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学科主题临床医学
The Immunopathological Spectrum of Crescentic Glomerulonephritis: A Survey of 106 Patients in a Single Chinese Center
Lin, Wei; Chen, Min; Cui, Zhao; Zhao, Ming-Hui
关键词Crescentic glomerulonephritis Antineutrophil cytoplasmic antibodies Anti-glomerular basement membrane Immunofluorescence
刊名NEPHRON CLINICAL PRACTICE
2010
DOI10.1159/000314665
116期:1页:C65-C74
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]BASEMENT-MEMBRANE DISEASE ; ANTI-GBM ANTIBODIES ; PATHOLOGICAL CHARACTERISTICS ; IMMUNE DEPOSITS ; ANCA ; VASCULITIS ; MYELOPEROXIDASE ; KIDNEY ; NEPHROPATHY
英文摘要

Background: Crescentic glomerulonephritis (CrGN) is a severe form of glomerular injury. We retrospectively analyzed data from Chinese patients with CrGN in our center to characterize the immunopathological spectrum of CrGN. Methods: A total of 106 consecutive patients with biopsy-proven CrGN were recruited. CrGN was classified into 3 types according to findings on immunofluorescence microscopy; type I was defined as a linear deposition of immunoglobulins along the glomerular basement membrane (GBM), type II as a glomerular deposition of immune-complex and type III as a pauci-immune deposition. Results: A total of 17/106 (16.0%) patients were classified as type I, 43/106 (40.6%) as type II and 46/106 (43.4%) as type III. Serum antineutrophil cytoplasmic antibodies (ANCA) could be detected in 1/17 (5.9%) patient with type I, 11/43 (25.6%) patients with type II and 29/46 (63.0%) patients with type III CrGN (p < 0.001). Serum anti-GBM antibodies could be detected in 14/17 (82.4%) patients with type I, 2/43 (4.7%) patients with type II and 3/46 (6.5%) patients with type III. In type II CrGN, ANCA-positive patients were older (p < 0.001), had more multi-system involvement (p < 0.001) and more fibrinoid necrosis in renal histopathology than ANCA-negative patients (p = 0.003). Conclusions: Pauci-immune CrGN might be the most common type of CrGN in Northern China. There was much heterogeneity within each type of CrGN. Copyright (C) 2010 S. Karger AG, Basel

语种英语
WOS记录号WOS:000280870700014
项目编号30725034 ; 30972733 ; 985-2-104-113
资助机构National Science Fund for Distinguished Young Scholars ; National Natural Science Fund ; Chinese 985 project
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60570
专题北京大学第一临床医学院_肾脏内科
作者单位Peking Univ, Div Renal, Minist Hlth China, Hosp 1,Inst Nephrol,Key Lab Renal Dis,Dept Med, Beijing 100034, Peoples R China
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GB/T 7714
Lin, Wei,Chen, Min,Cui, Zhao,et al. The Immunopathological Spectrum of Crescentic Glomerulonephritis: A Survey of 106 Patients in a Single Chinese Center[J]. NEPHRON CLINICAL PRACTICE,2010,116(1):C65-C74.
APA Lin, Wei,Chen, Min,Cui, Zhao,&Zhao, Ming-Hui.(2010).The Immunopathological Spectrum of Crescentic Glomerulonephritis: A Survey of 106 Patients in a Single Chinese Center.NEPHRON CLINICAL PRACTICE,116(1),C65-C74.
MLA Lin, Wei,et al."The Immunopathological Spectrum of Crescentic Glomerulonephritis: A Survey of 106 Patients in a Single Chinese Center".NEPHRON CLINICAL PRACTICE 116.1(2010):C65-C74.
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