3/46 (6.5%) patients with type III. In type II CrGN, ANCA-positive patients were older (p < 0.001), had more multi-system involvement (p < 0.001) and more fibrinoid necrosis in renal histopathology than ANCA-negative patients (p = 0.003). Conclusions: Pauci-immune CrGN might be the most common type of CrGN in Northern China. There was much heterogeneity within each type of CrGN. Copyright (C) 2010 S. Karger AG, Basel

语种: 英语
所属项目编号: 30725034 ; 30972733 ; 985-2-104-113
项目资助者: National Science Fund for Distinguished Young Scholars ; National Natural Science Fund ; Chinese 985 project
WOS记录号: WOS:000280870700014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60570
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: Peking Univ, Div Renal, Minist Hlth China, Hosp 1,Inst Nephrol,Key Lab Renal Dis,Dept Med, Beijing 100034, Peoples R China

Recommended Citation:
Lin, Wei,Chen, Min,Cui, Zhao,et al. The Immunopathological Spectrum of Crescentic Glomerulonephritis: A Survey of 106 Patients in a Single Chinese Center[J]. NEPHRON CLINICAL PRACTICE,2010,116(1):C65-C74.
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