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学科主题: 药学
题名:
Cationic Cobalt(III)-Catalyzed Aryl and Alkenyl CH Amidation: A Mild Protocol for the Modification of Purine Derivatives
作者: Liang, Yujie1; Liang, Yu-Feng1; Tang, Conghui1; Yuan, Yizhi1; Jiao, Ning1,2
关键词: amidation ; CH functionalization ; CN bond formation ; cobalt ; purine compounds
刊名: CHEMISTRY-A EUROPEAN JOURNAL
发表日期: 2015-11-09
DOI: 10.1002/chem.201503533
卷: 21, 期:46, 页:16395-16399
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: H BOND ACTIVATION ; N-TYPE REACTIONS ; 6-ARYLPURINE NUCLEOSIDES ; CYTOSTATIC ACTIVITY ; DIRECT ARYLATION ; CATALYZED CH ; ACYL AZIDES ; FUNCTIONALIZATION ; CLEAVAGE ; PHOTOLYSIS
英文摘要:

A cationic cobalt(III)-catalyzed direct CH amidation of unactivated (hetero)arenes and alkenes by using 1,4,2-dioxazol-5-ones as the amidating reagent has been developed. This transformation proceeds efficiently under external oxidant-free conditions with a broad substrate scope. Moreover, 6-arylpurine compounds, which often exhibit high potency in antimycobacterial, cytostatic, and anti-HCV activities, can be smoothly amidated, thus offering a mild protocol for their late stage functionalization.

语种: 英语
所属项目编号: 2015CB856600 ; 21325206 ; 21172006
项目资助者: National Basic Research Program of China (973 Program) ; National Science Foundation of China ; National Young Top-notch Talent Support Program
WOS记录号: WOS:000365132100016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60572
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

Recommended Citation:
Liang, Yujie,Liang, Yu-Feng,Tang, Conghui,et al. Cationic Cobalt(III)-Catalyzed Aryl and Alkenyl CH Amidation: A Mild Protocol for the Modification of Purine Derivatives[J]. CHEMISTRY-A EUROPEAN JOURNAL,2015,21(46):16395-16399.
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