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学科主题临床医学
Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2
Zhang, Yanlin; Guan, Li; Wang, Xifu; Wen, Tao; Xing, Junjie; Zhao, Jinyuan
关键词free radicals HO-1 NQO1 chlorophyllin Nrf2 PI3K/Akt
刊名FREE RADICAL RESEARCH
2008
DOI10.1080/10715760801993076
42期:4页:362-371
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]GENE-EXPRESSION ; HEME OXYGENASE ; PHOSPHATIDYLINOSITOL 3-KINASE/AKT ; AFLATOXIN B-1 ; RAINBOW-TROUT ; IN-VITRO ; ANTIOXIDANT ; STRESS ; INJURY ; CELLS
英文摘要

Green vegetables are thought to have a chemoprotective effect on the basis of epidemiologic evidence. This study investigated whether chlorophyllin (CHL) could induce antioxidant enzymes and confer protection against oxidative damage. The results showed that CHL could induce HO-1 and NQO1 expression in human umbilical vein endothelial cell (HUVEC) in a time-and dose-dependent manner and protect them against hydrogen peroxide caused oxidative damage. The induction of HO-1 and NQO1 by CHL was accompanied with the accumulation of transcription factor Nrf2 in nucleus and the activation of PI3K/Akt signalling pathway. Additionally, the specific inhibitor of PI3K/Akt could obviously decrease not only the induced expression of HO-1 and NQO1 but also the antioxidant effect of CHL. In conclusion, this study proved that CHL exerts antioxidant effect by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2. One thinks CHL may have promise to be prophylactic pharmaceuticals without adverse effects.

语种英语
WOS记录号WOS:000254869700009
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60574
专题北京大学第三临床医学院_职业病科
作者单位Peking Univ, Hosp 3, Res Ctr Occupat Med, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yanlin,Guan, Li,Wang, Xifu,et al. Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2[J]. FREE RADICAL RESEARCH,2008,42(4):362-371.
APA Zhang, Yanlin,Guan, Li,Wang, Xifu,Wen, Tao,Xing, Junjie,&Zhao, Jinyuan.(2008).Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2.FREE RADICAL RESEARCH,42(4),362-371.
MLA Zhang, Yanlin,et al."Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2".FREE RADICAL RESEARCH 42.4(2008):362-371.
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