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学科主题: 临床医学
题名:
Sulfur dioxide derivatives improve the vasorelaxation in the spontaneously hypertensive rat by enhancing the vasorelaxant response to nitric oxide
作者: Lu, Wei1; Sun, Yan1; Tang, Chaoshu2,3; Ochs, Todd4; Qi, Jianguang1; Du, Junbao1,3; Jin, Hongfang1
关键词: sulfur dioxide ; nitric oxide ; vasorelaxation ; spontaneously hypertensive rat
刊名: EXPERIMENTAL BIOLOGY AND MEDICINE
发表日期: 2012-07-01
DOI: 10.1258/ebm.2012.011304
卷: 237, 期:7, 页:867-872
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: BLOOD-PRESSURE ; SERUM SULFITE ; METABOLISM ; ORGANS ; MICE ; CYSTEINE ; SYSTEM ; SIGNAL
英文摘要:

The present study was designed to explore the role of sulfur dioxide (SO2) in the regulation of vasorelaxation in the spontaneously hypertensive rat (SHR). Twenty-two Wistar rats and 15 SHRs were divided randomly into the following groups: Wistar-Kyoto (WKY) control (n = 8), WKY+Na2SO3/NaHSO3 (n = 8), WKY+L-aspartic acid-beta-hydroxamate (HDX) (n = 6), SHR control (n = 8) and SHR+Na2SO3/NaHSO3 (n = 7). Their blood pressure in vivo was measured by tail plethysmography. The vasorelaxant response of the thoracic aorta to acetylcholine (Ach) and sodium nitroprusside (SNP) in all rats was tested, respectively, in the experiment. At the same time, the SO2 content of the WKY aorta after incubation with HDX and the vasorelaxant response to Ach after incubation with HDX were quantified. Nitric oxide (NO) production in the aorta of all rats was determined. We also measured the vasorelaxant responses of WKY aorta to different concentrations of SO2 after incubation with the NO inhibitor, N-G-nitro-L-arginine methyl ester (L-NAME). The blood pressure decreased significantly in SHRs treated with SO2 derivatives (P < 0.05). Reduction of endogenous SO2 in WKY vessels resulted in a decrease in the vasorelaxation induced by Ach. Vasorelaxation in response to both Ach and SNP increased in SHRs treated with SO2 derivatives compared with SHR controls, but decreased in WKY given HDX compared with WKY controls (P < 0.05). The NO level in arterial tissues increased in SHRs treated with SO2 derivatives (P < 0.05). However, the vasorelaxant response to SO2 derivatives in the presence of L-NAME decreased markedly compared with WKY controls. The results suggest that SO2 reduced blood pressure and increased vasorelaxation in SHR arteries via enhancing the vasorelaxant response to NO in isolated aortic rings and increasing the NO level of aortic tissues.

语种: 英语
所属项目编号: 2012BA103B03 ; 2011CB503904 ; 81121061 ; 81070111 ; 31130030 ; 7112130
项目资助者: Major Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000308678800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60571
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
3.Minist Educ, Key Lab Mol Cardiol, Beijing 100191, Peoples R China
4.Ann & Robert Lurie Childrens Hosp, Feinberg Sch Med, Chicago, IL 60611 USA

Recommended Citation:
Lu, Wei,Sun, Yan,Tang, Chaoshu,et al. Sulfur dioxide derivatives improve the vasorelaxation in the spontaneously hypertensive rat by enhancing the vasorelaxant response to nitric oxide[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2012,237(7):867-872.
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