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IR@PKUHSC  > 北京大学第三临床医学院  > 职业病科  > 期刊论文
学科主题: 临床医学
题名:
Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2
作者: Zhang, Yanlin; Guan, Li; Wang, Xifu; Wen, Tao; Xing, Junjie; Zhao, Jinyuan
关键词: free radicals ; HO-1 ; NQO1 ; chlorophyllin ; Nrf2 ; PI3K/Akt
刊名: FREE RADICAL RESEARCH
发表日期: 2008
DOI: 10.1080/10715760801993076
卷: 42, 期:4, 页:362-371
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: GENE-EXPRESSION ; HEME OXYGENASE ; PHOSPHATIDYLINOSITOL 3-KINASE/AKT ; AFLATOXIN B-1 ; RAINBOW-TROUT ; IN-VITRO ; ANTIOXIDANT ; STRESS ; INJURY ; CELLS
英文摘要:

Green vegetables are thought to have a chemoprotective effect on the basis of epidemiologic evidence. This study investigated whether chlorophyllin (CHL) could induce antioxidant enzymes and confer protection against oxidative damage. The results showed that CHL could induce HO-1 and NQO1 expression in human umbilical vein endothelial cell (HUVEC) in a time-and dose-dependent manner and protect them against hydrogen peroxide caused oxidative damage. The induction of HO-1 and NQO1 by CHL was accompanied with the accumulation of transcription factor Nrf2 in nucleus and the activation of PI3K/Akt signalling pathway. Additionally, the specific inhibitor of PI3K/Akt could obviously decrease not only the induced expression of HO-1 and NQO1 but also the antioxidant effect of CHL. In conclusion, this study proved that CHL exerts antioxidant effect by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2. One thinks CHL may have promise to be prophylactic pharmaceuticals without adverse effects.

语种: 英语
WOS记录号: WOS:000254869700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60574
Appears in Collections:北京大学第三临床医学院_职业病科_期刊论文

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作者单位: Peking Univ, Hosp 3, Res Ctr Occupat Med, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, Yanlin,Guan, Li,Wang, Xifu,et al. Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2[J]. FREE RADICAL RESEARCH,2008,42(4):362-371.
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