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学科主题临床医学
Tunicamycin suppresses cisplatin-induced HepG2 cell apoptosis via enhancing p53 protein nuclear export
Zhang, Li-Juan1; Li, Zai-Quan1,2; Yang, Ye-Peng2; Li, Xiao-Wen1; Ji, Jia-Fu3
关键词Endoplasmic reticulum stress Cisplatin resistance Apoptosis Tumor suppressor p53 HepG2 cell Tunicamycin
刊名MOLECULAR AND CELLULAR BIOCHEMISTRY
2009-07-01
DOI10.1007/s11010-009-0055-z
327期:1-2页:171-182
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]ENDOPLASMIC-RETICULUM STRESS ; GLYCOGEN-SYNTHASE KINASE-3-BETA ; MEDIATED APOPTOSIS ; CANCER-CELLS ; HYPOXIA ; GRP78 ; INDUCTION ; CARCINOMA ; SURVIVAL ; DRUGS
英文摘要

Cisplatin is a widely used anticancer drug; however, resistance to cisplatin-based chemotherapy is a major cause of treatment failure in patients with tumors. The present study was undertaken to investigate whether and how endoplasmic reticulum (ER) stress initiated by tunicamycin, which inhibits glycosylation, influences cisplatin-induced apoptosis in HepG2 cells. Pretreatment of HepG2 cells with ER stress inducers brought about a decrease in both cisplatin-induced cytotoxic effects and apoptosis. In order to further explore the mechanism underlying tumor resistance to cisplatin, we observed that increased nuclear export of endogenous p53 protein by pharmacological inducers of ER stress, such as tunicamycin, was associated with the suppression of cisplatin-induced apoptosis. These results suggested that tumor suppressor p53 protein may play a key role in cisplatin-induced HepG2 cells apoptosis. It is therefore suggested that the treatment of some tumor patients with cisplatin be combined with the down-regulation of endogenous ER stress to improve the clinical results of cisplatin-based chemotherapy.

语种英语
WOS记录号WOS:000266385400021
项目编号30470846
资助机构National Natural Sciences Foundation of the People&prime ; s Republic of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60575
专题北京大学临床肿瘤学院
北京大学医学部管理机构_人事处
北京大学医学部管理机构_医学部
北京大学公共卫生学院_公共卫生学院
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
作者单位1.Peking Univ, Dept Biochem & Mol Biol, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Dept Radiant Med, Hlth Sci Ctr, Beijing 100083, Peoples R China
3.Peking Univ, Beijing Inst Canc Res, Sch Oncol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Li-Juan,Li, Zai-Quan,Yang, Ye-Peng,et al. Tunicamycin suppresses cisplatin-induced HepG2 cell apoptosis via enhancing p53 protein nuclear export[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2009,327(1-2):171-182.
APA Zhang, Li-Juan,Li, Zai-Quan,Yang, Ye-Peng,Li, Xiao-Wen,&Ji, Jia-Fu.(2009).Tunicamycin suppresses cisplatin-induced HepG2 cell apoptosis via enhancing p53 protein nuclear export.MOLECULAR AND CELLULAR BIOCHEMISTRY,327(1-2),171-182.
MLA Zhang, Li-Juan,et al."Tunicamycin suppresses cisplatin-induced HepG2 cell apoptosis via enhancing p53 protein nuclear export".MOLECULAR AND CELLULAR BIOCHEMISTRY 327.1-2(2009):171-182.
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