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学科主题: 药学
题名:
Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells
作者: Zhao, Chong1; Yin, Shutao1; Dong, Yinhui1; Guo, Xiao1; Fan, Lihong2; Ye, Min3; Hu, Hongbo1
关键词: ursolic acid ; MCF-7 ; ER stress ; EIF2AK3 ; autophagy ; MCL1 ; cytoprotection ; apoptosis
刊名: AUTOPHAGY
发表日期: 2013-02-01
DOI: 10.4161/auto.22805
卷: 9, 期:2, 页:196-207
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: ENDOPLASMIC-RETICULUM STRESS ; MULTIPLE-MYELOMA CELLS ; IN-VITRO ; INHIBITION ; PHOSPHORYLATION ; PATHWAY ; KINASE ; DEATH ; CHEMOPREVENTION ; SURVIVAL
英文摘要:

Ursolic acid (UA) is a pentacyclic triterpenoid with promising cancer chemopreventive properties. A better understanding of the mechanisms underlying anticancer activity of UA is needed for further development as a clinically useful chemopreventive agent. Here, we found that both endoplasmic reticulum (ER) stress and autophagy were induced by UA in MCF-7 human breast cancer cells. Surprisingly, ER stress was identified as an effect rather than a cause of UA-induced autophagy. Autophagy-dependent ER stress protected the cells from UA-induced apoptosis through EIF2AK3-mediated upregulation of MCL1. Activation of MAPK1/3 but not inhibition of MTOR pathway contributed to UA-induced cytoprotective autophagy in MCF-7 cells. Our findings uncovered a novel cellular mechanism involved in the anticancer activity of UA, and also provided a useful model to study biological significance and mechanisms of autophagy-mediated ER stress.

语种: 英语
所属项目编号: 2012BAD33B09 ; 31071533 ; 30972172 ; 2009-2-11
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China (NSFC) ; Chinese Universities Scientific Fund
WOS记录号: WOS:000314218700007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60580
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.China Agr Univ, Coll Food Sci & Nutr Engn, Dept Nutr & Hlth, Beijing 100094, Peoples R China
2.China Agr Univ, Coll Vet Med, Beijing 100094, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China

Recommended Citation:
Zhao, Chong,Yin, Shutao,Dong, Yinhui,et al. Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells[J]. AUTOPHAGY,2013,9(2):196-207.
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