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Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells
Zhao, Chong1; Yin, Shutao1; Dong, Yinhui1; Guo, Xiao1; Fan, Lihong2; Ye, Min3; Hu, Hongbo1
关键词ursolic acid MCF-7 ER stress EIF2AK3 autophagy MCL1 cytoprotection apoptosis
刊名AUTOPHAGY
2013-02-01
DOI10.4161/auto.22805
9期:2页:196-207
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]ENDOPLASMIC-RETICULUM STRESS ; MULTIPLE-MYELOMA CELLS ; IN-VITRO ; INHIBITION ; PHOSPHORYLATION ; PATHWAY ; KINASE ; DEATH ; CHEMOPREVENTION ; SURVIVAL
英文摘要

Ursolic acid (UA) is a pentacyclic triterpenoid with promising cancer chemopreventive properties. A better understanding of the mechanisms underlying anticancer activity of UA is needed for further development as a clinically useful chemopreventive agent. Here, we found that both endoplasmic reticulum (ER) stress and autophagy were induced by UA in MCF-7 human breast cancer cells. Surprisingly, ER stress was identified as an effect rather than a cause of UA-induced autophagy. Autophagy-dependent ER stress protected the cells from UA-induced apoptosis through EIF2AK3-mediated upregulation of MCL1. Activation of MAPK1/3 but not inhibition of MTOR pathway contributed to UA-induced cytoprotective autophagy in MCF-7 cells. Our findings uncovered a novel cellular mechanism involved in the anticancer activity of UA, and also provided a useful model to study biological significance and mechanisms of autophagy-mediated ER stress.

语种英语
WOS记录号WOS:000314218700007
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60580
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.China Agr Univ, Coll Food Sci & Nutr Engn, Dept Nutr & Hlth, Beijing 100094, Peoples R China
2.China Agr Univ, Coll Vet Med, Beijing 100094, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
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GB/T 7714
Zhao, Chong,Yin, Shutao,Dong, Yinhui,et al. Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells[J]. AUTOPHAGY,2013,9(2):196-207.
APA Zhao, Chong.,Yin, Shutao.,Dong, Yinhui.,Guo, Xiao.,Fan, Lihong.,...&Hu, Hongbo.(2013).Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells.AUTOPHAGY,9(2),196-207.
MLA Zhao, Chong,et al."Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells".AUTOPHAGY 9.2(2013):196-207.
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