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学科主题: 临床医学
题名:
Tunicamycin suppresses cisplatin-induced HepG2 cell apoptosis via enhancing p53 protein nuclear export
作者: Zhang, Li-Juan1; Li, Zai-Quan1,2; Yang, Ye-Peng2; Li, Xiao-Wen1; Ji, Jia-Fu3
关键词: Endoplasmic reticulum stress ; Cisplatin resistance ; Apoptosis ; Tumor suppressor p53 ; HepG2 cell ; Tunicamycin
刊名: MOLECULAR AND CELLULAR BIOCHEMISTRY
发表日期: 2009-07-01
DOI: 10.1007/s11010-009-0055-z
卷: 327, 期:1-2, 页:171-182
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: ENDOPLASMIC-RETICULUM STRESS ; GLYCOGEN-SYNTHASE KINASE-3-BETA ; MEDIATED APOPTOSIS ; CANCER-CELLS ; HYPOXIA ; GRP78 ; INDUCTION ; CARCINOMA ; SURVIVAL ; DRUGS
英文摘要:

Cisplatin is a widely used anticancer drug; however, resistance to cisplatin-based chemotherapy is a major cause of treatment failure in patients with tumors. The present study was undertaken to investigate whether and how endoplasmic reticulum (ER) stress initiated by tunicamycin, which inhibits glycosylation, influences cisplatin-induced apoptosis in HepG2 cells. Pretreatment of HepG2 cells with ER stress inducers brought about a decrease in both cisplatin-induced cytotoxic effects and apoptosis. In order to further explore the mechanism underlying tumor resistance to cisplatin, we observed that increased nuclear export of endogenous p53 protein by pharmacological inducers of ER stress, such as tunicamycin, was associated with the suppression of cisplatin-induced apoptosis. These results suggested that tumor suppressor p53 protein may play a key role in cisplatin-induced HepG2 cells apoptosis. It is therefore suggested that the treatment of some tumor patients with cisplatin be combined with the down-regulation of endogenous ER stress to improve the clinical results of cisplatin-based chemotherapy.

语种: 英语
所属项目编号: 30470846
项目资助者: National Natural Sciences Foundation of the People&prime ; s Republic of China
WOS记录号: WOS:000266385400021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60575
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Dept Biochem & Mol Biol, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Dept Radiant Med, Hlth Sci Ctr, Beijing 100083, Peoples R China
3.Peking Univ, Beijing Inst Canc Res, Sch Oncol, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Li-Juan,Li, Zai-Quan,Yang, Ye-Peng,et al. Tunicamycin suppresses cisplatin-induced HepG2 cell apoptosis via enhancing p53 protein nuclear export[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2009,327(1-2):171-182.
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